Factors affecting estrogen receptor status in a multiracial Asian country: An analysis of 3557 cases

C. H. Yip; N. Bhoo Pathy; C. S. Uiterwaal; N. A. Taib; G. H. Tan; K. S. Mun; W. Y. Choo; A. Rhodes

doi:10.1016/j.breast.2011.02.004

Factors affecting estrogen receptor status in a multiracial Asian country: An analysis of 3557 cases

C. H. Yip^*, N. Bhoo Pathy, C. S. Uiterwaal, N. A. Taib, G. H. Tan, K. S. Mun, W. Y. Choo, A. Rhodes

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

18 Citations (Scopus)

Abstract

Estrogen receptor (ER) positive rates in breast cancer may be influenced by grade, stage, age and race. This study reviews the ER positive rates over a 15-year period at the University Malaya Medical Centre, Kuala Lumpur, Malaysia. Data on ER status of 3557 patients from 1994 to 2008 was analyzed. ER status was determined by immunohistochemistry with a cut-off point of 10%. ER positivity increased by about 2% for every 5-year cohort, from 54.5% in 1994-1998 to 58.4% in 2004-2008. Ethnicity and grade were significantly associated with ER positivity rates: Malay women were found to have a higher risk of ER negative tumors compared with Chinese women. Grade 1 cancers were nine times more likely to be ER positive compared with grade 3 cancers. In summary, the proportion of ER positive cancers increased with each time period, and ethnicity and grade were independent factors that influenced ER positive rates.

Original language	English
Journal	Breast
Volume	20
Issue number	SUPPL. 2
DOIs	https://doi.org/10.1016/j.breast.2011.02.004
Publication status	Published - 1 Apr 2011

Keywords

Breast cancer
ER positivity
Middle income country

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10.1016/j.breast.2011.02.004

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@article{dc14d5ed3c8a43a2becc4fb02346df59,

title = "Factors affecting estrogen receptor status in a multiracial Asian country: An analysis of 3557 cases",

abstract = "Estrogen receptor (ER) positive rates in breast cancer may be influenced by grade, stage, age and race. This study reviews the ER positive rates over a 15-year period at the University Malaya Medical Centre, Kuala Lumpur, Malaysia. Data on ER status of 3557 patients from 1994 to 2008 was analyzed. ER status was determined by immunohistochemistry with a cut-off point of 10%. ER positivity increased by about 2% for every 5-year cohort, from 54.5% in 1994-1998 to 58.4% in 2004-2008. Ethnicity and grade were significantly associated with ER positivity rates: Malay women were found to have a higher risk of ER negative tumors compared with Chinese women. Grade 1 cancers were nine times more likely to be ER positive compared with grade 3 cancers. In summary, the proportion of ER positive cancers increased with each time period, and ethnicity and grade were independent factors that influenced ER positive rates.",

keywords = "Breast cancer, ER positivity, Middle income country",

author = "Yip, {C. H.} and {Bhoo Pathy}, N. and Uiterwaal, {C. S.} and Taib, {N. A.} and Tan, {G. H.} and Mun, {K. S.} and Choo, {W. Y.} and A. Rhodes",

year = "2011",

month = apr,

day = "1",

doi = "10.1016/j.breast.2011.02.004",

language = "English",

volume = "20",

journal = "Breast",

issn = "0960-9776",

publisher = "Churchill Livingstone",

number = "SUPPL. 2",

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TY - JOUR

T1 - Factors affecting estrogen receptor status in a multiracial Asian country

T2 - An analysis of 3557 cases

AU - Yip, C. H.

AU - Bhoo Pathy, N.

AU - Uiterwaal, C. S.

AU - Taib, N. A.

AU - Tan, G. H.

AU - Mun, K. S.

AU - Choo, W. Y.

AU - Rhodes, A.

PY - 2011/4/1

Y1 - 2011/4/1

N2 - Estrogen receptor (ER) positive rates in breast cancer may be influenced by grade, stage, age and race. This study reviews the ER positive rates over a 15-year period at the University Malaya Medical Centre, Kuala Lumpur, Malaysia. Data on ER status of 3557 patients from 1994 to 2008 was analyzed. ER status was determined by immunohistochemistry with a cut-off point of 10%. ER positivity increased by about 2% for every 5-year cohort, from 54.5% in 1994-1998 to 58.4% in 2004-2008. Ethnicity and grade were significantly associated with ER positivity rates: Malay women were found to have a higher risk of ER negative tumors compared with Chinese women. Grade 1 cancers were nine times more likely to be ER positive compared with grade 3 cancers. In summary, the proportion of ER positive cancers increased with each time period, and ethnicity and grade were independent factors that influenced ER positive rates.

AB - Estrogen receptor (ER) positive rates in breast cancer may be influenced by grade, stage, age and race. This study reviews the ER positive rates over a 15-year period at the University Malaya Medical Centre, Kuala Lumpur, Malaysia. Data on ER status of 3557 patients from 1994 to 2008 was analyzed. ER status was determined by immunohistochemistry with a cut-off point of 10%. ER positivity increased by about 2% for every 5-year cohort, from 54.5% in 1994-1998 to 58.4% in 2004-2008. Ethnicity and grade were significantly associated with ER positivity rates: Malay women were found to have a higher risk of ER negative tumors compared with Chinese women. Grade 1 cancers were nine times more likely to be ER positive compared with grade 3 cancers. In summary, the proportion of ER positive cancers increased with each time period, and ethnicity and grade were independent factors that influenced ER positive rates.

KW - Breast cancer

KW - ER positivity

KW - Middle income country

UR - http://www.scopus.com/inward/record.url?scp=79953046869&partnerID=8YFLogxK

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DO - 10.1016/j.breast.2011.02.004

M3 - Article

C2 - 21349715

AN - SCOPUS:79953046869

SN - 0960-9776

VL - 20

JO - Breast

JF - Breast

IS - SUPPL. 2

ER -

Factors affecting estrogen receptor status in a multiracial Asian country: An analysis of 3557 cases

Abstract

Keywords

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