Fast and accurate deformable contour propagation for intra-fraction adaptive magnetic resonance-guided prostate radiotherapy

Thomas Willigenburg; Cornel Zachiu; Jan J W Lagendijk; Jochem R N van der Voort van Zyp; Hans C J de Boer; Bas W Raaymakers

doi:10.1016/j.phro.2022.02.008

Fast and accurate deformable contour propagation for intra-fraction adaptive magnetic resonance-guided prostate radiotherapy

Thomas Willigenburg, Cornel Zachiu, Jan J W Lagendijk, Jochem R N van der Voort van Zyp, Hans C J de Boer, Bas W Raaymakers

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Abstract

To facilitate full intra-fraction adaptive MR-guided radiotherapy, accurate contour propagation is needed. We aimed to assess the clinical usability of intra-fraction propagated contours by a deformable image registration algorithm in ten prostate cancer patients. Two observers judged the contours on need for manual adaptation and feasibility of adapting contours within 3 min. CTV and bladder contours needed none or only minor editing in most cases (≥ 97%), whereas rectum contours needed more extensive editing in 12-23%. Nevertheless, adaptation times were < 3 min for ≥ 93% of the cases. This paves the way for exploring adaptive workflows using intra-fraction deformable contour propagation.

Original language	English
Pages (from-to)	62-65
Number of pages	4
Journal	Physics and Imaging in Radiation Oncology
Volume	21
DOIs	https://doi.org/10.1016/j.phro.2022.02.008
Publication status	Published - Jan 2022

Keywords

Intra-fraction adaptation
MR-guided linear accelerator
MRI-guided radiotherapy
Prostate cancer
Radiotherapy workflow

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10.1016/j.phro.2022.02.008Licence: CC BY

1-s2.0-S2405631622000148-mainFinal published version, 1.54 MBLicence: CC BY

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title = "Fast and accurate deformable contour propagation for intra-fraction adaptive magnetic resonance-guided prostate radiotherapy",

abstract = "To facilitate full intra-fraction adaptive MR-guided radiotherapy, accurate contour propagation is needed. We aimed to assess the clinical usability of intra-fraction propagated contours by a deformable image registration algorithm in ten prostate cancer patients. Two observers judged the contours on need for manual adaptation and feasibility of adapting contours within 3 min. CTV and bladder contours needed none or only minor editing in most cases (≥ 97%), whereas rectum contours needed more extensive editing in 12-23%. Nevertheless, adaptation times were < 3 min for ≥ 93% of the cases. This paves the way for exploring adaptive workflows using intra-fraction deformable contour propagation.",

keywords = "Intra-fraction adaptation, MR-guided linear accelerator, MRI-guided radiotherapy, Prostate cancer, Radiotherapy workflow",

author = "Thomas Willigenburg and Cornel Zachiu and Lagendijk, {Jan J W} and {van der Voort van Zyp}, {Jochem R N} and {de Boer}, {Hans C J} and Raaymakers, {Bas W}",

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AU - Willigenburg, Thomas

AU - Zachiu, Cornel

AU - Lagendijk, Jan J W

AU - van der Voort van Zyp, Jochem R N

AU - de Boer, Hans C J

AU - Raaymakers, Bas W

PY - 2022/1

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N2 - To facilitate full intra-fraction adaptive MR-guided radiotherapy, accurate contour propagation is needed. We aimed to assess the clinical usability of intra-fraction propagated contours by a deformable image registration algorithm in ten prostate cancer patients. Two observers judged the contours on need for manual adaptation and feasibility of adapting contours within 3 min. CTV and bladder contours needed none or only minor editing in most cases (≥ 97%), whereas rectum contours needed more extensive editing in 12-23%. Nevertheless, adaptation times were < 3 min for ≥ 93% of the cases. This paves the way for exploring adaptive workflows using intra-fraction deformable contour propagation.

AB - To facilitate full intra-fraction adaptive MR-guided radiotherapy, accurate contour propagation is needed. We aimed to assess the clinical usability of intra-fraction propagated contours by a deformable image registration algorithm in ten prostate cancer patients. Two observers judged the contours on need for manual adaptation and feasibility of adapting contours within 3 min. CTV and bladder contours needed none or only minor editing in most cases (≥ 97%), whereas rectum contours needed more extensive editing in 12-23%. Nevertheless, adaptation times were < 3 min for ≥ 93% of the cases. This paves the way for exploring adaptive workflows using intra-fraction deformable contour propagation.

KW - Intra-fraction adaptation

KW - MR-guided linear accelerator

KW - MRI-guided radiotherapy

KW - Prostate cancer

KW - Radiotherapy workflow

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EP - 65

JO - Physics and Imaging in Radiation Oncology

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Fast and accurate deformable contour propagation for intra-fraction adaptive magnetic resonance-guided prostate radiotherapy

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Keywords

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