Abstract
A 13-year old neutropenic boy succumbed to bacteremia and sepsis with a Pseudomonas aeruginosa strain that rapidly developed resistance to carbapenems during meropenem monotherapy. Whole genome sequencing of the susceptible and resistant blood culture isolates revealed the meropenem-resistant phenotype to be caused by truncation of the oprD gene, which added to a pre-existing inactivated mexR gene.
Original language | English |
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Pages (from-to) | 398-399 |
Number of pages | 2 |
Journal | The Pediatric infectious disease journal |
Volume | 38 |
Issue number | 4 |
Early online date | 13 Nov 2018 |
DOIs | |
Publication status | Published - Apr 2019 |
Keywords
- Pseudomonas aeruginosa
- febrile neutropenia
- imipenem resistant
- meropenem resistant
- mexR
- oprD
- sepsis