ESTRO ACROP guidelines for external beam radiotherapy of patients with complicated bone metastases

Eva Oldenburger, Stephanie Brown, Jonas Willmann, Joanne M. van der Velden, Mateusz Spałek, Yvette M. van der Linden, Joanna Kazmierska, Johan Menten, Nicolaus Andratschke, Peter Hoskin*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Abstract

This is the second part of the guidelines on the management of bone metastases. In the first part, the diagnosis and management of uncomplicated bone metastases have been addressed. Bone metastases may significantly reduce quality of life due to related symptoms and possible complications. The most common symptoms include pain and neurologic deficits. The most serious complications of bone metastases are skeletal-related events (SRE), defined as pathologic fracture, spinal cord compression, pain, or other symptoms requiring an urgent intervention such as surgery or radiotherapy. Diffuse bone metastases may lead to hypercalcaemia that can be fatal if untreated. The growing access to modern diagnostic tools allows early detection of asymptomatic bone metastases that could be successfully managed with local treatment if oligometastatic or systemic treatment for diffuse bone metastases to try to avoid the development of SRE.

Original languageEnglish
Pages (from-to)240-253
Number of pages14
JournalRadiotherapy and Oncology
Volume173
DOIs
Publication statusPublished - Aug 2022
Externally publishedYes

Keywords

  • Bone metastases
  • Complicated
  • Cord compression
  • Dose fractionation
  • Fracture
  • Neuropathic pain
  • Prophylaxis
  • Stereotactic
  • Fractures, Spontaneous/etiology
  • Humans
  • Spinal Cord Compression/etiology
  • Pain/etiology
  • Quality of Life
  • Bone Neoplasms/drug therapy

Fingerprint

Dive into the research topics of 'ESTRO ACROP guidelines for external beam radiotherapy of patients with complicated bone metastases'. Together they form a unique fingerprint.

Cite this