European consensus-based interdisciplinary guideline for invasive cutaneous squamous cell carcinoma. Part 1: Diagnostics and prevention–Update 2023

  • Alexander J. Stratigos*
  • , Claus Garbe
  • , Clio Dessinioti
  • , Celeste Lebbe
  • , Alexander van Akkooi
  • , Veronique Bataille
  • , Lars Bastholt
  • , Brigitte Dreno
  • , Reinhard Dummer
  • , Maria Concetta Fargnoli
  • , Ana Maria Forsea
  • , Catherine A. Harwood
  • , Axel Hauschild
  • , Christoph Hoeller
  • , Lidija Kandolf-Sekulovic
  • , Roland Kaufmann
  • , Nicole WJ Kelleners-Smeets
  • , Aimilios Lallas
  • , Ulrike Leiter
  • , Josep Malvehy
  • Veronique del Marmol, David Moreno-Ramirez, Giovanni Pellacani, Ketty Peris, Philippe Saiag, Luca Tagliaferri, Myrto Trakatelli, Dimitrios Ioannides, Ricardo Vieira, Iris Zalaudek, Petr Arenberger, Alexander M.M. Eggermont, Martin Röcken, Jean Jacques Grob, Paul Lorigan,
*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Invasive cutaneous squamous cell carcinoma (cSCC) is one of the most common cancers in white populations, accounting for 20% of all cutaneous malignancies. Overall, cSCC mostly has very good prognosis after treatment, with 5-year cure rates greater than 90%. Despite the overall favourable prognosis and the proportionally rare deaths, cSCC is associated with a high total number of deaths due to its high incidence. A collaboration of multidisciplinary experts from the European Association of Dermato-Oncology (EADO), the European Dermatology Forum (EDF), the European Society for Radiotherapy and Oncology (ESTRO), the European Union of Medical Specialists (UEMS), the European Academy of Dermatology and Venereology (EADV) and the European Organization of Research and Treatment of Cancer (EORTC), was formed to update recommendations on cSCC, based on current literature and expert consensus. Part 1 of the guidelines addresses the updates on classification, epidemiology, diagnosis, risk stratification, staging and prevention in immunocompetent as well as immunosuppressed patients.

Original languageEnglish
Article number113251
JournalEuropean Journal of Cancer
Volume193
DOIs
Publication statusPublished - Nov 2023

Keywords

  • Advanced
  • Diagnosis
  • High-risk
  • Immunosuppression
  • Invasive cutaneous squamous cell carcinoma
  • Locally advanced cSCC
  • Metastatic cSCC
  • Prevention
  • Prognosis
  • Staging

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