Extravasation of an antibody-drug conjugate: A case report of epidermal necrosis after trastuzumab-emtansine extravasation

Bastiaan T G M Sallevelt; Teun Teunis; Mariette J Agterof; Marcel P H van den Broek

doi:10.1111/jcpt.13148

Extravasation of an antibody-drug conjugate: A case report of epidermal necrosis after trastuzumab-emtansine extravasation

Bastiaan T G M Sallevelt, Teun Teunis, Mariette J Agterof, Marcel P H van den Broek

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Abstract

WHAT IS KNOWN AND OBJECTIVE: Trastuzumab-emtansine is an antibody-drug conjugate developed to decrease off-target toxicity. According to the product label, reactions secondary to extravasation are mild or moderate.

CASE SUMMARY: We report on a 51-year-old woman who developed epidermal necrosis after extravasation of trastuzumab-emtansine, which required surgical intervention. Six weeks later, the lesions were healed with residual hyperpigmentation.

WHAT IS NEW AND CONCLUSION: We describe the course of a case of severe toxicity following trastuzumab-emtansine extravasation. We provide treatment recommendations and recommend amending the information on the product label on extravasation.

Original language	English
Pages (from-to)	832-835
Number of pages	4
Journal	Journal of Clinical Pharmacy and Therapeutics
Volume	45
Issue number	4
DOIs	https://doi.org/10.1111/jcpt.13148
Publication status	Published - Aug 2020

Keywords

antibody-drug conjugate
chemotherapy
epidermal necrosis
extravasation
oncology
trastuzumab-emtansine

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title = "Extravasation of an antibody-drug conjugate: A case report of epidermal necrosis after trastuzumab-emtansine extravasation",

abstract = "WHAT IS KNOWN AND OBJECTIVE: Trastuzumab-emtansine is an antibody-drug conjugate developed to decrease off-target toxicity. According to the product label, reactions secondary to extravasation are mild or moderate.CASE SUMMARY: We report on a 51-year-old woman who developed epidermal necrosis after extravasation of trastuzumab-emtansine, which required surgical intervention. Six weeks later, the lesions were healed with residual hyperpigmentation.WHAT IS NEW AND CONCLUSION: We describe the course of a case of severe toxicity following trastuzumab-emtansine extravasation. We provide treatment recommendations and recommend amending the information on the product label on extravasation.",

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author = "Sallevelt, \{Bastiaan T G M\} and Teun Teunis and Agterof, \{Mariette J\} and \{van den Broek\}, \{Marcel P H\}",

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year = "2020",

month = aug,

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language = "English",

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AU - Teunis, Teun

AU - Agterof, Mariette J

AU - van den Broek, Marcel P H

PY - 2020/8

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KW - chemotherapy

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KW - oncology

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Extravasation of an antibody-drug conjugate: A case report of epidermal necrosis after trastuzumab-emtansine extravasation

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Keywords

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