Evidence for tetracycline resistance determinant tet(M) allele replacement in a Streptococcus pneumoniae population of limited geographical origin

Katarzyna Dzieranowska-Fangrat, Katarzyna Semczuk, Paulina Górska, Stefania Giedrys-Kalemba, Maria Kochman, Alfred Samet, Stefan Tyski, Danuta Dzieranowska, Krzysztof Trzciński*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Abstract

A collection of 185 Streptococcus pneumoniae isolates was tested for their susceptibility to antipneumococcal drugs, with a focus on the distribution of tetracycline resistance determinants tet(M) and tet(O). Resistance patterns were compared with established correlates of multidrug resistance, and tetracycline-resistant isolates were tested for clonality and allelic variation within tet(M). Resistance to tetracyclines, penicillins and macrolides were all strongly related to multidrug resistance. Over one-quarter of the strains were tetracycline resistant, all via the tet(M)-mediated mechanism. Restriction fragment length polymorphism analysis revealed a high degree of allelic variation within tet(M) and gave evidence of a clonal and horizontal spread of selected alleles. A tet(M) variant that emerged with the onset of epidemic multidrug-resistant strains was replacing old alleles in the population.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalInternational Journal of Antimicrobial Agents
Volume27
Issue number2
DOIs
Publication statusPublished - 1 Feb 2006

Keywords

  • Streptococcus pneumoniae
  • tet(M)
  • Tetracycline

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