Falsely decreased ferritin concentrations in two patients with haemophagocytic lymphohistiocytosis: A case report

Geert Roozen; Ingrid Revet; Reinier Raymakers; Hans Kemperman

doi:10.1177/0004563218793166

Falsely decreased ferritin concentrations in two patients with haemophagocytic lymphohistiocytosis: A case report

Geert Roozen
, Ingrid Revet
, Reinier Raymakers
, Hans Kemperman

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The high-dose hook effect, or prozone effect, can lead to negative or falsely lowered plasma ferritin results. Here, cases of a 16-year-old boy and a 70-year-old woman with haemophagocytic lymphohystiocytosis with extremely high concentrations of plasma ferritin (387,000 μg/L and 138,000 μg/L, respectively) are presented. In both cases, falsely lowered ferritin results were reported without any analyser flag. This article emphasizes the importance of recognition of the high-dose hook effect, since a watertight solution is lacking.

Original language	English
Pages (from-to)	179-182
Number of pages	4
Journal	Annals of Clinical Biochemistry
Volume	56
Issue number	1
Early online date	9 Aug 2018
DOIs	https://doi.org/10.1177/0004563218793166
Publication status	Published - Jan 2019

Keywords

ferritin
haemophagocytic lymphohistiocytosis
High-dose hook
prozone
Humans
Male
False Positive Reactions
Adolescent
Lymphohistiocytosis, Hemophagocytic/blood
Female
Aged
Ferritins/blood

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title = "Falsely decreased ferritin concentrations in two patients with haemophagocytic lymphohistiocytosis: A case report",

abstract = "The high-dose hook effect, or prozone effect, can lead to negative or falsely lowered plasma ferritin results. Here, cases of a 16-year-old boy and a 70-year-old woman with haemophagocytic lymphohystiocytosis with extremely high concentrations of plasma ferritin (387,000 μg/L and 138,000 μg/L, respectively) are presented. In both cases, falsely lowered ferritin results were reported without any analyser flag. This article emphasizes the importance of recognition of the high-dose hook effect, since a watertight solution is lacking.",

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AU - Revet, Ingrid

AU - Raymakers, Reinier

AU - Kemperman, Hans

PY - 2019/1

Y1 - 2019/1

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AB - The high-dose hook effect, or prozone effect, can lead to negative or falsely lowered plasma ferritin results. Here, cases of a 16-year-old boy and a 70-year-old woman with haemophagocytic lymphohystiocytosis with extremely high concentrations of plasma ferritin (387,000 μg/L and 138,000 μg/L, respectively) are presented. In both cases, falsely lowered ferritin results were reported without any analyser flag. This article emphasizes the importance of recognition of the high-dose hook effect, since a watertight solution is lacking.

KW - ferritin

KW - haemophagocytic lymphohistiocytosis

KW - High-dose hook

KW - prozone

KW - Humans

KW - Male

KW - False Positive Reactions

KW - Adolescent

KW - Lymphohistiocytosis, Hemophagocytic/blood

KW - Female

KW - Aged

KW - Ferritins/blood

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DO - 10.1177/0004563218793166

M3 - Article

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SN - 0004-5632

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SP - 179

EP - 182

JO - Annals of Clinical Biochemistry

JF - Annals of Clinical Biochemistry

IS - 1

ER -

Falsely decreased ferritin concentrations in two patients with haemophagocytic lymphohistiocytosis: A case report

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