Exposure to Night-Time Traffic Noise, Melatonin-Regulating Gene Variants and Change in Glycemia in Adults

I. C. Eze; M. Imboden; M. Foraster; E. Schaffner; A. Kumar; D. Vienneau; H. Heritier; F. Rudzik; L. Thiesse; R. Pieren; A. von Eckardstein; C. Schindler; M. Brink; J. M. Wunderli; C. Cajochen; M. Roosli; N. Probst-Hensch

doi:10.3390/ijerph14121492

Exposure to Night-Time Traffic Noise, Melatonin-Regulating Gene Variants and Change in Glycemia in Adults

I. C. Eze, M. Imboden, M. Foraster, E. Schaffner, A. Kumar, D. Vienneau, H. Heritier, F. Rudzik, L. Thiesse, R. Pieren, A. von Eckardstein, C. Schindler, M. Brink, J. M. Wunderli, C. Cajochen, M. Roosli, N. Probst-Hensch

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Traffic noise has been linked to diabetes, with limited understanding of its mechanisms. We hypothesize that night-time road traffic noise (RTN) may impair glucose homeostasis through circadian rhythm disturbances. We prospectively investigated the relationship between residential night-time RTN and subsequent eight-year change in glycosylated hemoglobin (ΔHbA1c) in 3350 participants of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA), adjusting for diabetes risk factors and air pollution levels. Annual average RTN (Lnight) was assigned to participants in 2001 using validated Swiss noise models. HbA1c was measured in 2002 and 2011 using liquid chromatography. We applied mixed linear models to explore RTN–ΔHbA1c association and its modification by a genetic risk score of six common circadian-related MTNR1B variants (MGRS). A 10 dB difference in RTN was associated with a 0.02% (0.003–0.04%) increase in mean DHbA1c in 2142 non-movers. RTN–ΔHbA_1c association was modified by MGRS among diabetic participants (P_interaction = 0.001). A similar trend in non-diabetic participants was non-significant. Among the single variants, we observed strongest interactions with rs10830963, an acknowledged diabetes risk variant also implicated in melatonin profile dysregulation. Night-time RTN may impair glycemic control, especially in diabetic individuals, through circadian rhythm disturbances. Experimental sleep studies are needed to test whether noise control may help individuals to attain optimal glycemic levels.

Original language	English
Article number	1492
Journal	International journal of environmental research and public health
Volume	14
Issue number	12
DOIs	https://doi.org/10.3390/ijerph14121492
Publication status	Published - 2017
Externally published	Yes

Keywords

Adult Aged Aged, 80 and over *Blood Glucose Cohort Studies Environmental Exposure/*adverse effects Female Genetic Variation Glycated Hemoglobin A/*analysis Housing Humans Linear Models Male Melatonin/metabolism Middle Aged Noise, Transportation/*adverse effects Receptor, Melatonin, MT1/genetics Risk Factors Sleep Switzerland *MTNR1B gene *adults *circadian sleep-wake cycle *cohort study *diabetes *gene-environment interactions *glycosylated hemoglobin *rs10830963 *transportation noise the design of the study in the collection, analyses, or interpretation of data in the writing of the manuscript, and in the decision to publish the results.

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10.3390/ijerph14121492Licence: CC BY

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Eze, I. C., Imboden, M., Foraster, M., Schaffner, E., Kumar, A., Vienneau, D., Heritier, H., Rudzik, F., Thiesse, L., Pieren, R., von Eckardstein, A., Schindler, C., Brink, M., Wunderli, J. M., Cajochen, C., Roosli, M., & Probst-Hensch, N. (2017). Exposure to Night-Time Traffic Noise, Melatonin-Regulating Gene Variants and Change in Glycemia in Adults. International journal of environmental research and public health, 14(12), Article 1492. https://doi.org/10.3390/ijerph14121492

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abstract = "Traffic noise has been linked to diabetes, with limited understanding of its mechanisms. We hypothesize that night-time road traffic noise (RTN) may impair glucose homeostasis through circadian rhythm disturbances. We prospectively investigated the relationship between residential night-time RTN and subsequent eight-year change in glycosylated hemoglobin (ΔHbA1c) in 3350 participants of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA), adjusting for diabetes risk factors and air pollution levels. Annual average RTN (Lnight) was assigned to participants in 2001 using validated Swiss noise models. HbA1c was measured in 2002 and 2011 using liquid chromatography. We applied mixed linear models to explore RTN–ΔHbA1c association and its modification by a genetic risk score of six common circadian-related MTNR1B variants (MGRS). A 10 dB difference in RTN was associated with a 0.02% (0.003–0.04%) increase in mean DHbA1c in 2142 non-movers. RTN–ΔHbA1c association was modified by MGRS among diabetic participants (Pinteraction = 0.001). A similar trend in non-diabetic participants was non-significant. Among the single variants, we observed strongest interactions with rs10830963, an acknowledged diabetes risk variant also implicated in melatonin profile dysregulation. Night-time RTN may impair glycemic control, especially in diabetic individuals, through circadian rhythm disturbances. Experimental sleep studies are needed to test whether noise control may help individuals to attain optimal glycemic levels.",

keywords = "Adult Aged Aged, 80 and over *Blood Glucose Cohort Studies Environmental Exposure/*adverse effects Female Genetic Variation Glycated Hemoglobin A/*analysis Housing Humans Linear Models Male Melatonin/metabolism Middle Aged Noise, Transportation/*adverse effects Receptor, Melatonin, MT1/genetics Risk Factors Sleep Switzerland *MTNR1B gene *adults *circadian sleep-wake cycle *cohort study *diabetes *gene-environment interactions *glycosylated hemoglobin *rs10830963 *transportation noise the design of the study in the collection, analyses, or interpretation of data in the writing of the manuscript, and in the decision to publish the results.",

author = "Eze, {I. C.} and M. Imboden and M. Foraster and E. Schaffner and A. Kumar and D. Vienneau and H. Heritier and F. Rudzik and L. Thiesse and R. Pieren and {von Eckardstein}, A. and C. Schindler and M. Brink and Wunderli, {J. M.} and C. Cajochen and M. Roosli and N. Probst-Hensch",

note = "Publisher Copyright: {\textcopyright} 2017 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2017",

doi = "10.3390/ijerph14121492",

language = "English",

volume = "14",

journal = "International journal of environmental research and public health",

issn = "1660-4601",

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Eze, IC, Imboden, M, Foraster, M, Schaffner, E, Kumar, A, Vienneau, D, Heritier, H, Rudzik, F, Thiesse, L, Pieren, R, von Eckardstein, A, Schindler, C, Brink, M, Wunderli, JM, Cajochen, C, Roosli, M & Probst-Hensch, N 2017, 'Exposure to Night-Time Traffic Noise, Melatonin-Regulating Gene Variants and Change in Glycemia in Adults', International journal of environmental research and public health, vol. 14, no. 12, 1492. https://doi.org/10.3390/ijerph14121492

TY - JOUR

T1 - Exposure to Night-Time Traffic Noise, Melatonin-Regulating Gene Variants and Change in Glycemia in Adults

AU - Eze, I. C.

AU - Imboden, M.

AU - Foraster, M.

AU - Schaffner, E.

AU - Kumar, A.

AU - Vienneau, D.

AU - Heritier, H.

AU - Rudzik, F.

AU - Thiesse, L.

AU - Pieren, R.

AU - von Eckardstein, A.

AU - Schindler, C.

AU - Brink, M.

AU - Wunderli, J. M.

AU - Cajochen, C.

AU - Roosli, M.

AU - Probst-Hensch, N.

PY - 2017

Y1 - 2017

N2 - Traffic noise has been linked to diabetes, with limited understanding of its mechanisms. We hypothesize that night-time road traffic noise (RTN) may impair glucose homeostasis through circadian rhythm disturbances. We prospectively investigated the relationship between residential night-time RTN and subsequent eight-year change in glycosylated hemoglobin (ΔHbA1c) in 3350 participants of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA), adjusting for diabetes risk factors and air pollution levels. Annual average RTN (Lnight) was assigned to participants in 2001 using validated Swiss noise models. HbA1c was measured in 2002 and 2011 using liquid chromatography. We applied mixed linear models to explore RTN–ΔHbA1c association and its modification by a genetic risk score of six common circadian-related MTNR1B variants (MGRS). A 10 dB difference in RTN was associated with a 0.02% (0.003–0.04%) increase in mean DHbA1c in 2142 non-movers. RTN–ΔHbA1c association was modified by MGRS among diabetic participants (Pinteraction = 0.001). A similar trend in non-diabetic participants was non-significant. Among the single variants, we observed strongest interactions with rs10830963, an acknowledged diabetes risk variant also implicated in melatonin profile dysregulation. Night-time RTN may impair glycemic control, especially in diabetic individuals, through circadian rhythm disturbances. Experimental sleep studies are needed to test whether noise control may help individuals to attain optimal glycemic levels.

AB - Traffic noise has been linked to diabetes, with limited understanding of its mechanisms. We hypothesize that night-time road traffic noise (RTN) may impair glucose homeostasis through circadian rhythm disturbances. We prospectively investigated the relationship between residential night-time RTN and subsequent eight-year change in glycosylated hemoglobin (ΔHbA1c) in 3350 participants of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA), adjusting for diabetes risk factors and air pollution levels. Annual average RTN (Lnight) was assigned to participants in 2001 using validated Swiss noise models. HbA1c was measured in 2002 and 2011 using liquid chromatography. We applied mixed linear models to explore RTN–ΔHbA1c association and its modification by a genetic risk score of six common circadian-related MTNR1B variants (MGRS). A 10 dB difference in RTN was associated with a 0.02% (0.003–0.04%) increase in mean DHbA1c in 2142 non-movers. RTN–ΔHbA1c association was modified by MGRS among diabetic participants (Pinteraction = 0.001). A similar trend in non-diabetic participants was non-significant. Among the single variants, we observed strongest interactions with rs10830963, an acknowledged diabetes risk variant also implicated in melatonin profile dysregulation. Night-time RTN may impair glycemic control, especially in diabetic individuals, through circadian rhythm disturbances. Experimental sleep studies are needed to test whether noise control may help individuals to attain optimal glycemic levels.

KW - Adult Aged Aged, 80 and over Blood Glucose Cohort Studies Environmental Exposure/adverse effects Female Genetic Variation Glycated Hemoglobin A/analysis Housing Humans Linear Models Male Melatonin/metabolism Middle Aged Noise, Transportation/adverse effec

U2 - 10.3390/ijerph14121492

DO - 10.3390/ijerph14121492

M3 - Article

SN - 1660-4601

VL - 14

JO - International journal of environmental research and public health

JF - International journal of environmental research and public health

IS - 12

M1 - 1492

ER -

Exposure to Night-Time Traffic Noise, Melatonin-Regulating Gene Variants and Change in Glycemia in Adults

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