Expression of the glucocorticoid receptor and its isoforms in relation to glucocorticoid resistance in childhood acute lymphocytic leukemia

Wim J.E. Tissing; Melchior Lauten; Jules P.P. Meijerink; Monique L. Den Boer; Jan Willem Koper; Peter Sonneveld; Rob Pieters

Expression of the glucocorticoid receptor and its isoforms in relation to glucocorticoid resistance in childhood acute lymphocytic leukemia

Wim J.E. Tissing, Melchior Lauten, Jules P.P. Meijerink^*, Monique L. Den Boer, Jan Willem Koper, Peter Sonneveld, Rob Pieters

^*Corresponding author for this work

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Abstract

In vitro prednisolone resistance is a poor prognostic factor in the treatment of childhood acute lymphoblastic leukemia (ALL). In a cohort of 54 children with ALL, a lower expression of the glucocorticoid receptor (GR), but not the relative expression levels of the GR-α, GR-β and GR-P isoforms, was associated with in vitro prednisolone resistance.

Original language	English
Pages (from-to)	1279-1281
Number of pages	3
Journal	Haematologica
Volume	90
Issue number	9
Publication status	Published - 1 Sept 2005

Keywords

Acute lymphoblastic leukemia
Children
Glucocorticoid
Isoforms
Resistance

Cite this

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title = "Expression of the glucocorticoid receptor and its isoforms in relation to glucocorticoid resistance in childhood acute lymphocytic leukemia",

abstract = "In vitro prednisolone resistance is a poor prognostic factor in the treatment of childhood acute lymphoblastic leukemia (ALL). In a cohort of 54 children with ALL, a lower expression of the glucocorticoid receptor (GR), but not the relative expression levels of the GR-α, GR-β and GR-P isoforms, was associated with in vitro prednisolone resistance.",

keywords = "Acute lymphoblastic leukemia, Children, Glucocorticoid, Isoforms, Resistance",

author = "Tissing, {Wim J.E.} and Melchior Lauten and Meijerink, {Jules P.P.} and {Den Boer}, {Monique L.} and Koper, {Jan Willem} and Peter Sonneveld and Rob Pieters",

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T1 - Expression of the glucocorticoid receptor and its isoforms in relation to glucocorticoid resistance in childhood acute lymphocytic leukemia

AU - Tissing, Wim J.E.

AU - Lauten, Melchior

AU - Meijerink, Jules P.P.

AU - Den Boer, Monique L.

AU - Koper, Jan Willem

AU - Sonneveld, Peter

AU - Pieters, Rob

PY - 2005/9/1

Y1 - 2005/9/1

N2 - In vitro prednisolone resistance is a poor prognostic factor in the treatment of childhood acute lymphoblastic leukemia (ALL). In a cohort of 54 children with ALL, a lower expression of the glucocorticoid receptor (GR), but not the relative expression levels of the GR-α, GR-β and GR-P isoforms, was associated with in vitro prednisolone resistance.

AB - In vitro prednisolone resistance is a poor prognostic factor in the treatment of childhood acute lymphoblastic leukemia (ALL). In a cohort of 54 children with ALL, a lower expression of the glucocorticoid receptor (GR), but not the relative expression levels of the GR-α, GR-β and GR-P isoforms, was associated with in vitro prednisolone resistance.

KW - Acute lymphoblastic leukemia

KW - Children

KW - Glucocorticoid

KW - Isoforms

KW - Resistance

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M3 - Article

C2 - 16154856

AN - SCOPUS:25444438725

SN - 0390-6078

VL - 90

SP - 1279

EP - 1281

JO - Haematologica

JF - Haematologica

IS - 9

ER -

Expression of the glucocorticoid receptor and its isoforms in relation to glucocorticoid resistance in childhood acute lymphocytic leukemia

Abstract

Keywords

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