TY - JOUR
T1 - Extracranial carotid disease and effect of intra-arterial treatment in patients with proximal anterior circulation stroke in MR CLEAN
AU - Vos, Jan Albert
AU - Van Walderveen, Marianne A.A.
AU - Staals, Julie
AU - Hofmeijer, Jeannette
AU - Van Oostayen, Jacques A.
AU - Lycklama À Nijeholt, Geert J.
AU - Boiten, Jelis
AU - Brouwer, Patrick A.
AU - De Bruijn, Sebastiaan F.
AU - Van Dijk, Lukas C.
AU - Kappelle, L. Jaap
AU - Lo, Rob H.
AU - Van Dijk, Ewoud J.
AU - De Vries, Joost
AU - De Kort, Paul L.M.
AU - Van Den Berg, Jan S.P.
AU - Van Rooij, Willem Jan J.
AU - Van Hasselt, Boudewijn A.A.M.
AU - Aerden, Leo A.M.
AU - Dallinga, René J.
AU - Visser, Marieke C.
AU - Bot, Joseph C.J.
AU - Vroomen, Patrick C.
AU - Eshghi, Omid
AU - Schreuder, Tobien H.C.M.L.
AU - Heijboer, Roel J.J.
AU - Keizer, Koos
AU - Tielbeek, Alexander V.
AU - Den Hertog, Heleen M.
AU - Gerrits, Dick G.
AU - Van Den Berg-Vos, Renske M.
AU - Karas, Giorgos B.
AU - Beenen, Ludo F.
AU - Sprengers, Marieke E.S.
AU - Jenniskens, Sjoerd F.M.
AU - Van Den Berg, René
AU - Koudstaal, Peter J.
AU - Flach, H. Zwenneke
AU - Steyerberg, Ewout W.
AU - Berkhemer, Olvert A.
AU - Borst, Jordi
AU - Kappelhof, Manon
AU - Yoo, Albert J.
AU - Van Den Berg, Lucie A.
AU - Fransen, Puck S.S.
AU - Beumer, Debbie
AU - Schonewille, Wouter J.
AU - Nederkoorn, Paul J.
AU - Wermer, Marieke J.H.
AU - Marquering, Henk A.
AU - Lingsma, Hester F.
AU - Roos, Yvo B.W.E.M.
AU - Van Oostenbrugge, Robert J.
AU - Dippel, Diederik W.J.
AU - Van Zwam, Wim H.
AU - Majoie, Charles B.L.M.
AU - Emmer, Bart J.
AU - Van Der Lugt, Aad
PY - 2017/6/20
Y1 - 2017/6/20
N2 - Background: The presence of extracranial carotid disease (ECD) is associated with less favorable clinical outcomes in patients with acute ischemic stroke caused by intracranial proximal occlusion. Acute intra-arterial treatment (IAT) in the setting of extracranial and intracranial lesions is considered challenging, and whether it yields improved outcomes remains uncertain.Objective: To examine whether the presence of ECD modified the effect of IAT for intracranial proximal anterior circulation occlusion.Design: Prespecified subgroup analysis of a randomized clinical trial of endovascular treatment for acute ischemic stroke in the Netherlands. (Trial registrations: NTR1804 [Netherlands Trial Register] and ISRCTN10888758).Setting: 16 hospitals in the Netherlands.Patients: Acute ischemic stroke caused by proximal intracranial arterial occlusion of the anterior circulation. Extracranial carotid disease was defined as cervical internal carotid artery stenosis (>50%) or occlusion.Intervention: IAT treatment versus no IAT.Measurements: The primary outcome was functional outcome, as measured by the modified Rankin Scale at 90 days and reported as adjusted common odds ratio (acOR) for a shift in direction of a better outcome. Multivariable ordinal logistic regression analysis with an interaction term was used to estimate treatment effect modification by ECD.Results: The overall acOR was 1.67 (95% CI, 1.21 to 2.30) in favor of the intervention. The acOR was 3.1 (CI, 1.7 to 5.8) in the prespecified subgroup of patients with ECD versus 1.3 (CI, 0.9 to 1.9) in patients presenting without ECD. Both acORs are in favor of the intervention (P for interaction = 0.07).Limitation: The study was not powered for subgroup analysis.Conclusion: Intra-arterial treatment may be at least as effective in patients with ECD as in those without ECD, and it should not be withheld in these complex patients with acute ischemic stroke.Primary Funding Source: Dutch Heart Foundation, AngioCare BV, Medtronic/Covidien/EV3, MEDAC Gmbh/LAMEPRO, Penumbra, Stryker, and Top Medical/Concentric.
AB - Background: The presence of extracranial carotid disease (ECD) is associated with less favorable clinical outcomes in patients with acute ischemic stroke caused by intracranial proximal occlusion. Acute intra-arterial treatment (IAT) in the setting of extracranial and intracranial lesions is considered challenging, and whether it yields improved outcomes remains uncertain.Objective: To examine whether the presence of ECD modified the effect of IAT for intracranial proximal anterior circulation occlusion.Design: Prespecified subgroup analysis of a randomized clinical trial of endovascular treatment for acute ischemic stroke in the Netherlands. (Trial registrations: NTR1804 [Netherlands Trial Register] and ISRCTN10888758).Setting: 16 hospitals in the Netherlands.Patients: Acute ischemic stroke caused by proximal intracranial arterial occlusion of the anterior circulation. Extracranial carotid disease was defined as cervical internal carotid artery stenosis (>50%) or occlusion.Intervention: IAT treatment versus no IAT.Measurements: The primary outcome was functional outcome, as measured by the modified Rankin Scale at 90 days and reported as adjusted common odds ratio (acOR) for a shift in direction of a better outcome. Multivariable ordinal logistic regression analysis with an interaction term was used to estimate treatment effect modification by ECD.Results: The overall acOR was 1.67 (95% CI, 1.21 to 2.30) in favor of the intervention. The acOR was 3.1 (CI, 1.7 to 5.8) in the prespecified subgroup of patients with ECD versus 1.3 (CI, 0.9 to 1.9) in patients presenting without ECD. Both acORs are in favor of the intervention (P for interaction = 0.07).Limitation: The study was not powered for subgroup analysis.Conclusion: Intra-arterial treatment may be at least as effective in patients with ECD as in those without ECD, and it should not be withheld in these complex patients with acute ischemic stroke.Primary Funding Source: Dutch Heart Foundation, AngioCare BV, Medtronic/Covidien/EV3, MEDAC Gmbh/LAMEPRO, Penumbra, Stryker, and Top Medical/Concentric.
KW - Aged
KW - Brain Ischemia/etiology
KW - Carotid Stenosis/complications
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Postoperative Complications
KW - Stroke/etiology
KW - Treatment Outcome
UR - http://www.scopus.com/inward/record.url?scp=85021103551&partnerID=8YFLogxK
U2 - 10.7326/M16-1536
DO - 10.7326/M16-1536
M3 - Article
C2 - 28531910
AN - SCOPUS:85021103551
SN - 0003-4819
VL - 166
SP - 867
EP - 875
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
IS - 12
ER -