Executive summary of the 12th HHT international scientific conference

Jillian W. Andrejecsk; Anna E. Hosman; Luisa M. Botella; Claire L. Shovlin; Helen M. Arthur; Sophie Dupuis-Girod; Elisabetta Buscarini; Christopher C.W. Hughes; Franck Lebrin; Christine L. Mummery; Marco C. Post; Johannes J. Mager

doi:10.1007/s10456-017-9585-2

Executive summary of the 12th HHT international scientific conference

Jillian W. Andrejecsk
, Anna E. Hosman
, Luisa M. Botella
, Claire L. Shovlin
, Helen M. Arthur
, Sophie Dupuis-Girod
, Elisabetta Buscarini
, Christopher C.W. Hughes
, Franck Lebrin^*
, Christine L. Mummery
, Marco C. Post
, Johannes J. Mager

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Hereditary hemorrhagic telangiectasia is an autosomal dominant trait affecting approximately 1 in 5000 people. A pathogenic DNA sequence variant in the ENG, ACVRL1 or SMAD4 genes, can be found in the majority of patients. The 12th International Scientific HHT Conference was held on June 8–11, 2017 in Dubrovnik, Croatia to present and discuss the latest scientific achievements, and was attended by over 200 scientific and clinical researchers. In total 174 abstracts were accepted of which 58 were selected for oral presentations. This article covers the basic science and clinical talks, and discussions from three theme-based workshops. We focus on significant emergent themes and unanswered questions. Understanding these topics and answering these questions will help to define the future of HHT research and therapeutics, and ultimately bring us closer to a cure.

Original language	English
Pages (from-to)	169-181
Number of pages	13
Journal	Angiogenesis
Volume	21
Issue number	1
DOIs	https://doi.org/10.1007/s10456-017-9585-2
Publication status	Published - 1 Feb 2018
Externally published	Yes

Keywords

Activin receptor-like kinase 1 (ALK1)
Arteriovenous malformation
Endoglin
Epistaxis
Hereditary hemorrhagic telangiectasia
HHT

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title = "Executive summary of the 12th HHT international scientific conference",

abstract = "Hereditary hemorrhagic telangiectasia is an autosomal dominant trait affecting approximately 1 in 5000 people. A pathogenic DNA sequence variant in the ENG, ACVRL1 or SMAD4 genes, can be found in the majority of patients. The 12th International Scientific HHT Conference was held on June 8{\textendash}11, 2017 in Dubrovnik, Croatia to present and discuss the latest scientific achievements, and was attended by over 200 scientific and clinical researchers. In total 174 abstracts were accepted of which 58 were selected for oral presentations. This article covers the basic science and clinical talks, and discussions from three theme-based workshops. We focus on significant emergent themes and unanswered questions. Understanding these topics and answering these questions will help to define the future of HHT research and therapeutics, and ultimately bring us closer to a cure.",

keywords = "Activin receptor-like kinase 1 (ALK1), Arteriovenous malformation, Endoglin, Epistaxis, Hereditary hemorrhagic telangiectasia, HHT",

author = "Andrejecsk, \{Jillian W.\} and Hosman, \{Anna E.\} and Botella, \{Luisa M.\} and Shovlin, \{Claire L.\} and Arthur, \{Helen M.\} and Sophie Dupuis-Girod and Elisabetta Buscarini and Hughes, \{Christopher C.W.\} and Franck Lebrin and Mummery, \{Christine L.\} and Post, \{Marco C.\} and Mager, \{Johannes J.\}",

note = "Publisher Copyright: {\textcopyright} 2017, Springer Science+Business Media B.V., part of Springer Nature.",

year = "2018",

month = feb,

day = "1",

doi = "10.1007/s10456-017-9585-2",

language = "English",

volume = "21",

pages = "169--181",

journal = "Angiogenesis",

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AU - Andrejecsk, Jillian W.

AU - Hosman, Anna E.

AU - Botella, Luisa M.

AU - Shovlin, Claire L.

AU - Arthur, Helen M.

AU - Dupuis-Girod, Sophie

AU - Buscarini, Elisabetta

AU - Hughes, Christopher C.W.

AU - Lebrin, Franck

AU - Mummery, Christine L.

AU - Post, Marco C.

AU - Mager, Johannes J.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Hereditary hemorrhagic telangiectasia is an autosomal dominant trait affecting approximately 1 in 5000 people. A pathogenic DNA sequence variant in the ENG, ACVRL1 or SMAD4 genes, can be found in the majority of patients. The 12th International Scientific HHT Conference was held on June 8–11, 2017 in Dubrovnik, Croatia to present and discuss the latest scientific achievements, and was attended by over 200 scientific and clinical researchers. In total 174 abstracts were accepted of which 58 were selected for oral presentations. This article covers the basic science and clinical talks, and discussions from three theme-based workshops. We focus on significant emergent themes and unanswered questions. Understanding these topics and answering these questions will help to define the future of HHT research and therapeutics, and ultimately bring us closer to a cure.

AB - Hereditary hemorrhagic telangiectasia is an autosomal dominant trait affecting approximately 1 in 5000 people. A pathogenic DNA sequence variant in the ENG, ACVRL1 or SMAD4 genes, can be found in the majority of patients. The 12th International Scientific HHT Conference was held on June 8–11, 2017 in Dubrovnik, Croatia to present and discuss the latest scientific achievements, and was attended by over 200 scientific and clinical researchers. In total 174 abstracts were accepted of which 58 were selected for oral presentations. This article covers the basic science and clinical talks, and discussions from three theme-based workshops. We focus on significant emergent themes and unanswered questions. Understanding these topics and answering these questions will help to define the future of HHT research and therapeutics, and ultimately bring us closer to a cure.

KW - Activin receptor-like kinase 1 (ALK1)

KW - Arteriovenous malformation

KW - Endoglin

KW - Epistaxis

KW - Hereditary hemorrhagic telangiectasia

KW - HHT

UR - https://www.scopus.com/pages/publications/85042237834

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DO - 10.1007/s10456-017-9585-2

M3 - Article

AN - SCOPUS:85042237834

SN - 0969-6970

VL - 21

SP - 169

EP - 181

JO - Angiogenesis

JF - Angiogenesis

IS - 1

ER -

Executive summary of the 12th HHT international scientific conference

Abstract

Keywords

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