TY - JOUR
T1 - Factors associated with masticatory function as measured with the Mixing Ability Test in patients with head and neck cancer before and after treatment
T2 - a prospective cohort study
AU - Vermaire, Jorine A.
AU - Raaijmakers, Cornelis P.J.
AU - Monninkhof, Evelyn M.
AU - Leeuw, Irma M.Verdonck de
AU - Terhaard, Chris H.J.
AU - Speksnijder, Caroline M.
N1 - Funding Information:
This study was carried out using the research infrastructure within the NET-QUBIC project (NETherlands QUality of life and BIomedical Cohort studies in Head and Neck Cancer) sponsored by the Dutch Cancer Society/Alpe d’HuZes (grant number VU 2013–5930).
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/5
Y1 - 2022/5
N2 - Purpose: After treatment for head and neck cancer (HNC), patients often experience major problems in masticatory function. The aim of this prospective cohort study among patients with HNC was to investigate which personal and clinical factors are associated with masticatory function from diagnosis up to 2 years after treatment with curative intent. Methods: Masticatory function was measured using the Mixing Ability Test (MAT) before treatment (baseline), and 3, 6, 12, and 24 months after treatment. A linear mixed-effects model with a random intercept and slope was conducted to investigate changes over time and the association with personal (sex, age) and clinical (tumor site, tumor stage, treatment modality) factors as measured at baseline. Result: One-hundred-twenty-five patients were included. The prevalence of masticatory dysfunction was estimated at 29% at M0, 38% at M3, 28% at M6, 26% at M12, and 36% at M24. A higher (worse) MAT score was associated with age, tumor stage, tumor site, timing of assessment, and the interaction between assessment moment and tumor site. Conclusion: In patients with HNC, masticatory function changed over time and dysfunction was associated with a higher age, a tumor in the oral cavity, a higher tumor stage, and a shorter time since treatment. The prevalence of masticatory dysfunction ranged from 26 to 38%.
AB - Purpose: After treatment for head and neck cancer (HNC), patients often experience major problems in masticatory function. The aim of this prospective cohort study among patients with HNC was to investigate which personal and clinical factors are associated with masticatory function from diagnosis up to 2 years after treatment with curative intent. Methods: Masticatory function was measured using the Mixing Ability Test (MAT) before treatment (baseline), and 3, 6, 12, and 24 months after treatment. A linear mixed-effects model with a random intercept and slope was conducted to investigate changes over time and the association with personal (sex, age) and clinical (tumor site, tumor stage, treatment modality) factors as measured at baseline. Result: One-hundred-twenty-five patients were included. The prevalence of masticatory dysfunction was estimated at 29% at M0, 38% at M3, 28% at M6, 26% at M12, and 36% at M24. A higher (worse) MAT score was associated with age, tumor stage, tumor site, timing of assessment, and the interaction between assessment moment and tumor site. Conclusion: In patients with HNC, masticatory function changed over time and dysfunction was associated with a higher age, a tumor in the oral cavity, a higher tumor stage, and a shorter time since treatment. The prevalence of masticatory dysfunction ranged from 26 to 38%.
KW - Associative model
KW - Head and neck cancer
KW - Linear mixed-effects model
KW - Mastication
KW - Mixing Ability Test
UR - http://www.scopus.com/inward/record.url?scp=85123988394&partnerID=8YFLogxK
U2 - 10.1007/s00520-022-06867-0
DO - 10.1007/s00520-022-06867-0
M3 - Article
C2 - 35106658
AN - SCOPUS:85123988394
SN - 0941-4355
VL - 30
SP - 4429
EP - 4436
JO - Supportive Care in Cancer
JF - Supportive Care in Cancer
IS - 5
ER -