Estimation of Total Kidney Volume in Autosomal Dominant Polycystic Kidney Disease

Edwin M. Spithoven; Maatje D A van Gastel; A. Lianne Messchendorp; Niek F. Casteleijn; Joost P. H. Drenth; Carlo A. Gaillard; Johan W de Fijter; Esther Meijer; Dorien J M Peters; Peter Kappert; Remco J. Renken; Folkert W. Visser; Jack F. M. Wetzels; Robert Zietse; Ron T. Gansevoort; DIPAK Consortium

doi:10.1053/j.ajkd.2015.06.017

Estimation of Total Kidney Volume in Autosomal Dominant Polycystic Kidney Disease

Edwin M. Spithoven, Maatje D A van Gastel, A. Lianne Messchendorp, Niek F. Casteleijn, Joost P. H. Drenth, Carlo A. Gaillard, Johan W de Fijter, Esther Meijer, Dorien J M Peters, Peter Kappert, Remco J. Renken, Folkert W. Visser, Jack F. M. Wetzels, Robert Zietse, Ron T. Gansevoort, DIPAK Consortium

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: In autosomal dominant polycystic kidney disease (ADPKD), obtaining measured total kidney volume (mTKV) by magnetic resonance (MR) imaging and manual tracing is time consuming. Two alternative MR imaging methods have recently been proposed to estimate TKV (eTKV(ellipsoid) and eTKV(PANK)), which require less time.Study Design: Cross-sectional and longitudinal diagnostic test study.Setting & Participants: Patients with ADPKD with a wide range of kidney function and an approved T2-weighted MR image obtained at the University Medical Centers of Groningen, Leiden, Nijmegen, and Rotterdam, the Netherlands, in 2007 to 2014. Test set for assessing reproducibility, n = 10; cohort for cross-sectional analyses, n = 220; and cohort for longitudinal analyses, n = 48.Index Tests: Average times for eTKV(ellipsoid) and eTKV(PANK) were 5 and 15 minutes, respectively. Bias is defined as (mTKV - eTKV)/mTKV x 100%; precision, as one standard deviation of bias.Reference Tests: mTKV using manual tracing to calculate the area within kidney boundaries times slice thickness. Average time for mTKV was 55 minutes.Results: In the test set, intra- and intercoefficients of variation for mTKV, eTKV(ellipsoid), and eTKV(PANK) were 1.8% and 2.3%, 3.9% and 6.3%, and 3.0% and 3.4%, respectively. In cross-sectional analysis, baseline mTKV, eTKV(ellipsoid), and eTKV(PANK) were 1.96 (IQR, 1.28-2.82), 1.93 (IQR, 1.25-2.82), and 1.81 (IQR, 1.17-2.62) L, respectively. In cross-sectional analysis, bias was 0.02% +/- 3.2%, 1.4% +/- 9.2%, and 4.6% +/- 7.6% for repeat mTKV, eTKV(ellipsoid), and eTKV(PANK), respectively. In longitudinal analysis, no significant differences were observed between percentage change in mTKV (16.7% +/- 17.1%) and percentage change in eTKV(ellipsoid) (19.3% 6 16.1%) and eTKV(PANK) (17.8% +/- 16.1%) over 3 years.Limitations: Results for follow-up data should be interpreted with caution because of the limited number of patients.Conclusions: Both methods for eTKV perform relatively well compared to mTKV and can detect change in TKV over time. Because eTKV(ellipsoid) requires less time than eTKV(PANK), we suggest that this method may be preferable in clinical care. (C) 2015 by the National Kidney Foundation, Inc.

Original language	English
Pages (from-to)	792-801
Number of pages	10
Journal	American Journal of Kidney Diseases
Volume	66
Issue number	5
DOIs	https://doi.org/10.1053/j.ajkd.2015.06.017
Publication status	Published - Nov 2015
Externally published	Yes

Keywords

Autosomal dominant polycystic kidney disease (ADPKD)
total kidney volume (TKV)
magnetic resonance imaging (MRI)
estimation methods
ellipsoid
PANK
validation
ADPKD
PROGRESSION
TOLVAPTAN
TRIALS
DESIGN

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10.1053/j.ajkd.2015.06.017

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Spithoven, E. M., van Gastel, M. D. A., Messchendorp, A. L., Casteleijn, N. F., Drenth, J. P. H., Gaillard, C. A., de Fijter, J. W., Meijer, E., Peters, D. J. M., Kappert, P., Renken, R. J., Visser, F. W., Wetzels, J. F. M., Zietse, R., Gansevoort, R. T., & Consortium, DIPAK. (2015). Estimation of Total Kidney Volume in Autosomal Dominant Polycystic Kidney Disease. American Journal of Kidney Diseases, 66(5), 792-801. https://doi.org/10.1053/j.ajkd.2015.06.017

@article{e7507c3938d24ea08a67320ddca1597e,

title = "Estimation of Total Kidney Volume in Autosomal Dominant Polycystic Kidney Disease",

abstract = "Background: In autosomal dominant polycystic kidney disease (ADPKD), obtaining measured total kidney volume (mTKV) by magnetic resonance (MR) imaging and manual tracing is time consuming. Two alternative MR imaging methods have recently been proposed to estimate TKV (eTKV(ellipsoid) and eTKV(PANK)), which require less time.Study Design: Cross-sectional and longitudinal diagnostic test study.Setting & Participants: Patients with ADPKD with a wide range of kidney function and an approved T2-weighted MR image obtained at the University Medical Centers of Groningen, Leiden, Nijmegen, and Rotterdam, the Netherlands, in 2007 to 2014. Test set for assessing reproducibility, n = 10; cohort for cross-sectional analyses, n = 220; and cohort for longitudinal analyses, n = 48.Index Tests: Average times for eTKV(ellipsoid) and eTKV(PANK) were 5 and 15 minutes, respectively. Bias is defined as (mTKV - eTKV)/mTKV x 100%; precision, as one standard deviation of bias.Reference Tests: mTKV using manual tracing to calculate the area within kidney boundaries times slice thickness. Average time for mTKV was 55 minutes.Results: In the test set, intra- and intercoefficients of variation for mTKV, eTKV(ellipsoid), and eTKV(PANK) were 1.8% and 2.3%, 3.9% and 6.3%, and 3.0% and 3.4%, respectively. In cross-sectional analysis, baseline mTKV, eTKV(ellipsoid), and eTKV(PANK) were 1.96 (IQR, 1.28-2.82), 1.93 (IQR, 1.25-2.82), and 1.81 (IQR, 1.17-2.62) L, respectively. In cross-sectional analysis, bias was 0.02% +/- 3.2%, 1.4% +/- 9.2%, and 4.6% +/- 7.6% for repeat mTKV, eTKV(ellipsoid), and eTKV(PANK), respectively. In longitudinal analysis, no significant differences were observed between percentage change in mTKV (16.7% +/- 17.1%) and percentage change in eTKV(ellipsoid) (19.3% 6 16.1%) and eTKV(PANK) (17.8% +/- 16.1%) over 3 years.Limitations: Results for follow-up data should be interpreted with caution because of the limited number of patients.Conclusions: Both methods for eTKV perform relatively well compared to mTKV and can detect change in TKV over time. Because eTKV(ellipsoid) requires less time than eTKV(PANK), we suggest that this method may be preferable in clinical care. (C) 2015 by the National Kidney Foundation, Inc.",

keywords = "Autosomal dominant polycystic kidney disease (ADPKD), total kidney volume (TKV), magnetic resonance imaging (MRI), estimation methods, ellipsoid, PANK, validation, ADPKD, PROGRESSION, TOLVAPTAN, TRIALS, DESIGN",

author = "Spithoven, {Edwin M.} and {van Gastel}, {Maatje D A} and Messchendorp, {A. Lianne} and Casteleijn, {Niek F.} and Drenth, {Joost P. H.} and Gaillard, {Carlo A.} and {de Fijter}, {Johan W} and Esther Meijer and Peters, {Dorien J M} and Peter Kappert and Renken, {Remco J.} and Visser, {Folkert W.} and Wetzels, {Jack F. M.} and Robert Zietse and Gansevoort, {Ron T.} and DIPAK Consortium",

year = "2015",

month = nov,

doi = "10.1053/j.ajkd.2015.06.017",

language = "English",

volume = "66",

pages = "792--801",

journal = "American Journal of Kidney Diseases",

issn = "0272-6386",

publisher = "W.B. Saunders Ltd",

number = "5",

}

Spithoven, EM, van Gastel, MDA, Messchendorp, AL, Casteleijn, NF, Drenth, JPH, Gaillard, CA, de Fijter, JW, Meijer, E, Peters, DJM, Kappert, P, Renken, RJ, Visser, FW, Wetzels, JFM, Zietse, R, Gansevoort, RT & Consortium, DIPAK 2015, 'Estimation of Total Kidney Volume in Autosomal Dominant Polycystic Kidney Disease', American Journal of Kidney Diseases, vol. 66, no. 5, pp. 792-801. https://doi.org/10.1053/j.ajkd.2015.06.017

TY - JOUR

T1 - Estimation of Total Kidney Volume in Autosomal Dominant Polycystic Kidney Disease

AU - Spithoven, Edwin M.

AU - van Gastel, Maatje D A

AU - Messchendorp, A. Lianne

AU - Casteleijn, Niek F.

AU - Drenth, Joost P. H.

AU - Gaillard, Carlo A.

AU - de Fijter, Johan W

AU - Meijer, Esther

AU - Peters, Dorien J M

AU - Kappert, Peter

AU - Renken, Remco J.

AU - Visser, Folkert W.

AU - Wetzels, Jack F. M.

AU - Zietse, Robert

AU - Gansevoort, Ron T.

AU - Consortium, DIPAK

PY - 2015/11

Y1 - 2015/11

N2 - Background: In autosomal dominant polycystic kidney disease (ADPKD), obtaining measured total kidney volume (mTKV) by magnetic resonance (MR) imaging and manual tracing is time consuming. Two alternative MR imaging methods have recently been proposed to estimate TKV (eTKV(ellipsoid) and eTKV(PANK)), which require less time.Study Design: Cross-sectional and longitudinal diagnostic test study.Setting & Participants: Patients with ADPKD with a wide range of kidney function and an approved T2-weighted MR image obtained at the University Medical Centers of Groningen, Leiden, Nijmegen, and Rotterdam, the Netherlands, in 2007 to 2014. Test set for assessing reproducibility, n = 10; cohort for cross-sectional analyses, n = 220; and cohort for longitudinal analyses, n = 48.Index Tests: Average times for eTKV(ellipsoid) and eTKV(PANK) were 5 and 15 minutes, respectively. Bias is defined as (mTKV - eTKV)/mTKV x 100%; precision, as one standard deviation of bias.Reference Tests: mTKV using manual tracing to calculate the area within kidney boundaries times slice thickness. Average time for mTKV was 55 minutes.Results: In the test set, intra- and intercoefficients of variation for mTKV, eTKV(ellipsoid), and eTKV(PANK) were 1.8% and 2.3%, 3.9% and 6.3%, and 3.0% and 3.4%, respectively. In cross-sectional analysis, baseline mTKV, eTKV(ellipsoid), and eTKV(PANK) were 1.96 (IQR, 1.28-2.82), 1.93 (IQR, 1.25-2.82), and 1.81 (IQR, 1.17-2.62) L, respectively. In cross-sectional analysis, bias was 0.02% +/- 3.2%, 1.4% +/- 9.2%, and 4.6% +/- 7.6% for repeat mTKV, eTKV(ellipsoid), and eTKV(PANK), respectively. In longitudinal analysis, no significant differences were observed between percentage change in mTKV (16.7% +/- 17.1%) and percentage change in eTKV(ellipsoid) (19.3% 6 16.1%) and eTKV(PANK) (17.8% +/- 16.1%) over 3 years.Limitations: Results for follow-up data should be interpreted with caution because of the limited number of patients.Conclusions: Both methods for eTKV perform relatively well compared to mTKV and can detect change in TKV over time. Because eTKV(ellipsoid) requires less time than eTKV(PANK), we suggest that this method may be preferable in clinical care. (C) 2015 by the National Kidney Foundation, Inc.

AB - Background: In autosomal dominant polycystic kidney disease (ADPKD), obtaining measured total kidney volume (mTKV) by magnetic resonance (MR) imaging and manual tracing is time consuming. Two alternative MR imaging methods have recently been proposed to estimate TKV (eTKV(ellipsoid) and eTKV(PANK)), which require less time.Study Design: Cross-sectional and longitudinal diagnostic test study.Setting & Participants: Patients with ADPKD with a wide range of kidney function and an approved T2-weighted MR image obtained at the University Medical Centers of Groningen, Leiden, Nijmegen, and Rotterdam, the Netherlands, in 2007 to 2014. Test set for assessing reproducibility, n = 10; cohort for cross-sectional analyses, n = 220; and cohort for longitudinal analyses, n = 48.Index Tests: Average times for eTKV(ellipsoid) and eTKV(PANK) were 5 and 15 minutes, respectively. Bias is defined as (mTKV - eTKV)/mTKV x 100%; precision, as one standard deviation of bias.Reference Tests: mTKV using manual tracing to calculate the area within kidney boundaries times slice thickness. Average time for mTKV was 55 minutes.Results: In the test set, intra- and intercoefficients of variation for mTKV, eTKV(ellipsoid), and eTKV(PANK) were 1.8% and 2.3%, 3.9% and 6.3%, and 3.0% and 3.4%, respectively. In cross-sectional analysis, baseline mTKV, eTKV(ellipsoid), and eTKV(PANK) were 1.96 (IQR, 1.28-2.82), 1.93 (IQR, 1.25-2.82), and 1.81 (IQR, 1.17-2.62) L, respectively. In cross-sectional analysis, bias was 0.02% +/- 3.2%, 1.4% +/- 9.2%, and 4.6% +/- 7.6% for repeat mTKV, eTKV(ellipsoid), and eTKV(PANK), respectively. In longitudinal analysis, no significant differences were observed between percentage change in mTKV (16.7% +/- 17.1%) and percentage change in eTKV(ellipsoid) (19.3% 6 16.1%) and eTKV(PANK) (17.8% +/- 16.1%) over 3 years.Limitations: Results for follow-up data should be interpreted with caution because of the limited number of patients.Conclusions: Both methods for eTKV perform relatively well compared to mTKV and can detect change in TKV over time. Because eTKV(ellipsoid) requires less time than eTKV(PANK), we suggest that this method may be preferable in clinical care. (C) 2015 by the National Kidney Foundation, Inc.

KW - Autosomal dominant polycystic kidney disease (ADPKD)

KW - total kidney volume (TKV)

KW - magnetic resonance imaging (MRI)

KW - estimation methods

KW - ellipsoid

KW - PANK

KW - validation

KW - ADPKD

KW - PROGRESSION

KW - TOLVAPTAN

KW - TRIALS

KW - DESIGN

U2 - 10.1053/j.ajkd.2015.06.017

DO - 10.1053/j.ajkd.2015.06.017

M3 - Article

SN - 0272-6386

VL - 66

SP - 792

EP - 801

JO - American Journal of Kidney Diseases

JF - American Journal of Kidney Diseases

IS - 5

ER -

Estimation of Total Kidney Volume in Autosomal Dominant Polycystic Kidney Disease

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Keywords

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