Exposure to polybrominated diphenyl ethers and male reproductive function in Greenland, Poland and Ukraine

Gunnar Toft; Virissa Lenters; Roel Vermeulen; Dick Heederik; Cathrine Thomsen; Georg Becher; Aleksander Giwercman; Davide Bizzaro; Gian Carlo Manicardi; Marcello Spanò; Lars Rylander; Henning S. Pedersen; Paweł Struciński; Valentyna Zviezdai; Jens Peter Bonde

doi:10.1016/j.reprotox.2013.10.002

Exposure to polybrominated diphenyl ethers and male reproductive function in Greenland, Poland and Ukraine

Gunnar Toft^*, Virissa Lenters, Roel Vermeulen, Dick Heederik, Cathrine Thomsen, Georg Becher, Aleksander Giwercman, Davide Bizzaro, Gian Carlo Manicardi, Marcello Spanò, Lars Rylander, Henning S. Pedersen, Paweł Struciński, Valentyna Zviezdai, Jens Peter Bonde

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Animal and a few human studies suggest that polybrominated diphenyl ethers (PBDEs) may affect male reproductive function. The aim of the present study was to evaluate if male reproductive function was associated with serum level of PBDEs. We evaluated, in a cross-sectional study, the effects of environmental exposure to BDE-47 and BDE-153 on reproductive hormones and semen quality, including markers of DNA damage and apoptosis, in 299 spouses of pregnant women from Greenland, Poland and Ukraine. Adjusted linear regression models indicated no strong associations between BDE-47 or BDE-153 exposure and markers of male semen quality or reproductive hormones. In the largest study to date we demonstrate that BDE-47 and BDE-153 exposure was not associated with altered semen characteristics or reproductive hormones, indicating that male reproductive function is not affected by the exposure level of these compounds in fertile European or Arctic populations.

Original language	English
Pages (from-to)	1-7
Number of pages	7
Journal	Reproductive Toxicology
Volume	43
DOIs	https://doi.org/10.1016/j.reprotox.2013.10.002
Publication status	Published - Jan 2014
Externally published	Yes

Keywords

Apoptosis
BDE-153
BDE-47
DNA damage
Inhibin B
PBDE
Reproductive hormones
Semen quality

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10.1016/j.reprotox.2013.10.002

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Toft, G., Lenters, V., Vermeulen, R., Heederik, D., Thomsen, C., Becher, G., Giwercman, A., Bizzaro, D., Manicardi, G. C., Spanò, M., Rylander, L., Pedersen, H. S., Struciński, P., Zviezdai, V., & Bonde, J. P. (2014). Exposure to polybrominated diphenyl ethers and male reproductive function in Greenland, Poland and Ukraine. Reproductive Toxicology, 43, 1-7. https://doi.org/10.1016/j.reprotox.2013.10.002

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title = "Exposure to polybrominated diphenyl ethers and male reproductive function in Greenland, Poland and Ukraine",

abstract = "Animal and a few human studies suggest that polybrominated diphenyl ethers (PBDEs) may affect male reproductive function. The aim of the present study was to evaluate if male reproductive function was associated with serum level of PBDEs. We evaluated, in a cross-sectional study, the effects of environmental exposure to BDE-47 and BDE-153 on reproductive hormones and semen quality, including markers of DNA damage and apoptosis, in 299 spouses of pregnant women from Greenland, Poland and Ukraine. Adjusted linear regression models indicated no strong associations between BDE-47 or BDE-153 exposure and markers of male semen quality or reproductive hormones. In the largest study to date we demonstrate that BDE-47 and BDE-153 exposure was not associated with altered semen characteristics or reproductive hormones, indicating that male reproductive function is not affected by the exposure level of these compounds in fertile European or Arctic populations.",

keywords = "Apoptosis, BDE-153, BDE-47, DNA damage, Inhibin B, PBDE, Reproductive hormones, Semen quality",

author = "Gunnar Toft and Virissa Lenters and Roel Vermeulen and Dick Heederik and Cathrine Thomsen and Georg Becher and Aleksander Giwercman and Davide Bizzaro and Manicardi, {Gian Carlo} and Marcello Span{\`o} and Lars Rylander and Pedersen, {Henning S.} and Pawe{\l} Struci{\'n}ski and Valentyna Zviezdai and Bonde, {Jens Peter}",

year = "2014",

month = jan,

doi = "10.1016/j.reprotox.2013.10.002",

language = "English",

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Toft, G, Lenters, V , Vermeulen, R, Heederik, D, Thomsen, C, Becher, G, Giwercman, A, Bizzaro, D, Manicardi, GC, Spanò, M, Rylander, L, Pedersen, HS, Struciński, P, Zviezdai, V & Bonde, JP 2014, 'Exposure to polybrominated diphenyl ethers and male reproductive function in Greenland, Poland and Ukraine', Reproductive Toxicology, vol. 43, pp. 1-7. https://doi.org/10.1016/j.reprotox.2013.10.002

TY - JOUR

T1 - Exposure to polybrominated diphenyl ethers and male reproductive function in Greenland, Poland and Ukraine

AU - Toft, Gunnar

AU - Lenters, Virissa

AU - Vermeulen, Roel

AU - Heederik, Dick

AU - Thomsen, Cathrine

AU - Becher, Georg

AU - Giwercman, Aleksander

AU - Bizzaro, Davide

AU - Manicardi, Gian Carlo

AU - Spanò, Marcello

AU - Rylander, Lars

AU - Pedersen, Henning S.

AU - Struciński, Paweł

AU - Zviezdai, Valentyna

AU - Bonde, Jens Peter

PY - 2014/1

Y1 - 2014/1

N2 - Animal and a few human studies suggest that polybrominated diphenyl ethers (PBDEs) may affect male reproductive function. The aim of the present study was to evaluate if male reproductive function was associated with serum level of PBDEs. We evaluated, in a cross-sectional study, the effects of environmental exposure to BDE-47 and BDE-153 on reproductive hormones and semen quality, including markers of DNA damage and apoptosis, in 299 spouses of pregnant women from Greenland, Poland and Ukraine. Adjusted linear regression models indicated no strong associations between BDE-47 or BDE-153 exposure and markers of male semen quality or reproductive hormones. In the largest study to date we demonstrate that BDE-47 and BDE-153 exposure was not associated with altered semen characteristics or reproductive hormones, indicating that male reproductive function is not affected by the exposure level of these compounds in fertile European or Arctic populations.

AB - Animal and a few human studies suggest that polybrominated diphenyl ethers (PBDEs) may affect male reproductive function. The aim of the present study was to evaluate if male reproductive function was associated with serum level of PBDEs. We evaluated, in a cross-sectional study, the effects of environmental exposure to BDE-47 and BDE-153 on reproductive hormones and semen quality, including markers of DNA damage and apoptosis, in 299 spouses of pregnant women from Greenland, Poland and Ukraine. Adjusted linear regression models indicated no strong associations between BDE-47 or BDE-153 exposure and markers of male semen quality or reproductive hormones. In the largest study to date we demonstrate that BDE-47 and BDE-153 exposure was not associated with altered semen characteristics or reproductive hormones, indicating that male reproductive function is not affected by the exposure level of these compounds in fertile European or Arctic populations.

KW - Apoptosis

KW - BDE-153

KW - BDE-47

KW - DNA damage

KW - Inhibin B

KW - PBDE

KW - Reproductive hormones

KW - Semen quality

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U2 - 10.1016/j.reprotox.2013.10.002

DO - 10.1016/j.reprotox.2013.10.002

M3 - Article

C2 - 24513925

AN - SCOPUS:84887514890

SN - 0890-6238

VL - 43

SP - 1

EP - 7

JO - Reproductive Toxicology

JF - Reproductive Toxicology

ER -

Exposure to polybrominated diphenyl ethers and male reproductive function in Greenland, Poland and Ukraine

Abstract

Keywords

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