Evaluating the credibility of anchor based estimates of minimal important differences for patient reported outcomes: instrument development and reliability study

  • Tahira Devji
  • , Alonso Carrasco-Labra
  • , Anila Qasim
  • , Mark Phillips
  • , Bradley C Johnston
  • , Niveditha Devasenapathy
  • , Dena Zeraatkar
  • , Meha Bhatt
  • , Xuejing Jin
  • , Romina Brignardello-Petersen
  • , Olivia Urquhart
  • , Farid Foroutan
  • , Stefan Schandelmaier
  • , Hector Pardo-Hernandez
  • , Robin Wm Vernooij
  • , Hsiaomin Huang
  • , Yamna Rizwan
  • , Reed Siemieniuk
  • , Lyubov Lytvyn
  • , Donald L Patrick
  • Shanil Ebrahim, Toshi Furukawa, Gihad Nesrallah, Holger J Schünemann, Mohit Bhandari, Lehana Thabane, Gordon H Guyatt

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

OBJECTIVE: To develop an instrument to evaluate the credibility of anchor based minimal important differences (MIDs) for outcome measures reported by patients, and to assess the reliability of the instrument.

DESIGN: Instrument development and reliability study.

DATA SOURCES: Initial criteria were developed for evaluating the credibility of anchor based MIDs based on a literature review (Medline, Embase, CINAHL, and PsycInfo databases) and the experience of the authors in the methodology for estimation of MIDs. Iterative discussions by the team and pilot testing with experts and potential users facilitated the development of the final instrument.

PARTICIPANTS: With the newly developed instrument, pairs of masters, doctoral, or postdoctoral students with a background in health research methodology independently evaluated the credibility of a sample of MID estimates.

MAIN OUTCOME MEASURES: Core credibility criteria applicable to all anchor types, additional criteria for transition rating anchors, and inter-rater reliability coefficients were determined.

RESULTS: The credibility instrument has five core criteria: the anchor is rated by the patient; the anchor is interpretable and relevant to the patient; the MID estimate is precise; the correlation between the anchor and the outcome measure reported by the patient is satisfactory; and the authors select a threshold on the anchor that reflects a small but important difference. The additional criteria for transition rating anchors are: the time elapsed between baseline and follow-up measurement for estimation of the MID is optimal; and the correlations of the transition rating with the baseline, follow-up, and change score in the patient reported outcome measures are satisfactory. Inter-rater reliability coefficients (ĸ) for the core criteria and for one item from the additional criteria ranged from 0.70 to 0.94. Reporting issues prevented the evaluation of the reliability of the three other additional criteria for the transition rating anchors.

CONCLUSIONS: Researchers, clinicians, and healthcare policy decision makers can consider using this instrument to evaluate the design, conduct, and analysis of studies estimating anchor based minimal important differences.

Original languageEnglish
Article numberm1714
Pages (from-to)m1714
JournalBMJ (Clinical research ed.)
Volume369
DOIs
Publication statusPublished - 4 Jun 2020
Externally publishedYes

Keywords

  • Health Status Indicators
  • Humans
  • Patient Reported Outcome Measures
  • Quality of Life
  • Reproducibility of Results
  • Research Design
  • Surveys and Questionnaires

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