@article{db8464bbb40e4ee98ed6697e82cbf07f,
title = "External validation of prognostic models for preeclampsia in a Dutch multicenter prospective cohort",
abstract = "Objective: To perform an external validation of all published prognostic models for first-trimester prediction of the risk of developing preeclampsia (PE). Methods: Women <14 weeks of pregnancy were recruited in the Netherlands. All systematically identified prognostic models for PE that contained predictors commonly available were eligible for external validation. Results: 3,736 women were included; 87 (2.3\%) developed PE. Calibration was poor due to overestimation. Discrimination of 9 models for LO-PE ranged from 0.58 to 0.71 and of 9 models for all PE from 0.55 to 0.75. Conclusion: Only a few easily applicable prognostic models for all PE showed discrimination above 0.70, which is considered an acceptable performance.",
keywords = "First trimester, external validation, preeclampsia, prognostic model, Models, Theoretical, Prognosis, Prospective Studies, Risk Assessment, Humans, Pre-Eclampsia/diagnosis, Pregnancy, Adult, Female",
author = "\{Lamain-de Ruiter\}, Marije and Anneke Kwee and Naaktgeboren, \{Christiana A\} and Louhanepessy, \{Rebecca D\} and \{De Groot\}, Inge and Evers, \{Inge M\} and Floris Groenendaal and Hering, \{Yolanda R\} and Huisjes, \{Anjoke J M\} and Cornel Kirpestein and Monincx, \{Wilma M\} and Schielen, \{Peter C J I\} and \{Van 't Zelfde\}, Annewil and \{Van Oirschot\}, \{Charlotte M\} and Vankan-Buitelaar, \{Simone A\} and Vonk, \{Mariska A A W\} and Wiegers, \{Therese A\} and Zwart, \{Joost J\} and Moons, \{Karel G M\} and Arie Franx and Koster, \{Maria P H\}",
note = "Funding Information: This work was supported by The Netherlands Organization for Health Research and Development under Grant [project nr 209020004]. Funding Information: This work was supported by The Netherlands Organization for Health Research and Development under Grant [project nr 209020004]. We would like to thank all pregnant women who participated in the RESPECT study. A special thanks to the midwifery practices and hospitals in our regional consortium (GCMN) for their help in recruiting participants and technicians (I. Belmouden, G. Diependaal, M. Jonker, P. Turion, S. Verhoef) of the National Institute for Public Health and the Environment (RIVM) and U. Koster for their help in analyzing the biochemical serum markers. Publisher Copyright: {\textcopyright} 2019, {\textcopyright} 2019 The Author(s). Published by Informa UK Limited, trading as Taylor \& Francis Group.",
year = "2019",
month = mar,
day = "20",
doi = "10.1080/10641955.2019.1584210",
language = "English",
volume = "38",
pages = "78--88",
journal = "Hypertension in Pregnancy",
issn = "1064-1955",
publisher = "Taylor and Francis Ltd.",
number = "2",
}