TY - JOUR
T1 - European practice on neurovascular late effects after pediatric radiotherapy
T2 - considerations on dose planning and follow-up - a HARMONIC/SIOPE ROWG survey
AU - Toussaint, Laura
AU - Tram Henriksen, Louise
AU - Van Beek, Karen
AU - Bolle, Stephanie
AU - Demoor-Goldschmidt, Charlotte
AU - Gains, Jenny
AU - Høyer, Morten
AU - Janssens, Geert O
AU - Kortmann, Rolf-Dieter
AU - Martins Pedro, Catia
AU - Timmermann, Beate
AU - Scheinemann, Katrin
AU - Lassen-Ramshad, Yasmin
N1 - Publisher Copyright:
© 2025 The Author(s).
PY - 2025/5/22
Y1 - 2025/5/22
N2 - BACKGROUND AND PURPOSE: The risk of developing neurovascular late effects after radiotherapy is an area of concern when treating pediatric brain tumor patients. However, knowledge is sparse regarding best practice for clinical management during the radiotherapy (RT) planning process and follow-up examinations. This study therefore aimed at mapping how the risk of neurovascular late effects is considered for pediatric brain or skull base tumor patients treated with radiotherapy in Europe.MATERIALS AND METHODS: Two web-based surveys ‑ a RT and a pediatric oncology (PO) survey - were distributed to members of the SIOPE radiotherapy working group or PANCARE and SIOPE brain tumor group, respectively.RESULTS: The RT survey was completed by 47 participants from 18 different European countries and the PO survey by 33 participants (mostly pediatric (neuro)oncologists) from 15 countries. Overall, the answers highlighted that neurovascular late effects are currently not well included in European clinical practice, neither at the time of radiotherapy nor in the follow-up process.INTERPRETATION: There is a need for raising general awareness about the topic, as well as for potential risk-stratified prevention measures and follow-up guidelines.
AB - BACKGROUND AND PURPOSE: The risk of developing neurovascular late effects after radiotherapy is an area of concern when treating pediatric brain tumor patients. However, knowledge is sparse regarding best practice for clinical management during the radiotherapy (RT) planning process and follow-up examinations. This study therefore aimed at mapping how the risk of neurovascular late effects is considered for pediatric brain or skull base tumor patients treated with radiotherapy in Europe.MATERIALS AND METHODS: Two web-based surveys ‑ a RT and a pediatric oncology (PO) survey - were distributed to members of the SIOPE radiotherapy working group or PANCARE and SIOPE brain tumor group, respectively.RESULTS: The RT survey was completed by 47 participants from 18 different European countries and the PO survey by 33 participants (mostly pediatric (neuro)oncologists) from 15 countries. Overall, the answers highlighted that neurovascular late effects are currently not well included in European clinical practice, neither at the time of radiotherapy nor in the follow-up process.INTERPRETATION: There is a need for raising general awareness about the topic, as well as for potential risk-stratified prevention measures and follow-up guidelines.
KW - Brain Neoplasms/radiotherapy
KW - Child
KW - Europe
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Male
KW - Practice Patterns, Physicians'/statistics & numerical data
KW - Radiation Injuries/etiology
KW - Radiotherapy Dosage
KW - Radiotherapy Planning, Computer-Assisted/methods
KW - Skull Base Neoplasms/radiotherapy
KW - Surveys and Questionnaires
U2 - 10.2340/1651-226X.2025.43028
DO - 10.2340/1651-226X.2025.43028
M3 - Article
C2 - 40402041
SN - 0284-186X
VL - 64
SP - 703
EP - 707
JO - Acta Oncologica
JF - Acta Oncologica
ER -