TY - JOUR
T1 - Experimental study of the detrimental effect of dopamine/glucagon combination in d,I-propranolol intoxication
AU - Toet, A. E.
AU - Werner, J.
AU - Vleeming, W.
AU - Te Biesebeek, J. D.
AU - Meulenbelt, J.
AU - De Wildt, D. J.
PY - 1996/12/1
Y1 - 1996/12/1
N2 - 1 Respiratory and cardiovascular failure are the principle toxic effects of β-blocker overdose. Respiratory arrest is the primary cause of death in β-blocker intoxicated rats. 2 The effect of glucagon, dopamine and the combination of giucagon/dopamine on respiratory and cardiovascular function and survival time in β-blocker overdose was investigated in a model of acute d,I-propranolol (resp. 30 and 15 mg kg-1 h-1 in rat and rabbit) intoxication in spontaneously breathing rats and artifically ventilated rats and rabbits. 3 Glucagon (initial dose of 100 μg kg-1 (bolus), followed by 1 μg kg-1 min-1), dopamine (25 μg kg-1 min-1) or the combination of gfucagon/dopamine did not improve survival time (ST) in d,I-propranolol intoxicated spontaneously breathing rats and artificially ventilated rats and rabbits, although some haemodynamic variables i.e. heart rate (HR), mean arterial blood pressure (MAP), left ventricular pressure (LVPmax) and the differentiated left ventricular pressure (LVdp/dtmax) temporarily improved. 4 Survival time was considerably reduced in d,I-propranolol intoxicated spontaneously breathing and artifically ventilated rats treated with a combination of glucagon/dopamine, which induced a decrease in PaO2 and pH and an increase in PaCO2 partly due to ventilation/perfusion mismatch. 5 The combination of glucagon/dopamine should be used carefully in the treatment of β-blocker overdose in man.
AB - 1 Respiratory and cardiovascular failure are the principle toxic effects of β-blocker overdose. Respiratory arrest is the primary cause of death in β-blocker intoxicated rats. 2 The effect of glucagon, dopamine and the combination of giucagon/dopamine on respiratory and cardiovascular function and survival time in β-blocker overdose was investigated in a model of acute d,I-propranolol (resp. 30 and 15 mg kg-1 h-1 in rat and rabbit) intoxication in spontaneously breathing rats and artifically ventilated rats and rabbits. 3 Glucagon (initial dose of 100 μg kg-1 (bolus), followed by 1 μg kg-1 min-1), dopamine (25 μg kg-1 min-1) or the combination of gfucagon/dopamine did not improve survival time (ST) in d,I-propranolol intoxicated spontaneously breathing rats and artificially ventilated rats and rabbits, although some haemodynamic variables i.e. heart rate (HR), mean arterial blood pressure (MAP), left ventricular pressure (LVPmax) and the differentiated left ventricular pressure (LVdp/dtmax) temporarily improved. 4 Survival time was considerably reduced in d,I-propranolol intoxicated spontaneously breathing and artifically ventilated rats treated with a combination of glucagon/dopamine, which induced a decrease in PaO2 and pH and an increase in PaCO2 partly due to ventilation/perfusion mismatch. 5 The combination of glucagon/dopamine should be used carefully in the treatment of β-blocker overdose in man.
KW - Cardiovascular function
KW - Dopamine
KW - Glucagon
KW - Propranolol intoxication
KW - Respiratory function
KW - Survival
UR - https://www.scopus.com/pages/publications/0029944032
M3 - Article
C2 - 8735466
AN - SCOPUS:0029944032
SN - 0960-3271
VL - 15
SP - 411
EP - 421
JO - Human & Experimental Toxicology
JF - Human & Experimental Toxicology
IS - 5
ER -