TY - JOUR
T1 - Extracellular vesicles in diagnostics and therapy of the ischaemic heart
T2 - Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology
AU - Sluijter, Joost Petrus Gerardus
AU - Davidson, Sean Michael
AU - Boulanger, Chantal M.
AU - Buzás, Edit Iren
AU - De Kleijn, Dominique Paschalis Victor
AU - Engel, Felix Benedikt
AU - Giricz, Zoltán
AU - Hausenloy, Derek J.
AU - Kishore, Raj
AU - Lecour, Sandrine
AU - Leor, Jonathan
AU - Madonna, Rosalinda
AU - Perrino, Cinzia
AU - Prunier, Fabrice
AU - Sahoo, Susmita
AU - Schiffelers, Ray Michel
AU - Schulz, Rainer
AU - Van Laake, Linda Wilhelmina
AU - Ytrehus, Kirsti
AU - Ferdinandy, Peter
N1 - Publisher Copyright:
© 2017 Author.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Extracellular vesicles (EVs)-particularly exosomes and microvesicles (MVs)-are attracting considerable interest in the cardiovascular field as the wide range of their functions is recognized. These capabilities include transporting regulatory molecules including different RNA species, lipids, and proteins through the extracellular space including blood and delivering these cargos to recipient cells to modify cellular activity. EVs powerfully stimulate angiogenesis, and can protect the heart against myocardial infarction. They also appear to mediate some of the paracrine effects of cells, and have therefore been proposed as a potential alternative to cell-based regenerative therapies. Moreover, EVs of different sources may be useful biomarkers of cardiovascular disease identities. However, the methods used for the detection and isolation of EVs have several limitations and vary widely between studies, leading to uncertainties regarding the exact population of EVs studied and how to interpret the data. The number of publications in the exosome and MV field has been increasing exponentially in recent years and, therefore, in this ESC Working Group Position Paper, the overall objective is to provide a set of recommendations for the analysis and translational application of EVs focussing on the diagnosis and therapy of the ischaemic heart. This should help to ensure that the data from emerging studies are robust and repeatable, and optimize the pathway towards the diagnostic and therapeutic use of EVs in clinical studies for patient benefit.
AB - Extracellular vesicles (EVs)-particularly exosomes and microvesicles (MVs)-are attracting considerable interest in the cardiovascular field as the wide range of their functions is recognized. These capabilities include transporting regulatory molecules including different RNA species, lipids, and proteins through the extracellular space including blood and delivering these cargos to recipient cells to modify cellular activity. EVs powerfully stimulate angiogenesis, and can protect the heart against myocardial infarction. They also appear to mediate some of the paracrine effects of cells, and have therefore been proposed as a potential alternative to cell-based regenerative therapies. Moreover, EVs of different sources may be useful biomarkers of cardiovascular disease identities. However, the methods used for the detection and isolation of EVs have several limitations and vary widely between studies, leading to uncertainties regarding the exact population of EVs studied and how to interpret the data. The number of publications in the exosome and MV field has been increasing exponentially in recent years and, therefore, in this ESC Working Group Position Paper, the overall objective is to provide a set of recommendations for the analysis and translational application of EVs focussing on the diagnosis and therapy of the ischaemic heart. This should help to ensure that the data from emerging studies are robust and repeatable, and optimize the pathway towards the diagnostic and therapeutic use of EVs in clinical studies for patient benefit.
KW - Cardioprotection
KW - Co-morbidities
KW - Exosomes
KW - Extracellular vesicles
KW - Heart failure
KW - Ischaemia
KW - Microvesicles
KW - Postconditioning
KW - Preconditioning
KW - Regenerative medicine
KW - Remote conditioning
KW - Reperfusion
UR - http://www.scopus.com/inward/record.url?scp=85040573770&partnerID=8YFLogxK
U2 - 10.1093/cvr/cvx211
DO - 10.1093/cvr/cvx211
M3 - Review article
C2 - 29106545
SN - 0008-6363
VL - 114
SP - 19
EP - 34
JO - Cardiovascular Research
JF - Cardiovascular Research
IS - 1
ER -