Evolutionary implications of SARS-CoV-2 vaccination for the future design of vaccination strategies

Igor M Rouzine; Ganna Rozhnova

doi:10.1038/s43856-023-00320-x

Evolutionary implications of SARS-CoV-2 vaccination for the future design of vaccination strategies

Igor M Rouzine^*, Ganna Rozhnova^*

^*Corresponding author for this work

Julius Center, dept. Epidemiology & Health Economics

Research output: Contribution to journal › Review article › peer-review

3 Downloads (Pure)

Abstract

Once the first SARS-CoV-2 vaccine became available, mass vaccination was the main pillar of the public health response to the COVID-19 pandemic. It was very effective in reducing hospitalizations and deaths. Here, we discuss the possibility that mass vaccination might accelerate SARS-CoV-2 evolution in antibody-binding regions compared to natural infection at the population level. Using the evidence of strong genetic variation in antibody-binding regions and taking advantage of the similarity between the envelope proteins of SARS-CoV-2 and influenza, we assume that immune selection pressure acting on these regions of the two viruses is similar. We discuss the consequences of this assumption for SARS-CoV-2 evolution in light of mathematical models developed previously for influenza. We further outline the implications of this phenomenon, if our assumptions are confirmed, for the future design of SARS-CoV-2 vaccination strategies.

Original language	English
Article number	86
Number of pages	14
Journal	Communications medicine
Volume	3
Issue number	1
DOIs	https://doi.org/10.1038/s43856-023-00320-x
Publication status	Published - 19 Jun 2023

Access to Document

10.1038/s43856-023-00320-xLicence: CC BY

s43856-023-00320-xFinal published version, 1.12 MBLicence: CC BY

Cite this

@article{c5cff3dbf8a04ad097c740a82899c15d,

title = "Evolutionary implications of SARS-CoV-2 vaccination for the future design of vaccination strategies",

abstract = "Once the first SARS-CoV-2 vaccine became available, mass vaccination was the main pillar of the public health response to the COVID-19 pandemic. It was very effective in reducing hospitalizations and deaths. Here, we discuss the possibility that mass vaccination might accelerate SARS-CoV-2 evolution in antibody-binding regions compared to natural infection at the population level. Using the evidence of strong genetic variation in antibody-binding regions and taking advantage of the similarity between the envelope proteins of SARS-CoV-2 and influenza, we assume that immune selection pressure acting on these regions of the two viruses is similar. We discuss the consequences of this assumption for SARS-CoV-2 evolution in light of mathematical models developed previously for influenza. We further outline the implications of this phenomenon, if our assumptions are confirmed, for the future design of SARS-CoV-2 vaccination strategies.",

author = "Rouzine, {Igor M} and Ganna Rozhnova",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2023.",

year = "2023",

month = jun,

day = "19",

doi = "10.1038/s43856-023-00320-x",

language = "English",

volume = "3",

number = "1",

}

TY - JOUR

T1 - Evolutionary implications of SARS-CoV-2 vaccination for the future design of vaccination strategies

AU - Rouzine, Igor M

AU - Rozhnova, Ganna

PY - 2023/6/19

Y1 - 2023/6/19

N2 - Once the first SARS-CoV-2 vaccine became available, mass vaccination was the main pillar of the public health response to the COVID-19 pandemic. It was very effective in reducing hospitalizations and deaths. Here, we discuss the possibility that mass vaccination might accelerate SARS-CoV-2 evolution in antibody-binding regions compared to natural infection at the population level. Using the evidence of strong genetic variation in antibody-binding regions and taking advantage of the similarity between the envelope proteins of SARS-CoV-2 and influenza, we assume that immune selection pressure acting on these regions of the two viruses is similar. We discuss the consequences of this assumption for SARS-CoV-2 evolution in light of mathematical models developed previously for influenza. We further outline the implications of this phenomenon, if our assumptions are confirmed, for the future design of SARS-CoV-2 vaccination strategies.

AB - Once the first SARS-CoV-2 vaccine became available, mass vaccination was the main pillar of the public health response to the COVID-19 pandemic. It was very effective in reducing hospitalizations and deaths. Here, we discuss the possibility that mass vaccination might accelerate SARS-CoV-2 evolution in antibody-binding regions compared to natural infection at the population level. Using the evidence of strong genetic variation in antibody-binding regions and taking advantage of the similarity between the envelope proteins of SARS-CoV-2 and influenza, we assume that immune selection pressure acting on these regions of the two viruses is similar. We discuss the consequences of this assumption for SARS-CoV-2 evolution in light of mathematical models developed previously for influenza. We further outline the implications of this phenomenon, if our assumptions are confirmed, for the future design of SARS-CoV-2 vaccination strategies.

U2 - 10.1038/s43856-023-00320-x

DO - 10.1038/s43856-023-00320-x

M3 - Review article

C2 - 37336956

SN - 2730-664X

VL - 3

JO - Communications medicine

JF - Communications medicine

IS - 1

M1 - 86

ER -

Evolutionary implications of SARS-CoV-2 vaccination for the future design of vaccination strategies

Abstract

Access to Document

Fingerprint

Cite this