Exosomen en kanker

Translated title of the contribution: Exosomes and cancer

Jeroen de Vrij, S L Niek Maas, Joost P Hegmans, Martine L Lamfers, Clemens M F Dirven, Marike L D Broekman

Research output: Contribution to journalReview articlepeer-review


Exosomes are a subtype of vesicles released by cells of both healthy and neoplastic origin. Preclinical studies suggest a role for tumour-derived exosomes in tumour progression, mainly through the transfer of RNA and proteins from tumour cells to other cells. The transfer of RNA and proteins by tumour-derived exosomes seems to mediate stimulation of angiogenesis and suppression of immune cells; in contrast, exosomes from healthy cells of the immune system appear to have anti-tumour characteristics. Characterisation of the RNA or protein profile of tumour-derived exosomes could have diagnostic or prognostic value, for example, in brain tumours. Anti-tumour therapies could be based on exosomes, for example, by blocking the formation of tumour-derived exosomes or having exosomes release therapeutic agents at specific sites. The most advanced application of this is the use of exosomes from dendritic cells in tumour vaccination; the safety of this has been demonstrated in phase I studies.

Translated title of the contributionExosomes and cancer
Original languageDutch
Pages (from-to)A3677
JournalNederlands Tijdschrift voor Geneeskunde
Issue number51
Publication statusPublished - 2011


  • Antigens, Neoplasm/immunology
  • Cancer Vaccines/immunology
  • Dendritic Cells/immunology
  • Exosomes/immunology
  • Humans
  • Neoplasm Proteins/isolation & purification
  • Neoplasms/immunology
  • Signal Transduction


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