Abstract
OBJECTIVE: To investigate the pathophysiological role of pro- and anti-inflammatory cytokines in primary multiple sclerosis-related fatigue.
METHODS: Fatigued and non-fatigued patients with multiple sclerosis (MS) were recruited and their cytokine profiles compared. Patients with secondary fatigue were excluded. Fatigue was assessed with the self-reported Checklist Individual Strength (CIS20r), subscale fatigue. A CIS20r fatigue cut-off score of 35 was applied to differentiate between non-fatigued (CIS20r fatigue ≤34) and fatigued (CIS20r fatigue ≥35) patients with MS. Blood was collected to determine the serum concentrations of pro-inflammatory cytokines (IL-1β, IL-2, IL-6, IL-8, IL-12p70, IL-17, TNFα, and IFN-γ) and anti-inflammatory cytokines (IL-4, IL-5, IL-10, and IL-13). We controlled for the confounding effect of age, gender, duration of MS, disease severity, type of MS, and use of immunomodulatory drugs.
RESULTS: Similar cytokine levels were observed between MS patients with (n = 21) and without fatigue (n = 14). Adjusted multiple regression analyses showed a single significant positive relationship, that of IL-6 with CIS20r fatigue score. The explained variance of the IL-6 model was 21.1%, once adjusted for the confounding effect of age.
CONCLUSION: The pro-inflammatory cytokine interleukin-6 (IL-6) may play a role in the pathophysiology of primary fatigue in patients with MS.
TRIAL REGISTRATIONS: ISRCTN69520623, ISRCTN58583714, and ISRCTN82353628.
| Original language | English |
|---|---|
| Article number | 758314 |
| Number of pages | 7 |
| Journal | Disease markers |
| Volume | 2015 |
| DOIs | |
| Publication status | Published - 2015 |
Keywords
- Adolescent
- Adult
- Aged
- Fatigue
- Female
- Humans
- Interferon-gamma
- Interleukins
- Male
- Middle Aged
- Multiple Sclerosis
- Tumor Necrosis Factor-alpha