Familial sudden death is an important risk factor for primary ventricular fibrillation: a case-control study in acute myocardial infarction patients

Lukas R C Dekker; Connie R Bezzina; José P S Henriques; Michael W Tanck; Karel T Koch; Marco W Alings; Alfred E R Arnold; Menko-Jan de Boer; Anton P M Gorgels; H Rolf Michels; Agnes Verkerk; Freek W A Verheugt; Felix Zijlstra; Arthur A M Wilde

doi:10.1161/CIRCULATIONAHA.105.606145

Familial sudden death is an important risk factor for primary ventricular fibrillation: a case-control study in acute myocardial infarction patients

Lukas R C Dekker, Connie R Bezzina, José P S Henriques, Michael W Tanck, Karel T Koch, Marco W Alings, Alfred E R Arnold, Menko-Jan de Boer, Anton P M Gorgels, H Rolf Michels, Agnes Verkerk, Freek W A Verheugt, Felix Zijlstra, Arthur A M Wilde

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Primary ventricular fibrillation (VF) accounts for the majority of deaths during the acute phase of myocardial infarction. Identification of patients at risk for primary VF remains very poor.

METHODS AND RESULTS: We performed a case-control study in patients with a first ST-elevation myocardial infarction (STEMI) to identify independent risk factors for primary VF. A total of 330 primary VF survivors (cases) and 372 controls were included; patients with earlier infarcts or signs of structural heart disease were excluded. Baseline characteristics, including age, gender, drug use, and ECG parameters registered well before the index infarction, as well as medical history, were not different. Infarct size and location, culprit coronary artery, and presence of multivessel disease were similar between groups. Analysis of ECGs performed at hospital admission for the index STEMI revealed that cumulative ST deviation was significantly higher among cases (OR per 10-mm ST deviation 1.59, 95% CI 1.25 to 2.02). Analysis of medical histories among parents and siblings showed that the prevalence of cardiovascular disease was similar between cases and controls (73.1% and 73.0%, respectively); however, familial sudden death occurred significantly more frequently among cases than controls (43.1% and 25.1%, respectively; OR 2.72, 95% CI 1.84 to 4.03).

CONCLUSIONS: In a population of STEMI patients, the risk of primary VF is determined by cumulative ST deviation and family history of sudden death.

Original language	English
Pages (from-to)	1140-5
Number of pages	6
Journal	Circulation
Volume	114
Issue number	11
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.105.606145
Publication status	Published - 12 Sept 2006
Externally published	Yes

Keywords

Adult
Aged
Arrhythmias, Cardiac/complications
Case-Control Studies
Death, Sudden, Cardiac/etiology
Electrocardiography
Female
Humans
Male
Middle Aged
Myocardial Infarction/complications
Netherlands
Phenotype
Risk Assessment
Risk Factors
Survival Rate
Ventricular Fibrillation/complications

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10.1161/CIRCULATIONAHA.105.606145

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Dekker, L. R. C., Bezzina, C. R., Henriques, J. P. S., Tanck, M. W., Koch, K. T., Alings, M. W., Arnold, A. E. R., de Boer, M.-J., Gorgels, A. P. M., Michels, H. R., Verkerk, A., Verheugt, F. W. A., Zijlstra, F., & Wilde, A. A. M. (2006). Familial sudden death is an important risk factor for primary ventricular fibrillation: a case-control study in acute myocardial infarction patients. Circulation, 114(11), 1140-5. https://doi.org/10.1161/CIRCULATIONAHA.105.606145

@article{20a1bfe07f7647a39dfc629e81d991ff,

title = "Familial sudden death is an important risk factor for primary ventricular fibrillation: a case-control study in acute myocardial infarction patients",

abstract = "BACKGROUND: Primary ventricular fibrillation (VF) accounts for the majority of deaths during the acute phase of myocardial infarction. Identification of patients at risk for primary VF remains very poor.METHODS AND RESULTS: We performed a case-control study in patients with a first ST-elevation myocardial infarction (STEMI) to identify independent risk factors for primary VF. A total of 330 primary VF survivors (cases) and 372 controls were included; patients with earlier infarcts or signs of structural heart disease were excluded. Baseline characteristics, including age, gender, drug use, and ECG parameters registered well before the index infarction, as well as medical history, were not different. Infarct size and location, culprit coronary artery, and presence of multivessel disease were similar between groups. Analysis of ECGs performed at hospital admission for the index STEMI revealed that cumulative ST deviation was significantly higher among cases (OR per 10-mm ST deviation 1.59, 95% CI 1.25 to 2.02). Analysis of medical histories among parents and siblings showed that the prevalence of cardiovascular disease was similar between cases and controls (73.1% and 73.0%, respectively); however, familial sudden death occurred significantly more frequently among cases than controls (43.1% and 25.1%, respectively; OR 2.72, 95% CI 1.84 to 4.03).CONCLUSIONS: In a population of STEMI patients, the risk of primary VF is determined by cumulative ST deviation and family history of sudden death.",

keywords = "Adult, Aged, Arrhythmias, Cardiac/complications, Case-Control Studies, Death, Sudden, Cardiac/etiology, Electrocardiography, Female, Humans, Male, Middle Aged, Myocardial Infarction/complications, Netherlands, Phenotype, Risk Assessment, Risk Factors, Survival Rate, Ventricular Fibrillation/complications",

author = "Dekker, {Lukas R C} and Bezzina, {Connie R} and Henriques, {Jos{\'e} P S} and Tanck, {Michael W} and Koch, {Karel T} and Alings, {Marco W} and Arnold, {Alfred E R} and {de Boer}, Menko-Jan and Gorgels, {Anton P M} and Michels, {H Rolf} and Agnes Verkerk and Verheugt, {Freek W A} and Felix Zijlstra and Wilde, {Arthur A M}",

year = "2006",

month = sep,

day = "12",

doi = "10.1161/CIRCULATIONAHA.105.606145",

language = "English",

volume = "114",

pages = "1140--5",

journal = "Circulation",

issn = "0009-7322",

publisher = "Lippincott Williams & Wilkins",

number = "11",

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Dekker, LRC, Bezzina, CR, Henriques, JPS, Tanck, MW, Koch, KT, Alings, MW, Arnold, AER, de Boer, M-J, Gorgels, APM, Michels, HR, Verkerk, A, Verheugt, FWA, Zijlstra, F & Wilde, AAM 2006, 'Familial sudden death is an important risk factor for primary ventricular fibrillation: a case-control study in acute myocardial infarction patients', Circulation, vol. 114, no. 11, pp. 1140-5. https://doi.org/10.1161/CIRCULATIONAHA.105.606145

TY - JOUR

T1 - Familial sudden death is an important risk factor for primary ventricular fibrillation

T2 - a case-control study in acute myocardial infarction patients

AU - Dekker, Lukas R C

AU - Bezzina, Connie R

AU - Henriques, José P S

AU - Tanck, Michael W

AU - Koch, Karel T

AU - Alings, Marco W

AU - Arnold, Alfred E R

AU - de Boer, Menko-Jan

AU - Gorgels, Anton P M

AU - Michels, H Rolf

AU - Verkerk, Agnes

AU - Verheugt, Freek W A

AU - Zijlstra, Felix

AU - Wilde, Arthur A M

PY - 2006/9/12

Y1 - 2006/9/12

N2 - BACKGROUND: Primary ventricular fibrillation (VF) accounts for the majority of deaths during the acute phase of myocardial infarction. Identification of patients at risk for primary VF remains very poor.METHODS AND RESULTS: We performed a case-control study in patients with a first ST-elevation myocardial infarction (STEMI) to identify independent risk factors for primary VF. A total of 330 primary VF survivors (cases) and 372 controls were included; patients with earlier infarcts or signs of structural heart disease were excluded. Baseline characteristics, including age, gender, drug use, and ECG parameters registered well before the index infarction, as well as medical history, were not different. Infarct size and location, culprit coronary artery, and presence of multivessel disease were similar between groups. Analysis of ECGs performed at hospital admission for the index STEMI revealed that cumulative ST deviation was significantly higher among cases (OR per 10-mm ST deviation 1.59, 95% CI 1.25 to 2.02). Analysis of medical histories among parents and siblings showed that the prevalence of cardiovascular disease was similar between cases and controls (73.1% and 73.0%, respectively); however, familial sudden death occurred significantly more frequently among cases than controls (43.1% and 25.1%, respectively; OR 2.72, 95% CI 1.84 to 4.03).CONCLUSIONS: In a population of STEMI patients, the risk of primary VF is determined by cumulative ST deviation and family history of sudden death.

AB - BACKGROUND: Primary ventricular fibrillation (VF) accounts for the majority of deaths during the acute phase of myocardial infarction. Identification of patients at risk for primary VF remains very poor.METHODS AND RESULTS: We performed a case-control study in patients with a first ST-elevation myocardial infarction (STEMI) to identify independent risk factors for primary VF. A total of 330 primary VF survivors (cases) and 372 controls were included; patients with earlier infarcts or signs of structural heart disease were excluded. Baseline characteristics, including age, gender, drug use, and ECG parameters registered well before the index infarction, as well as medical history, were not different. Infarct size and location, culprit coronary artery, and presence of multivessel disease were similar between groups. Analysis of ECGs performed at hospital admission for the index STEMI revealed that cumulative ST deviation was significantly higher among cases (OR per 10-mm ST deviation 1.59, 95% CI 1.25 to 2.02). Analysis of medical histories among parents and siblings showed that the prevalence of cardiovascular disease was similar between cases and controls (73.1% and 73.0%, respectively); however, familial sudden death occurred significantly more frequently among cases than controls (43.1% and 25.1%, respectively; OR 2.72, 95% CI 1.84 to 4.03).CONCLUSIONS: In a population of STEMI patients, the risk of primary VF is determined by cumulative ST deviation and family history of sudden death.

KW - Adult

KW - Aged

KW - Arrhythmias, Cardiac/complications

KW - Case-Control Studies

KW - Death, Sudden, Cardiac/etiology

KW - Electrocardiography

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Myocardial Infarction/complications

KW - Netherlands

KW - Phenotype

KW - Risk Assessment

KW - Risk Factors

KW - Survival Rate

KW - Ventricular Fibrillation/complications

U2 - 10.1161/CIRCULATIONAHA.105.606145

DO - 10.1161/CIRCULATIONAHA.105.606145

M3 - Article

C2 - 16940195

SN - 0009-7322

VL - 114

SP - 1140

EP - 1145

JO - Circulation

JF - Circulation

IS - 11

ER -

Familial sudden death is an important risk factor for primary ventricular fibrillation: a case-control study in acute myocardial infarction patients

Abstract

Keywords

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