TY - JOUR
T1 - Evolution of cerebral microbleeds after cranial irradiation in medulloblastoma patients
AU - Roongpiboonsopit, Duangnapa
AU - Kuijf, Hugo J.
AU - Charidimou, Andreas
AU - Xiong, Li
AU - Vashkevich, Anastasia
AU - Martinez-Ramirez, Sergi
AU - Shih, Helen A.
AU - Gill, Corey M.
AU - Viswanathan, Anand
AU - Dietrich, Jorg
PY - 2017/2/21
Y1 - 2017/2/21
N2 - Objective: To characterize the temporal and spatial pattern of cerebral microbleeds (CMBs) after cranial irradiation in patients with medulloblastoma. Methods: We retrospectively identified patients with medulloblastoma treated with craniospinal irradiation at the Massachusetts General Hospital between 1999 and 2015. Longitudinal MRI including T2-weighted gradient-recalled echo (GRE) sequences were reviewed, and the prevalence, spatial pattern, and risk factors associated with CMBs were characterized. Results: We identified a total of 27 patients; 5 patients were children (median age 6.3 years) and 22 patients were adults (median age 28.8 years). CMBs were found in 67% (18/27) of patients, who were followed for a median of 4.1 years. Patients with CMBs had longer GRE follow-up time compared to those without CMBs (4.9 vs 1.7 years, p = 0.035). The median latency of the appearance of CMBs was 2.79 years (interquartile range 1.76-4.26). The prevalence of CMBs increased with each year from time of radiation therapy, and the cumulative prevalence was highest in patients age
AB - Objective: To characterize the temporal and spatial pattern of cerebral microbleeds (CMBs) after cranial irradiation in patients with medulloblastoma. Methods: We retrospectively identified patients with medulloblastoma treated with craniospinal irradiation at the Massachusetts General Hospital between 1999 and 2015. Longitudinal MRI including T2-weighted gradient-recalled echo (GRE) sequences were reviewed, and the prevalence, spatial pattern, and risk factors associated with CMBs were characterized. Results: We identified a total of 27 patients; 5 patients were children (median age 6.3 years) and 22 patients were adults (median age 28.8 years). CMBs were found in 67% (18/27) of patients, who were followed for a median of 4.1 years. Patients with CMBs had longer GRE follow-up time compared to those without CMBs (4.9 vs 1.7 years, p = 0.035). The median latency of the appearance of CMBs was 2.79 years (interquartile range 1.76-4.26). The prevalence of CMBs increased with each year from time of radiation therapy, and the cumulative prevalence was highest in patients age
UR - http://www.scopus.com/inward/record.url?scp=85013393522&partnerID=8YFLogxK
U2 - 10.1212/WNL.0000000000003631
DO - 10.1212/WNL.0000000000003631
M3 - Article
C2 - 28122904
AN - SCOPUS:85013393522
SN - 0028-3878
VL - 88
SP - 789
EP - 796
JO - Neurology
JF - Neurology
IS - 8
ER -