Failing immune control as a result of impaired CD8+ T-cell maturation: CD27 might provide a clue

Debbie van Baarle; Stefan Kostense; Marinus H J van Oers; Dorte Hamann; Frank Miedema

doi:10.1016/s1471-4906(02)02326-8

Failing immune control as a result of impaired CD8+ T-cell maturation: CD27 might provide a clue

Debbie van Baarle, Stefan Kostense, Marinus H J van Oers, Dorte Hamann, Frank Miedema

Research output: Contribution to journal › Review article › peer-review

Abstract

Despite readily detectable virus-specific CD8(+) T cells in most HIV-infected patients, immune surveillance is eventually lost, leading to progression to AIDS. Recently developed insights into human T-cell differentiation have been used to study the phenotype of virus-specific T cells in HIV-infected individuals. Based on these results, we propose that failing immune control in human viral infection could be a result of impaired cytotoxic T-lymphocyte (CTL) maturation into fully differentiated effector T cells. Impaired maturation is not confined to HIV-specific CD8(+) T cells but could also be involved in failing immunity to Epstein-Barr virus and other viral infections. We postulate that CD27(-) effector CD8(+) T cells might be required for adequate control of chronic viral infection and prevention of disease development.

Original language	English
Pages (from-to)	586-91
Number of pages	6
Journal	Trends in immunology
Volume	23
Issue number	12
DOIs	https://doi.org/10.1016/s1471-4906(02)02326-8
Publication status	Published - Dec 2002
Externally published	Yes

Keywords

CD8-Positive T-Lymphocytes/immunology
Cell Differentiation
Epstein-Barr Virus Infections/immunology
HIV Infections/immunology
Humans
Models, Immunological
T-Lymphocytes, Cytotoxic/immunology
Tumor Necrosis Factor Receptor Superfamily, Member 7/metabolism
Virus Diseases/immunology

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10.1016/s1471-4906(02)02326-8

Cite this

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title = "Failing immune control as a result of impaired CD8+ T-cell maturation: CD27 might provide a clue",

abstract = "Despite readily detectable virus-specific CD8(+) T cells in most HIV-infected patients, immune surveillance is eventually lost, leading to progression to AIDS. Recently developed insights into human T-cell differentiation have been used to study the phenotype of virus-specific T cells in HIV-infected individuals. Based on these results, we propose that failing immune control in human viral infection could be a result of impaired cytotoxic T-lymphocyte (CTL) maturation into fully differentiated effector T cells. Impaired maturation is not confined to HIV-specific CD8(+) T cells but could also be involved in failing immunity to Epstein-Barr virus and other viral infections. We postulate that CD27(-) effector CD8(+) T cells might be required for adequate control of chronic viral infection and prevention of disease development.",

keywords = "CD8-Positive T-Lymphocytes/immunology, Cell Differentiation, Epstein-Barr Virus Infections/immunology, HIV Infections/immunology, Humans, Models, Immunological, T-Lymphocytes, Cytotoxic/immunology, Tumor Necrosis Factor Receptor Superfamily, Member 7/metabolism, Virus Diseases/immunology",

author = "{van Baarle}, Debbie and Stefan Kostense and {van Oers}, {Marinus H J} and Dorte Hamann and Frank Miedema",

year = "2002",

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doi = "10.1016/s1471-4906(02)02326-8",

language = "English",

volume = "23",

pages = "586--91",

journal = "Trends in immunology",

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T1 - Failing immune control as a result of impaired CD8+ T-cell maturation

T2 - CD27 might provide a clue

AU - van Baarle, Debbie

AU - Kostense, Stefan

AU - van Oers, Marinus H J

AU - Hamann, Dorte

AU - Miedema, Frank

PY - 2002/12

Y1 - 2002/12

N2 - Despite readily detectable virus-specific CD8(+) T cells in most HIV-infected patients, immune surveillance is eventually lost, leading to progression to AIDS. Recently developed insights into human T-cell differentiation have been used to study the phenotype of virus-specific T cells in HIV-infected individuals. Based on these results, we propose that failing immune control in human viral infection could be a result of impaired cytotoxic T-lymphocyte (CTL) maturation into fully differentiated effector T cells. Impaired maturation is not confined to HIV-specific CD8(+) T cells but could also be involved in failing immunity to Epstein-Barr virus and other viral infections. We postulate that CD27(-) effector CD8(+) T cells might be required for adequate control of chronic viral infection and prevention of disease development.

AB - Despite readily detectable virus-specific CD8(+) T cells in most HIV-infected patients, immune surveillance is eventually lost, leading to progression to AIDS. Recently developed insights into human T-cell differentiation have been used to study the phenotype of virus-specific T cells in HIV-infected individuals. Based on these results, we propose that failing immune control in human viral infection could be a result of impaired cytotoxic T-lymphocyte (CTL) maturation into fully differentiated effector T cells. Impaired maturation is not confined to HIV-specific CD8(+) T cells but could also be involved in failing immunity to Epstein-Barr virus and other viral infections. We postulate that CD27(-) effector CD8(+) T cells might be required for adequate control of chronic viral infection and prevention of disease development.

KW - CD8-Positive T-Lymphocytes/immunology

KW - Cell Differentiation

KW - Epstein-Barr Virus Infections/immunology

KW - HIV Infections/immunology

KW - Humans

KW - Models, Immunological

KW - T-Lymphocytes, Cytotoxic/immunology

KW - Tumor Necrosis Factor Receptor Superfamily, Member 7/metabolism

KW - Virus Diseases/immunology

U2 - 10.1016/s1471-4906(02)02326-8

DO - 10.1016/s1471-4906(02)02326-8

M3 - Review article

C2 - 12464570

SN - 1471-4906

VL - 23

SP - 586

EP - 591

JO - Trends in immunology

JF - Trends in immunology

IS - 12

ER -

Failing immune control as a result of impaired CD8+ T-cell maturation: CD27 might provide a clue

Abstract

Keywords

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