Fatal Carbapenem Resistance Development in Pseudomonas Aeruginosa Under Meropenem Monotherapy, Caused by Mutations in the Oprd Outer Membrane Porin

Ad C Fluit, Rob J Rentenaar, Miquel B Ekkelenkamp, Tim T Severs, Annelies M C Mavinkurve-Groothuis, Malbert R C Rogers, Marrie C A Bruin, Tom F W Wolfs

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

A 13-year old neutropenic boy succumbed to bacteremia and sepsis with a Pseudomonas aeruginosa strain that rapidly developed resistance to carbapenems during meropenem monotherapy. Whole genome sequencing of the susceptible and resistant blood culture isolates revealed the meropenem-resistant phenotype to be caused by truncation of the oprD gene, which added to a pre-existing inactivated mexR gene.

Original languageEnglish
Pages (from-to)398-399
Number of pages2
JournalThe Pediatric infectious disease journal
Volume38
Issue number4
Early online date13 Nov 2018
DOIs
Publication statusPublished - Apr 2019

Keywords

  • Pseudomonas aeruginosa
  • febrile neutropenia
  • imipenem resistant
  • meropenem resistant
  • mexR
  • oprD
  • sepsis

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