TY - JOUR
T1 - Evidence for tetracycline resistance determinant tet(M) allele replacement in a Streptococcus pneumoniae population of limited geographical origin
AU - Dzieranowska-Fangrat, Katarzyna
AU - Semczuk, Katarzyna
AU - Górska, Paulina
AU - Giedrys-Kalemba, Stefania
AU - Kochman, Maria
AU - Samet, Alfred
AU - Tyski, Stefan
AU - Dzieranowska, Danuta
AU - Trzciński, Krzysztof
PY - 2006/2/1
Y1 - 2006/2/1
N2 - A collection of 185 Streptococcus pneumoniae isolates was tested for their susceptibility to antipneumococcal drugs, with a focus on the distribution of tetracycline resistance determinants tet(M) and tet(O). Resistance patterns were compared with established correlates of multidrug resistance, and tetracycline-resistant isolates were tested for clonality and allelic variation within tet(M). Resistance to tetracyclines, penicillins and macrolides were all strongly related to multidrug resistance. Over one-quarter of the strains were tetracycline resistant, all via the tet(M)-mediated mechanism. Restriction fragment length polymorphism analysis revealed a high degree of allelic variation within tet(M) and gave evidence of a clonal and horizontal spread of selected alleles. A tet(M) variant that emerged with the onset of epidemic multidrug-resistant strains was replacing old alleles in the population.
AB - A collection of 185 Streptococcus pneumoniae isolates was tested for their susceptibility to antipneumococcal drugs, with a focus on the distribution of tetracycline resistance determinants tet(M) and tet(O). Resistance patterns were compared with established correlates of multidrug resistance, and tetracycline-resistant isolates were tested for clonality and allelic variation within tet(M). Resistance to tetracyclines, penicillins and macrolides were all strongly related to multidrug resistance. Over one-quarter of the strains were tetracycline resistant, all via the tet(M)-mediated mechanism. Restriction fragment length polymorphism analysis revealed a high degree of allelic variation within tet(M) and gave evidence of a clonal and horizontal spread of selected alleles. A tet(M) variant that emerged with the onset of epidemic multidrug-resistant strains was replacing old alleles in the population.
KW - Streptococcus pneumoniae
KW - tet(M)
KW - Tetracycline
UR - http://www.scopus.com/inward/record.url?scp=31344433227&partnerID=8YFLogxK
U2 - 10.1016/j.ijantimicag.2005.10.003
DO - 10.1016/j.ijantimicag.2005.10.003
M3 - Article
C2 - 16423511
AN - SCOPUS:31344433227
SN - 0924-8579
VL - 27
SP - 159
EP - 164
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
IS - 2
ER -