Evaluation of GenoFlow DR-MTB array test for detection of rifampin and isoniazid resistance in mycobacterium tuberculosis

B. Molina-Moya; G. Kazdaglis; A. Lacoma; C. Prat; A. Gómez; R. Villar-Hernández; E. García-García; L. Haba; J. Maldonado; S. Samper; J. Ruiz-Manzano; V. Ausina; J. Domínguez

doi:10.1128/JCM.03341-15

Evaluation of GenoFlow DR-MTB array test for detection of rifampin and isoniazid resistance in mycobacterium tuberculosis

B. Molina-Moya, G. Kazdaglis, A. Lacoma, C. Prat, A. Gómez, R. Villar-Hernández, E. García-García, L. Haba, J. Maldonado, S. Samper, J. Ruiz-Manzano, V. Ausina, J. Domínguez^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

3 Citations (Scopus)

Abstract

The aim of this study was to evaluate the GenoFlow DR-MTB array test (DiagCor Bioscience, Hong Kong) on 70 cultured isolates and 50 sputum specimens. The GenoFlow array test showed good sensitivity and specificity compared to the phenotypic Bactec 460TB. This array accurately detected mutations in rpoB, katG, and inhA associated with resistance to rifampin and isoniazid.

Original language	English
Pages (from-to)	1160-1163
Number of pages	4
Journal	Journal of Clinical Microbiology
Volume	54
Issue number	4
DOIs	https://doi.org/10.1128/JCM.03341-15
Publication status	Published - Apr 2016
Externally published	Yes

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Molina-Moya, B., Kazdaglis, G., Lacoma, A., Prat, C., Gómez, A., Villar-Hernández, R., García-García, E., Haba, L., Maldonado, J., Samper, S., Ruiz-Manzano, J., Ausina, V., & Domínguez, J. (2016). Evaluation of GenoFlow DR-MTB array test for detection of rifampin and isoniazid resistance in mycobacterium tuberculosis. Journal of Clinical Microbiology, 54(4), 1160-1163. https://doi.org/10.1128/JCM.03341-15

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abstract = "The aim of this study was to evaluate the GenoFlow DR-MTB array test (DiagCor Bioscience, Hong Kong) on 70 cultured isolates and 50 sputum specimens. The GenoFlow array test showed good sensitivity and specificity compared to the phenotypic Bactec 460TB. This array accurately detected mutations in rpoB, katG, and inhA associated with resistance to rifampin and isoniazid.",

author = "B. Molina-Moya and G. Kazdaglis and A. Lacoma and C. Prat and A. G{\'o}mez and R. Villar-Hern{\'a}ndez and E. Garc{\'i}a-Garc{\'i}a and L. Haba and J. Maldonado and S. Samper and J. Ruiz-Manzano and V. Ausina and J. Dom{\'i}nguez",

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Molina-Moya, B, Kazdaglis, G, Lacoma, A, Prat, C, Gómez, A, Villar-Hernández, R, García-García, E, Haba, L, Maldonado, J, Samper, S, Ruiz-Manzano, J, Ausina, V & Domínguez, J 2016, 'Evaluation of GenoFlow DR-MTB array test for detection of rifampin and isoniazid resistance in mycobacterium tuberculosis', Journal of Clinical Microbiology, vol. 54, no. 4, pp. 1160-1163. https://doi.org/10.1128/JCM.03341-15

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T1 - Evaluation of GenoFlow DR-MTB array test for detection of rifampin and isoniazid resistance in mycobacterium tuberculosis

AU - Molina-Moya, B.

AU - Kazdaglis, G.

AU - Lacoma, A.

AU - Prat, C.

AU - Gómez, A.

AU - Villar-Hernández, R.

AU - García-García, E.

AU - Haba, L.

AU - Maldonado, J.

AU - Samper, S.

AU - Ruiz-Manzano, J.

AU - Ausina, V.

AU - Domínguez, J.

PY - 2016/4

Y1 - 2016/4

N2 - The aim of this study was to evaluate the GenoFlow DR-MTB array test (DiagCor Bioscience, Hong Kong) on 70 cultured isolates and 50 sputum specimens. The GenoFlow array test showed good sensitivity and specificity compared to the phenotypic Bactec 460TB. This array accurately detected mutations in rpoB, katG, and inhA associated with resistance to rifampin and isoniazid.

AB - The aim of this study was to evaluate the GenoFlow DR-MTB array test (DiagCor Bioscience, Hong Kong) on 70 cultured isolates and 50 sputum specimens. The GenoFlow array test showed good sensitivity and specificity compared to the phenotypic Bactec 460TB. This array accurately detected mutations in rpoB, katG, and inhA associated with resistance to rifampin and isoniazid.

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SN - 0095-1137

VL - 54

SP - 1160

EP - 1163

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

IS - 4

ER -

Evaluation of GenoFlow DR-MTB array test for detection of rifampin and isoniazid resistance in mycobacterium tuberculosis

Abstract

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