External validation of prognostic models for preeclampsia in a Dutch multicenter prospective cohort

Marije Lamain-de Ruiter, Anneke Kwee, Christiana A Naaktgeboren, Rebecca D Louhanepessy, Inge De Groot, Inge M Evers, Floris Groenendaal, Yolanda R Hering, Anjoke J M Huisjes, Cornel Kirpestein, Wilma M Monincx, Peter C J I Schielen, Annewil Van 't Zelfde, Charlotte M Van Oirschot, Simone A Vankan-Buitelaar, Mariska A A W Vonk, Therese A Wiegers, Joost J Zwart, Karel G M Moons, Arie FranxMaria P H Koster

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective: To perform an external validation of all published prognostic models for first-trimester prediction of the risk of developing preeclampsia (PE). Methods: Women <14 weeks of pregnancy were recruited in the Netherlands. All systematically identified prognostic models for PE that contained predictors commonly available were eligible for external validation. Results: 3,736 women were included; 87 (2.3%) developed PE. Calibration was poor due to overestimation. Discrimination of 9 models for LO-PE ranged from 0.58 to 0.71 and of 9 models for all PE from 0.55 to 0.75. Conclusion: Only a few easily applicable prognostic models for all PE showed discrimination above 0.70, which is considered an acceptable performance.

Original languageEnglish
Pages (from-to)78-88
Number of pages11
JournalHypertension in Pregnancy
Volume38
Issue number2
DOIs
Publication statusPublished - 20 Mar 2019

Keywords

  • First trimester
  • external validation
  • preeclampsia
  • prognostic model
  • Models, Theoretical
  • Prognosis
  • Prospective Studies
  • Risk Assessment
  • Humans
  • Pre-Eclampsia/diagnosis
  • Pregnancy
  • Adult
  • Female

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