TY - JOUR
T1 - Extracellular vesicles
T2 - New tool for joint repair and regeneration
AU - Malda, Jos
AU - Boere, Janneke
AU - van de Lest, Chris H A
AU - van Weeren, P. René
AU - Wauben, Marca H M
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Cell-derived extracellular vesicles (EVs), present in synovial fluid and cartilage extracellular matrix (ECM), are involved in joint development and in the regulation of joint homeostasis. Although the exact function of EVs in these processes remains incompletely defined, the knowledge already acquired in this field suggests a role for these EVs as biomarkers of joint disease, and as a new tool to restore joint homeostasis and enhance articular tissue regeneration. In addition to direct injection of therapeutic EVs into the target site, surface coating of scaffolds and embedding of EVs in hydrogels might also lead to novel therapeutic possibilities. Based on the existing literature of EVs in synovial fluid and articular tissues, and investigation of the molecular factors (including microRNAs) active in joint homeostasis (or during its disturbance), we postulate novel perspectives for the implementation of EVs as a regenerative medicine approach in joint repair.
AB - Cell-derived extracellular vesicles (EVs), present in synovial fluid and cartilage extracellular matrix (ECM), are involved in joint development and in the regulation of joint homeostasis. Although the exact function of EVs in these processes remains incompletely defined, the knowledge already acquired in this field suggests a role for these EVs as biomarkers of joint disease, and as a new tool to restore joint homeostasis and enhance articular tissue regeneration. In addition to direct injection of therapeutic EVs into the target site, surface coating of scaffolds and embedding of EVs in hydrogels might also lead to novel therapeutic possibilities. Based on the existing literature of EVs in synovial fluid and articular tissues, and investigation of the molecular factors (including microRNAs) active in joint homeostasis (or during its disturbance), we postulate novel perspectives for the implementation of EVs as a regenerative medicine approach in joint repair.
UR - http://www.scopus.com/inward/record.url?scp=84953330502&partnerID=8YFLogxK
U2 - 10.1038/nrrheum.2015.170
DO - 10.1038/nrrheum.2015.170
M3 - Article
C2 - 26729461
AN - SCOPUS:84953330502
SN - 1759-4790
VL - 12
SP - 243
EP - 249
JO - Nature Reviews. Rheumatology
JF - Nature Reviews. Rheumatology
IS - 4
ER -