Fatal Carbapenem Resistance Development in Pseudomonas Aeruginosa Under Meropenem Monotherapy, Caused by Mutations in the Oprd Outer Membrane Porin

Ad C Fluit; Rob J Rentenaar; Miquel B Ekkelenkamp; Tim T Severs; Annelies M C Mavinkurve-Groothuis; Malbert R C Rogers; Marrie C A Bruin; Tom F W Wolfs

doi:10.1097/INF.0000000000002244

Fatal Carbapenem Resistance Development in Pseudomonas Aeruginosa Under Meropenem Monotherapy, Caused by Mutations in the Oprd Outer Membrane Porin

Ad C Fluit
, Rob J Rentenaar
, Miquel B Ekkelenkamp
, Tim T Severs
, Annelies M C Mavinkurve-Groothuis
, Malbert R C Rogers
, Marrie C A Bruin
, Tom F W Wolfs

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

A 13-year old neutropenic boy succumbed to bacteremia and sepsis with a Pseudomonas aeruginosa strain that rapidly developed resistance to carbapenems during meropenem monotherapy. Whole genome sequencing of the susceptible and resistant blood culture isolates revealed the meropenem-resistant phenotype to be caused by truncation of the oprD gene, which added to a pre-existing inactivated mexR gene.

Original language	English
Pages (from-to)	398-399
Number of pages	2
Journal	The Pediatric infectious disease journal
Volume	38
Issue number	4
Early online date	13 Nov 2018
DOIs	https://doi.org/10.1097/INF.0000000000002244
Publication status	Published - Apr 2019

Keywords

Pseudomonas aeruginosa
febrile neutropenia
imipenem resistant
meropenem resistant
mexR
oprD
sepsis

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10.1097/INF.0000000000002244

fluitFinal published version, 64.6 KBLicence: Taverne

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Fluit, A. C., Rentenaar, R. J., Ekkelenkamp, M. B., Severs, T. T., Mavinkurve-Groothuis, A. M. C., Rogers, M. R. C., Bruin, M. C. A., & Wolfs, T. F. W. (2019). Fatal Carbapenem Resistance Development in Pseudomonas Aeruginosa Under Meropenem Monotherapy, Caused by Mutations in the Oprd Outer Membrane Porin. The Pediatric infectious disease journal, 38(4), 398-399. https://doi.org/10.1097/INF.0000000000002244

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title = "Fatal Carbapenem Resistance Development in Pseudomonas Aeruginosa Under Meropenem Monotherapy, Caused by Mutations in the Oprd Outer Membrane Porin",

abstract = "A 13-year old neutropenic boy succumbed to bacteremia and sepsis with a Pseudomonas aeruginosa strain that rapidly developed resistance to carbapenems during meropenem monotherapy. Whole genome sequencing of the susceptible and resistant blood culture isolates revealed the meropenem-resistant phenotype to be caused by truncation of the oprD gene, which added to a pre-existing inactivated mexR gene.",

keywords = "Pseudomonas aeruginosa, febrile neutropenia, imipenem resistant, meropenem resistant, mexR, oprD, sepsis",

author = "Fluit, \{Ad C\} and Rentenaar, \{Rob J\} and Ekkelenkamp, \{Miquel B\} and Severs, \{Tim T\} and Mavinkurve-Groothuis, \{Annelies M C\} and Rogers, \{Malbert R C\} and Bruin, \{Marrie C A\} and Wolfs, \{Tom F W\}",

year = "2019",

month = apr,

doi = "10.1097/INF.0000000000002244",

language = "English",

volume = "38",

pages = "398--399",

journal = "The Pediatric infectious disease journal",

issn = "0891-3668",

publisher = "Lippincott Williams \& Wilkins",

number = "4",

}

Fluit, AC, Rentenaar, RJ, Ekkelenkamp, MB, Severs, TT, Mavinkurve-Groothuis, AMC, Rogers, MRC, Bruin, MCA & Wolfs, TFW 2019, 'Fatal Carbapenem Resistance Development in Pseudomonas Aeruginosa Under Meropenem Monotherapy, Caused by Mutations in the Oprd Outer Membrane Porin', The Pediatric infectious disease journal, vol. 38, no. 4, pp. 398-399. https://doi.org/10.1097/INF.0000000000002244

Fatal Carbapenem Resistance Development in Pseudomonas Aeruginosa Under Meropenem Monotherapy, Caused by Mutations in the Oprd Outer Membrane Porin. / Fluit, Ad C; Rentenaar, Rob J; Ekkelenkamp, Miquel B et al.
In: The Pediatric infectious disease journal, Vol. 38, No. 4, 04.2019, p. 398-399.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Fatal Carbapenem Resistance Development in Pseudomonas Aeruginosa Under Meropenem Monotherapy, Caused by Mutations in the Oprd Outer Membrane Porin

AU - Fluit, Ad C

AU - Rentenaar, Rob J

AU - Ekkelenkamp, Miquel B

AU - Severs, Tim T

AU - Mavinkurve-Groothuis, Annelies M C

AU - Rogers, Malbert R C

AU - Bruin, Marrie C A

AU - Wolfs, Tom F W

PY - 2019/4

Y1 - 2019/4

N2 - A 13-year old neutropenic boy succumbed to bacteremia and sepsis with a Pseudomonas aeruginosa strain that rapidly developed resistance to carbapenems during meropenem monotherapy. Whole genome sequencing of the susceptible and resistant blood culture isolates revealed the meropenem-resistant phenotype to be caused by truncation of the oprD gene, which added to a pre-existing inactivated mexR gene.

AB - A 13-year old neutropenic boy succumbed to bacteremia and sepsis with a Pseudomonas aeruginosa strain that rapidly developed resistance to carbapenems during meropenem monotherapy. Whole genome sequencing of the susceptible and resistant blood culture isolates revealed the meropenem-resistant phenotype to be caused by truncation of the oprD gene, which added to a pre-existing inactivated mexR gene.

KW - Pseudomonas aeruginosa

KW - febrile neutropenia

KW - imipenem resistant

KW - meropenem resistant

KW - mexR

KW - oprD

KW - sepsis

UR - https://www.scopus.com/pages/publications/85063294184

U2 - 10.1097/INF.0000000000002244

DO - 10.1097/INF.0000000000002244

M3 - Article

C2 - 30431524

SN - 0891-3668

VL - 38

SP - 398

EP - 399

JO - The Pediatric infectious disease journal

JF - The Pediatric infectious disease journal

IS - 4

ER -

Fatal Carbapenem Resistance Development in Pseudomonas Aeruginosa Under Meropenem Monotherapy, Caused by Mutations in the Oprd Outer Membrane Porin

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Keywords

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