Factors that influence outcomes in cochlear implantation in adults, based on patient related characteristics - a retrospective study

Véronique J C Kraaijenga; Adriana L Smit; Inge Stegeman; Jeanet J M Smilde; G A van Zanten; Wilko Grolman

doi:10.1111/coa.12571

Factors that influence outcomes in cochlear implantation in adults, based on patient related characteristics - a retrospective study

Véronique J C Kraaijenga, Adriana L Smit, Inge Stegeman, Jeanet J M Smilde, G A van Zanten, Wilko Grolman

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: Outcomes in speech perception following cochlear implantation in adults vary widely. Many studies have been carried out to identify and quantify factors that influence outcomes. This paper adds a new dimension to pre-existing literature.

DESIGN: Single center retrospective cohort study.

SETTING: University Medical Center Utrecht, The Netherlands.

PARTICIPANTS: 428 adults with bilateral severe-to-profound sensorineural hearing loss, unilaterally implanted between February 1988 and March 2014.

MAIN OUTCOME MEASURES: Univariable and multivariable linear regression analyses was carried out to identify factors that may influence outcomes from cochlear implantation. Consonant-vowel-consonant' word scores (CNCs) were recorded pre- and post-implant and were used as outcome measures in two groups of patients (pre- and postlingually deafened adults). As an added dimension, multiple imputation was implemented and evaluated to tackle 4% (17/407) missing data.

RESULTS: For postlinguals, pre-implant speech perception score and age at onset of deafness are positive predictors and meningitis and otosclerosis as cause of deafness are negative predictors of post-implant speech perception. This model accounted for 26% of variance. For prelinguals, pre-implant speech perception score is the only strong positive predictor (Beta 0.524; p<0.001). This model accounted for 31% of variance. Age at implantation was not a significant predictor in either group.

CONCLUSIONS: Speech perception is predicted by pre-implant speech perception, age at onset of deafness and etiology (meningitis and otosclerosis) for postlinguals and solely pre-implant speech perception for prelinguals. Age at implantation is of lesser importance in predicting speech perception outcome post-implant. Multiple imputation is a useful statistical techniques when analysing incomplete data sets. This article is protected by copyright. All rights reserved.

Original language	English
Pages (from-to)	585–592
Journal	Clinical Otolaryngology
Volume	41
Issue number	5
DOIs	https://doi.org/10.1111/coa.12571
Publication status	Published - Oct 2016

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@article{4ac19164193c48b08eaea8c11dd6376f,

title = "Factors that influence outcomes in cochlear implantation in adults, based on patient related characteristics - a retrospective study",

abstract = "OBJECTIVE: Outcomes in speech perception following cochlear implantation in adults vary widely. Many studies have been carried out to identify and quantify factors that influence outcomes. This paper adds a new dimension to pre-existing literature.DESIGN: Single center retrospective cohort study.SETTING: University Medical Center Utrecht, The Netherlands.PARTICIPANTS: 428 adults with bilateral severe-to-profound sensorineural hearing loss, unilaterally implanted between February 1988 and March 2014.MAIN OUTCOME MEASURES: Univariable and multivariable linear regression analyses was carried out to identify factors that may influence outcomes from cochlear implantation. Consonant-vowel-consonant' word scores (CNCs) were recorded pre- and post-implant and were used as outcome measures in two groups of patients (pre- and postlingually deafened adults). As an added dimension, multiple imputation was implemented and evaluated to tackle 4% (17/407) missing data.RESULTS: For postlinguals, pre-implant speech perception score and age at onset of deafness are positive predictors and meningitis and otosclerosis as cause of deafness are negative predictors of post-implant speech perception. This model accounted for 26% of variance. For prelinguals, pre-implant speech perception score is the only strong positive predictor (Beta 0.524; p<0.001). This model accounted for 31% of variance. Age at implantation was not a significant predictor in either group.CONCLUSIONS: Speech perception is predicted by pre-implant speech perception, age at onset of deafness and etiology (meningitis and otosclerosis) for postlinguals and solely pre-implant speech perception for prelinguals. Age at implantation is of lesser importance in predicting speech perception outcome post-implant. Multiple imputation is a useful statistical techniques when analysing incomplete data sets. This article is protected by copyright. All rights reserved.",

author = "Kraaijenga, {V{\'e}ronique J C} and Smit, {Adriana L} and Inge Stegeman and Smilde, {Jeanet J M} and {van Zanten}, {G A} and Wilko Grolman",

year = "2016",

month = oct,

doi = "10.1111/coa.12571",

language = "English",

volume = "41",

pages = " 585–592",

journal = "Clinical Otolaryngology",

issn = "1749-4478",

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T1 - Factors that influence outcomes in cochlear implantation in adults, based on patient related characteristics - a retrospective study

AU - Kraaijenga, Véronique J C

AU - Smit, Adriana L

AU - Stegeman, Inge

AU - Smilde, Jeanet J M

AU - van Zanten, G A

AU - Grolman, Wilko

PY - 2016/10

Y1 - 2016/10

N2 - OBJECTIVE: Outcomes in speech perception following cochlear implantation in adults vary widely. Many studies have been carried out to identify and quantify factors that influence outcomes. This paper adds a new dimension to pre-existing literature.DESIGN: Single center retrospective cohort study.SETTING: University Medical Center Utrecht, The Netherlands.PARTICIPANTS: 428 adults with bilateral severe-to-profound sensorineural hearing loss, unilaterally implanted between February 1988 and March 2014.MAIN OUTCOME MEASURES: Univariable and multivariable linear regression analyses was carried out to identify factors that may influence outcomes from cochlear implantation. Consonant-vowel-consonant' word scores (CNCs) were recorded pre- and post-implant and were used as outcome measures in two groups of patients (pre- and postlingually deafened adults). As an added dimension, multiple imputation was implemented and evaluated to tackle 4% (17/407) missing data.RESULTS: For postlinguals, pre-implant speech perception score and age at onset of deafness are positive predictors and meningitis and otosclerosis as cause of deafness are negative predictors of post-implant speech perception. This model accounted for 26% of variance. For prelinguals, pre-implant speech perception score is the only strong positive predictor (Beta 0.524; p<0.001). This model accounted for 31% of variance. Age at implantation was not a significant predictor in either group.CONCLUSIONS: Speech perception is predicted by pre-implant speech perception, age at onset of deafness and etiology (meningitis and otosclerosis) for postlinguals and solely pre-implant speech perception for prelinguals. Age at implantation is of lesser importance in predicting speech perception outcome post-implant. Multiple imputation is a useful statistical techniques when analysing incomplete data sets. This article is protected by copyright. All rights reserved.

AB - OBJECTIVE: Outcomes in speech perception following cochlear implantation in adults vary widely. Many studies have been carried out to identify and quantify factors that influence outcomes. This paper adds a new dimension to pre-existing literature.DESIGN: Single center retrospective cohort study.SETTING: University Medical Center Utrecht, The Netherlands.PARTICIPANTS: 428 adults with bilateral severe-to-profound sensorineural hearing loss, unilaterally implanted between February 1988 and March 2014.MAIN OUTCOME MEASURES: Univariable and multivariable linear regression analyses was carried out to identify factors that may influence outcomes from cochlear implantation. Consonant-vowel-consonant' word scores (CNCs) were recorded pre- and post-implant and were used as outcome measures in two groups of patients (pre- and postlingually deafened adults). As an added dimension, multiple imputation was implemented and evaluated to tackle 4% (17/407) missing data.RESULTS: For postlinguals, pre-implant speech perception score and age at onset of deafness are positive predictors and meningitis and otosclerosis as cause of deafness are negative predictors of post-implant speech perception. This model accounted for 26% of variance. For prelinguals, pre-implant speech perception score is the only strong positive predictor (Beta 0.524; p<0.001). This model accounted for 31% of variance. Age at implantation was not a significant predictor in either group.CONCLUSIONS: Speech perception is predicted by pre-implant speech perception, age at onset of deafness and etiology (meningitis and otosclerosis) for postlinguals and solely pre-implant speech perception for prelinguals. Age at implantation is of lesser importance in predicting speech perception outcome post-implant. Multiple imputation is a useful statistical techniques when analysing incomplete data sets. This article is protected by copyright. All rights reserved.

U2 - 10.1111/coa.12571

DO - 10.1111/coa.12571

M3 - Article

C2 - 26493690

SN - 1749-4478

VL - 41

SP - 585

EP - 592

JO - Clinical Otolaryngology

JF - Clinical Otolaryngology

IS - 5

ER -

Factors that influence outcomes in cochlear implantation in adults, based on patient related characteristics - a retrospective study

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