TY - JOUR
T1 - Exploring interdisciplinary perspectives on the implementation of personalized medicine and patient-orchestrated care in Alzheimer's disease
T2 - A qualitative study within the ABOARD research project.
AU - de Rijke, Tanja J
AU - Vasseur, Dianne
AU - van der Flier, Wiesje M
AU - Minkman, Mirella Mn
AU - Rhodius-Meester, Hanneke Fm
AU - Verwey, Nicolaas A
AU - Smets, Ellen Ma
AU - Visser, Leonie Nc
N1 - Publisher Copyright:
© The Author(s) 2025.
PY - 2025/5
Y1 - 2025/5
N2 - BackgroundThe concepts of '
personalized medicine' and '
patient-orchestrated care' in Alzheimer's disease (AD) lack standard conceptualization, which presents challenges for collaborative and interdisciplinary care.ObjectiveWe explored the interpretations and perspectives of professionals involved in interdisciplinary work on a large-scale project, "ABOARD", with the aim to implement
personalized medicine and
patient-orchestrated care in AD.MethodsSemi-structured interviews were conducted with 30 professionals and audio-recorded. Two researchers independently coded the data inductively, followed by a thematic analysis.ResultsAccording to professionals across different disciplinary backgrounds (mean age 45.7 years; 53.3% female),
personalized medicine pertains to the relevant options that an individual has, informed by biomedical and psychosocial factors, whereas
patient-orchestrated care captures factors relevant to the decision-making process. Professionals differed in their views on
patient-orchestrated care regarding its desirability and feasibility. The concepts were viewed as similar by professionals, as both involve personal preferences while ultimately assigning responsibility to the clinician. However, implementation challenges persist, and no thematic differences were found between clinicians and other AD-related professionals.ConclusionsAD professionals have shared interpretations and perspectives on implementation of
personalized medicine but differed in their views on patient-orchestrated care. Personal preferences are seen as part of
personalized medicine, but not yet reflected in definitions in the AD field and beyond. Critical discussions on the challenges and existing doubts are necessary for both
personalized medicine and
patient-orchestrated care. Multi-level implementation changes are needed for both concepts, which warrants stakeholder involvement as well as support and resources from the entire AD field.
AB - BackgroundThe concepts of '
personalized medicine' and '
patient-orchestrated care' in Alzheimer's disease (AD) lack standard conceptualization, which presents challenges for collaborative and interdisciplinary care.ObjectiveWe explored the interpretations and perspectives of professionals involved in interdisciplinary work on a large-scale project, "ABOARD", with the aim to implement
personalized medicine and
patient-orchestrated care in AD.MethodsSemi-structured interviews were conducted with 30 professionals and audio-recorded. Two researchers independently coded the data inductively, followed by a thematic analysis.ResultsAccording to professionals across different disciplinary backgrounds (mean age 45.7 years; 53.3% female),
personalized medicine pertains to the relevant options that an individual has, informed by biomedical and psychosocial factors, whereas
patient-orchestrated care captures factors relevant to the decision-making process. Professionals differed in their views on
patient-orchestrated care regarding its desirability and feasibility. The concepts were viewed as similar by professionals, as both involve personal preferences while ultimately assigning responsibility to the clinician. However, implementation challenges persist, and no thematic differences were found between clinicians and other AD-related professionals.ConclusionsAD professionals have shared interpretations and perspectives on implementation of
personalized medicine but differed in their views on patient-orchestrated care. Personal preferences are seen as part of
personalized medicine, but not yet reflected in definitions in the AD field and beyond. Critical discussions on the challenges and existing doubts are necessary for both
personalized medicine and
patient-orchestrated care. Multi-level implementation changes are needed for both concepts, which warrants stakeholder involvement as well as support and resources from the entire AD field.
U2 - 10.1177/13872877251326166
DO - 10.1177/13872877251326166
M3 - Article
C2 - 40116704
SN - 1387-2877
VL - 105
SP - 120
EP - 133
JO - Journal of Alzheimer's disease : JAD
JF - Journal of Alzheimer's disease : JAD
IS - 1
ER -