TY - JOUR
T1 - Fast technetium-99m liver SPECT for evaluation of the pretreatment procedure for radioembolization dosimetry
AU - van der Velden, Sandra
AU - Dietze, Martijn M A
AU - Viergever, Max A
AU - de Jong, Hugo W A M
N1 - Funding Information:
This work is part of the research program Innovational Research Incentives with project number 12977 which is (partly) financed by the Netherlands Organisation for Scientific Research (NWO).
Publisher Copyright:
© 2018 The Authors. Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2019/1
Y1 - 2019/1
N2 - Purpose: The efficiency of radioembolization procedures could be greatly enhanced if results of the
99m Tc-MAA pretreatment procedure were immediately available in the interventional suite, enabling 1-day procedures as a result of direct estimation of the hepatic radiation dose and lung shunt fraction. This would, however, require a relatively fast, but still quantitative, SPECT procedure, which might be achieved with acquisition protocols using nonuniform durations of the projection images. Methods: SPECT liver images of the 150-MBq
99m Tc-MAA pretreatment procedure were simulated for eight different lesion locations and two different lesion sizes using the digital XCAT phantom for both single- and dual-head scanning geometries with respective total acquisition times of 1, 2, 5, 10, and 30 min. Three nonuniform projection-time acquisition protocols (“half-circle SPECT (HCS),” “nonuniform SPECT (NUS) I,” and “NUS II”) for fast quantitative SPECT of the liver were designed and compared with the standard uniform projection-time protocol. Images were evaluated in terms of contrast-to-noise ratio (CNR), activity recovery coefficient (ARC), tumor/non-tumor (T/N) activity concentration ratio, and lung shunt fraction (LSF) estimation. In addition, image quality was verified with a physical phantom experiment, reconstructed with both clinical and Monte Carlo-based reconstruction software. Results: Simulations showed no substantial change in image quality and dosimetry by usage of a nonuniform projection-time acquisition protocol. Upon shortening acquisition times, CNR dropped, but ARC, T/N ratio, and LSF estimates were stable across all simulated acquisition times. Results of the physical phantom were in agreement with those of the simulations. Conclusion: Both uniform and nonuniform projection-time acquisition liver SPECT protocols yield accurate dosimetric metrics for radioembolization treatment planning in the interventional suite within 10 min, without compromising image quality. Consequently, fast quantitative SPECT of the liver in the interventional suite is feasible.
AB - Purpose: The efficiency of radioembolization procedures could be greatly enhanced if results of the
99m Tc-MAA pretreatment procedure were immediately available in the interventional suite, enabling 1-day procedures as a result of direct estimation of the hepatic radiation dose and lung shunt fraction. This would, however, require a relatively fast, but still quantitative, SPECT procedure, which might be achieved with acquisition protocols using nonuniform durations of the projection images. Methods: SPECT liver images of the 150-MBq
99m Tc-MAA pretreatment procedure were simulated for eight different lesion locations and two different lesion sizes using the digital XCAT phantom for both single- and dual-head scanning geometries with respective total acquisition times of 1, 2, 5, 10, and 30 min. Three nonuniform projection-time acquisition protocols (“half-circle SPECT (HCS),” “nonuniform SPECT (NUS) I,” and “NUS II”) for fast quantitative SPECT of the liver were designed and compared with the standard uniform projection-time protocol. Images were evaluated in terms of contrast-to-noise ratio (CNR), activity recovery coefficient (ARC), tumor/non-tumor (T/N) activity concentration ratio, and lung shunt fraction (LSF) estimation. In addition, image quality was verified with a physical phantom experiment, reconstructed with both clinical and Monte Carlo-based reconstruction software. Results: Simulations showed no substantial change in image quality and dosimetry by usage of a nonuniform projection-time acquisition protocol. Upon shortening acquisition times, CNR dropped, but ARC, T/N ratio, and LSF estimates were stable across all simulated acquisition times. Results of the physical phantom were in agreement with those of the simulations. Conclusion: Both uniform and nonuniform projection-time acquisition liver SPECT protocols yield accurate dosimetric metrics for radioembolization treatment planning in the interventional suite within 10 min, without compromising image quality. Consequently, fast quantitative SPECT of the liver in the interventional suite is feasible.
KW - acquisition protocol
KW - interventional imaging
KW - nuclear imaging
KW - radioembolization
KW - SPECT
KW - Technetium Tc 99m Aggregated Albumin
KW - Signal-To-Noise Ratio
KW - Tomography, Emission-Computed, Single-Photon
KW - Embolization, Therapeutic
KW - Time Factors
KW - Radiometry
KW - Phantoms, Imaging
KW - Liver/diagnostic imaging
UR - http://www.scopus.com/inward/record.url?scp=85056484701&partnerID=8YFLogxK
U2 - 10.1002/mp.13253
DO - 10.1002/mp.13253
M3 - Article
C2 - 30347130
SN - 0094-2405
VL - 46
SP - 345
EP - 355
JO - Medical Physics
JF - Medical Physics
IS - 1
ER -