Evidence for tetracycline resistance determinant tet(M) allele replacement in a Streptococcus pneumoniae population of limited geographical origin

Katarzyna Dzieranowska-Fangrat; Katarzyna Semczuk; Paulina Górska; Stefania Giedrys-Kalemba; Maria Kochman; Alfred Samet; Stefan Tyski; Danuta Dzieranowska; Krzysztof Trzciński

doi:10.1016/j.ijantimicag.2005.10.003

Evidence for tetracycline resistance determinant tet(M) allele replacement in a Streptococcus pneumoniae population of limited geographical origin

Katarzyna Dzieranowska-Fangrat
, Katarzyna Semczuk
, Paulina Górska
, Stefania Giedrys-Kalemba
, Maria Kochman
, Alfred Samet
, Stefan Tyski
, Danuta Dzieranowska
, Krzysztof Trzciński^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

8 Citations (Scopus)

Abstract

A collection of 185 Streptococcus pneumoniae isolates was tested for their susceptibility to antipneumococcal drugs, with a focus on the distribution of tetracycline resistance determinants tet(M) and tet(O). Resistance patterns were compared with established correlates of multidrug resistance, and tetracycline-resistant isolates were tested for clonality and allelic variation within tet(M). Resistance to tetracyclines, penicillins and macrolides were all strongly related to multidrug resistance. Over one-quarter of the strains were tetracycline resistant, all via the tet(M)-mediated mechanism. Restriction fragment length polymorphism analysis revealed a high degree of allelic variation within tet(M) and gave evidence of a clonal and horizontal spread of selected alleles. A tet(M) variant that emerged with the onset of epidemic multidrug-resistant strains was replacing old alleles in the population.

Original language	English
Pages (from-to)	159-164
Number of pages	6
Journal	International Journal of Antimicrobial Agents
Volume	27
Issue number	2
DOIs	https://doi.org/10.1016/j.ijantimicag.2005.10.003
Publication status	Published - 1 Feb 2006

Keywords

Streptococcus pneumoniae
tet(M)
Tetracycline

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10.1016/j.ijantimicag.2005.10.003

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Dzieranowska-Fangrat, K., Semczuk, K., Górska, P., Giedrys-Kalemba, S., Kochman, M., Samet, A., Tyski, S., Dzieranowska, D., & Trzciński, K. (2006). Evidence for tetracycline resistance determinant tet(M) allele replacement in a Streptococcus pneumoniae population of limited geographical origin. International Journal of Antimicrobial Agents, 27(2), 159-164. https://doi.org/10.1016/j.ijantimicag.2005.10.003

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title = "Evidence for tetracycline resistance determinant tet(M) allele replacement in a Streptococcus pneumoniae population of limited geographical origin",

abstract = "A collection of 185 Streptococcus pneumoniae isolates was tested for their susceptibility to antipneumococcal drugs, with a focus on the distribution of tetracycline resistance determinants tet(M) and tet(O). Resistance patterns were compared with established correlates of multidrug resistance, and tetracycline-resistant isolates were tested for clonality and allelic variation within tet(M). Resistance to tetracyclines, penicillins and macrolides were all strongly related to multidrug resistance. Over one-quarter of the strains were tetracycline resistant, all via the tet(M)-mediated mechanism. Restriction fragment length polymorphism analysis revealed a high degree of allelic variation within tet(M) and gave evidence of a clonal and horizontal spread of selected alleles. A tet(M) variant that emerged with the onset of epidemic multidrug-resistant strains was replacing old alleles in the population.",

keywords = "Streptococcus pneumoniae, tet(M), Tetracycline",

author = "Katarzyna Dzieranowska-Fangrat and Katarzyna Semczuk and Paulina G{\'o}rska and Stefania Giedrys-Kalemba and Maria Kochman and Alfred Samet and Stefan Tyski and Danuta Dzieranowska and Krzysztof Trzci{\'n}ski",

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Dzieranowska-Fangrat, K, Semczuk, K, Górska, P, Giedrys-Kalemba, S, Kochman, M, Samet, A, Tyski, S, Dzieranowska, D & Trzciński, K 2006, 'Evidence for tetracycline resistance determinant tet(M) allele replacement in a Streptococcus pneumoniae population of limited geographical origin', International Journal of Antimicrobial Agents, vol. 27, no. 2, pp. 159-164. https://doi.org/10.1016/j.ijantimicag.2005.10.003

Evidence for tetracycline resistance determinant tet(M) allele replacement in a Streptococcus pneumoniae population of limited geographical origin. / Dzieranowska-Fangrat, Katarzyna; Semczuk, Katarzyna; Górska, Paulina et al.
In: International Journal of Antimicrobial Agents, Vol. 27, No. 2, 01.02.2006, p. 159-164.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Evidence for tetracycline resistance determinant tet(M) allele replacement in a Streptococcus pneumoniae population of limited geographical origin

AU - Dzieranowska-Fangrat, Katarzyna

AU - Semczuk, Katarzyna

AU - Górska, Paulina

AU - Giedrys-Kalemba, Stefania

AU - Kochman, Maria

AU - Samet, Alfred

AU - Tyski, Stefan

AU - Dzieranowska, Danuta

AU - Trzciński, Krzysztof

PY - 2006/2/1

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N2 - A collection of 185 Streptococcus pneumoniae isolates was tested for their susceptibility to antipneumococcal drugs, with a focus on the distribution of tetracycline resistance determinants tet(M) and tet(O). Resistance patterns were compared with established correlates of multidrug resistance, and tetracycline-resistant isolates were tested for clonality and allelic variation within tet(M). Resistance to tetracyclines, penicillins and macrolides were all strongly related to multidrug resistance. Over one-quarter of the strains were tetracycline resistant, all via the tet(M)-mediated mechanism. Restriction fragment length polymorphism analysis revealed a high degree of allelic variation within tet(M) and gave evidence of a clonal and horizontal spread of selected alleles. A tet(M) variant that emerged with the onset of epidemic multidrug-resistant strains was replacing old alleles in the population.

AB - A collection of 185 Streptococcus pneumoniae isolates was tested for their susceptibility to antipneumococcal drugs, with a focus on the distribution of tetracycline resistance determinants tet(M) and tet(O). Resistance patterns were compared with established correlates of multidrug resistance, and tetracycline-resistant isolates were tested for clonality and allelic variation within tet(M). Resistance to tetracyclines, penicillins and macrolides were all strongly related to multidrug resistance. Over one-quarter of the strains were tetracycline resistant, all via the tet(M)-mediated mechanism. Restriction fragment length polymorphism analysis revealed a high degree of allelic variation within tet(M) and gave evidence of a clonal and horizontal spread of selected alleles. A tet(M) variant that emerged with the onset of epidemic multidrug-resistant strains was replacing old alleles in the population.

KW - Streptococcus pneumoniae

KW - tet(M)

KW - Tetracycline

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M3 - Article

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AN - SCOPUS:31344433227

SN - 0924-8579

VL - 27

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EP - 164

JO - International Journal of Antimicrobial Agents

JF - International Journal of Antimicrobial Agents

IS - 2

ER -

Evidence for tetracycline resistance determinant tet(M) allele replacement in a Streptococcus pneumoniae population of limited geographical origin

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