Factors associated with cancer worries in individuals participating in annual pancreatic cancer surveillance

Ingrid C A W Konings; Femme Harinck; Marianne A Kuenen; Grace N Sidharta; Jacobien M Kieffer; Cora M Aalfs; Jan-Werner Poley; Ellen M A Smets; Anja Wagner; Anja van Rens; Frank P Vleggaar; Margreet G E M Ausems; Paul Fockens; Jeanin E van Hooft; Marco J Bruno; Eveline M A Bleiker

doi:10.1007/s10689-016-9930-4

Factors associated with cancer worries in individuals participating in annual pancreatic cancer surveillance

Ingrid C A W Konings, Femme Harinck, Marianne A Kuenen, Grace N Sidharta, Jacobien M Kieffer, Cora M Aalfs, Jan-Werner Poley, Ellen M A Smets, Anja Wagner, Anja van Rens, Frank P Vleggaar, Margreet G E M Ausems, Paul Fockens, Jeanin E van Hooft, Marco J Bruno, Eveline M A Bleiker,

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Abstract

It is important to adequately and timely identify individuals with cancer worries amongst participants in a pancreatic ductal adenocarcinoma (PDAC) surveillance program, because they could benefit from psychosocial support to decrease distress. Therefore, the aim of this study was to assess both psychosocial and clinical factors associated with cancer worries. High-risk individuals participating in PDAC-surveillance were invited to annually complete a cancer worry scale (CWS) questionnaire which was sent after counseling by the clinical geneticist (T0), after intake for participation in PDAC-surveillance (T1), and then annually after every MRI and endoscopic ultrasonography (EUS) (T2 and further). Analyses were performed to identify factors associated with cancer worries in the second year of surveillance (T3). We found a significant intra-individual decrease in cancer worries (β = -0.84, P < 0.001), nevertheless, 33 % of individuals had a CWS-score ≥14 at T3. We found one factor significantly associated with cancer worries at T3: having a family member affected by PDAC <50 years of age (β = 0.22, P = 0.03). The detection of a cystic lesion, a shortened surveillance interval, or undergoing pancreatic surgery did not lead to more cancer worries (P = 0.163, P = 0.33, and P = 0.53, respectively). In conclusion, this study identified 'a family history of PDAC <50 years of age' as the only predictor of cancer worries experienced after 2 years of surveillance in individuals at high risk of developing PDAC. This knowledge could help clinicians to timely identify individuals 'at risk' for high levels of cancer worries who would likely benefit from psychosocial support.

Original language	English
Pages (from-to)	143-151
Number of pages	9
Journal	Familial Cancer
Volume	16
Issue number	1
DOIs	https://doi.org/10.1007/s10689-016-9930-4
Publication status	Published - Jan 2017

Keywords

Cancer worries
High-risk individuals
Pancreatic cancer
Predictive factors
Psychosocial burden
Surveillance

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Konings, I. C. A. W., Harinck, F., Kuenen, M. A., Sidharta, G. N., Kieffer, J. M., Aalfs, C. M., Poley, J.-W., Smets, E. M. A., Wagner, A., van Rens, A., Vleggaar, F. P., Ausems, M. G. E. M., Fockens, P., van Hooft, J. E., Bruno, M. J., Bleiker, E. M. A. (2017). Factors associated with cancer worries in individuals participating in annual pancreatic cancer surveillance. Familial Cancer, 16(1), 143-151. https://doi.org/10.1007/s10689-016-9930-4

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title = "Factors associated with cancer worries in individuals participating in annual pancreatic cancer surveillance",

abstract = "It is important to adequately and timely identify individuals with cancer worries amongst participants in a pancreatic ductal adenocarcinoma (PDAC) surveillance program, because they could benefit from psychosocial support to decrease distress. Therefore, the aim of this study was to assess both psychosocial and clinical factors associated with cancer worries. High-risk individuals participating in PDAC-surveillance were invited to annually complete a cancer worry scale (CWS) questionnaire which was sent after counseling by the clinical geneticist (T0), after intake for participation in PDAC-surveillance (T1), and then annually after every MRI and endoscopic ultrasonography (EUS) (T2 and further). Analyses were performed to identify factors associated with cancer worries in the second year of surveillance (T3). We found a significant intra-individual decrease in cancer worries (β = -0.84, P < 0.001), nevertheless, 33 % of individuals had a CWS-score ≥14 at T3. We found one factor significantly associated with cancer worries at T3: having a family member affected by PDAC <50 years of age (β = 0.22, P = 0.03). The detection of a cystic lesion, a shortened surveillance interval, or undergoing pancreatic surgery did not lead to more cancer worries (P = 0.163, P = 0.33, and P = 0.53, respectively). In conclusion, this study identified 'a family history of PDAC <50 years of age' as the only predictor of cancer worries experienced after 2 years of surveillance in individuals at high risk of developing PDAC. This knowledge could help clinicians to timely identify individuals 'at risk' for high levels of cancer worries who would likely benefit from psychosocial support.",

keywords = "Cancer worries, High-risk individuals, Pancreatic cancer, Predictive factors , Psychosocial burden, Surveillance",

author = "Konings, {Ingrid C A W} and Femme Harinck and Kuenen, {Marianne A} and Sidharta, {Grace N} and Kieffer, {Jacobien M} and Aalfs, {Cora M} and Jan-Werner Poley and Smets, {Ellen M A} and Anja Wagner and {van Rens}, Anja and Vleggaar, {Frank P} and Ausems, {Margreet G E M} and Paul Fockens and {van Hooft}, {Jeanin E} and Bruno, {Marco J} and Bleiker, {Eveline M A}",

note = "Publisher Copyright: {\textcopyright} 2016, The Author(s).",

year = "2017",

month = jan,

doi = "10.1007/s10689-016-9930-4",

language = "English",

volume = "16",

pages = "143--151",

journal = "Familial Cancer",

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Konings, ICAW, Harinck, F, Kuenen, MA, Sidharta, GN, Kieffer, JM, Aalfs, CM, Poley, J-W, Smets, EMA, Wagner, A, van Rens, A, Vleggaar, FP , Ausems, MGEM, Fockens, P, van Hooft, JE, Bruno, MJ, Bleiker, EMA 2017, 'Factors associated with cancer worries in individuals participating in annual pancreatic cancer surveillance', Familial Cancer, vol. 16, no. 1, pp. 143-151. https://doi.org/10.1007/s10689-016-9930-4

TY - JOUR

T1 - Factors associated with cancer worries in individuals participating in annual pancreatic cancer surveillance

AU - Konings, Ingrid C A W

AU - Harinck, Femme

AU - Kuenen, Marianne A

AU - Sidharta, Grace N

AU - Kieffer, Jacobien M

AU - Aalfs, Cora M

AU - Poley, Jan-Werner

AU - Smets, Ellen M A

AU - Wagner, Anja

AU - van Rens, Anja

AU - Vleggaar, Frank P

AU - Ausems, Margreet G E M

AU - Fockens, Paul

AU - van Hooft, Jeanin E

AU - Bruno, Marco J

AU - Bleiker, Eveline M A

PY - 2017/1

Y1 - 2017/1

N2 - It is important to adequately and timely identify individuals with cancer worries amongst participants in a pancreatic ductal adenocarcinoma (PDAC) surveillance program, because they could benefit from psychosocial support to decrease distress. Therefore, the aim of this study was to assess both psychosocial and clinical factors associated with cancer worries. High-risk individuals participating in PDAC-surveillance were invited to annually complete a cancer worry scale (CWS) questionnaire which was sent after counseling by the clinical geneticist (T0), after intake for participation in PDAC-surveillance (T1), and then annually after every MRI and endoscopic ultrasonography (EUS) (T2 and further). Analyses were performed to identify factors associated with cancer worries in the second year of surveillance (T3). We found a significant intra-individual decrease in cancer worries (β = -0.84, P < 0.001), nevertheless, 33 % of individuals had a CWS-score ≥14 at T3. We found one factor significantly associated with cancer worries at T3: having a family member affected by PDAC <50 years of age (β = 0.22, P = 0.03). The detection of a cystic lesion, a shortened surveillance interval, or undergoing pancreatic surgery did not lead to more cancer worries (P = 0.163, P = 0.33, and P = 0.53, respectively). In conclusion, this study identified 'a family history of PDAC <50 years of age' as the only predictor of cancer worries experienced after 2 years of surveillance in individuals at high risk of developing PDAC. This knowledge could help clinicians to timely identify individuals 'at risk' for high levels of cancer worries who would likely benefit from psychosocial support.

AB - It is important to adequately and timely identify individuals with cancer worries amongst participants in a pancreatic ductal adenocarcinoma (PDAC) surveillance program, because they could benefit from psychosocial support to decrease distress. Therefore, the aim of this study was to assess both psychosocial and clinical factors associated with cancer worries. High-risk individuals participating in PDAC-surveillance were invited to annually complete a cancer worry scale (CWS) questionnaire which was sent after counseling by the clinical geneticist (T0), after intake for participation in PDAC-surveillance (T1), and then annually after every MRI and endoscopic ultrasonography (EUS) (T2 and further). Analyses were performed to identify factors associated with cancer worries in the second year of surveillance (T3). We found a significant intra-individual decrease in cancer worries (β = -0.84, P < 0.001), nevertheless, 33 % of individuals had a CWS-score ≥14 at T3. We found one factor significantly associated with cancer worries at T3: having a family member affected by PDAC <50 years of age (β = 0.22, P = 0.03). The detection of a cystic lesion, a shortened surveillance interval, or undergoing pancreatic surgery did not lead to more cancer worries (P = 0.163, P = 0.33, and P = 0.53, respectively). In conclusion, this study identified 'a family history of PDAC <50 years of age' as the only predictor of cancer worries experienced after 2 years of surveillance in individuals at high risk of developing PDAC. This knowledge could help clinicians to timely identify individuals 'at risk' for high levels of cancer worries who would likely benefit from psychosocial support.

KW - Cancer worries

KW - High-risk individuals

KW - Pancreatic cancer

KW - Predictive factors

KW - Psychosocial burden

KW - Surveillance

U2 - 10.1007/s10689-016-9930-4

DO - 10.1007/s10689-016-9930-4

M3 - Article

C2 - 27629874

SN - 1389-9600

VL - 16

SP - 143

EP - 151

JO - Familial Cancer

JF - Familial Cancer

IS - 1

ER -

Factors associated with cancer worries in individuals participating in annual pancreatic cancer surveillance

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Keywords

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