Esophageal second primary tumors in patients with head and neck squamous cell carcinoma: incidence, risk factors and overall survival

Anouk Overwater; Kuna Rueb; Sjoerd G Elias; Remco de Bree; Bas L A M Weusten

doi:10.14309/ajg.0000000000001711

Esophageal second primary tumors in patients with head and neck squamous cell carcinoma: incidence, risk factors and overall survival

Anouk Overwater, Kuna Rueb, Sjoerd G Elias, Remco de Bree, Bas L A M Weusten

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

INTRODUCTION: The aim of this registry-based cohort study was to evaluate the potential role of endoscopic esophageal surveillance for esophageal second primary tumors (ESPTs) in Western patients with head and neck squamous cell carcinoma (HNSCC).

METHODS: Outcomes were cumulative incidence and risk factors for ESPTs and its effect on overall survival.

RESULTS: A total of 47 ESPTs were observed in 1,708 patients with HNSCC, with 10-year cumulative incidence (95% confidence interval) of 2.9% (2.1-3.7). Alcohol and HNSCC location were significant predictors for ESPTs. ESPTs significantly increased the risk of dying (adjusted hazard ratio 3.36, 95% confidence interval 2.16-5.22).

DISCUSSION: Endoscopic esophageal surveillance of Western patients with HNSCC with high risk of ESPTs seems justified.

Original language	English
Pages (from-to)	794-797
Number of pages	4
Journal	American Journal of Gastroenterology
Volume	117
Issue number	5
Early online date	25 Feb 2022
DOIs	https://doi.org/10.14309/ajg.0000000000001711
Publication status	Published - 1 May 2022

Keywords

Carcinoma, Squamous Cell/epidemiology
Cohort Studies
Esophageal Neoplasms/pathology
Head and Neck Neoplasms/complications
Humans
Incidence
Neoplasms, Multiple Primary/pathology
Neoplasms, Second Primary/epidemiology
Risk Factors
Squamous Cell Carcinoma of Head and Neck/epidemiology

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title = "Esophageal second primary tumors in patients with head and neck squamous cell carcinoma: incidence, risk factors and overall survival",

abstract = "INTRODUCTION: The aim of this registry-based cohort study was to evaluate the potential role of endoscopic esophageal surveillance for esophageal second primary tumors (ESPTs) in Western patients with head and neck squamous cell carcinoma (HNSCC).METHODS: Outcomes were cumulative incidence and risk factors for ESPTs and its effect on overall survival.RESULTS: A total of 47 ESPTs were observed in 1,708 patients with HNSCC, with 10-year cumulative incidence (95% confidence interval) of 2.9% (2.1-3.7). Alcohol and HNSCC location were significant predictors for ESPTs. ESPTs significantly increased the risk of dying (adjusted hazard ratio 3.36, 95% confidence interval 2.16-5.22).DISCUSSION: Endoscopic esophageal surveillance of Western patients with HNSCC with high risk of ESPTs seems justified.",

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author = "Anouk Overwater and Kuna Rueb and Elias, {Sjoerd G} and {de Bree}, Remco and Weusten, {Bas L A M}",

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doi = "10.14309/ajg.0000000000001711",

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TY - JOUR

T1 - Esophageal second primary tumors in patients with head and neck squamous cell carcinoma

T2 - incidence, risk factors and overall survival

AU - Overwater, Anouk

AU - Rueb, Kuna

AU - Elias, Sjoerd G

AU - de Bree, Remco

AU - Weusten, Bas L A M

PY - 2022/5/1

Y1 - 2022/5/1

N2 - INTRODUCTION: The aim of this registry-based cohort study was to evaluate the potential role of endoscopic esophageal surveillance for esophageal second primary tumors (ESPTs) in Western patients with head and neck squamous cell carcinoma (HNSCC).METHODS: Outcomes were cumulative incidence and risk factors for ESPTs and its effect on overall survival.RESULTS: A total of 47 ESPTs were observed in 1,708 patients with HNSCC, with 10-year cumulative incidence (95% confidence interval) of 2.9% (2.1-3.7). Alcohol and HNSCC location were significant predictors for ESPTs. ESPTs significantly increased the risk of dying (adjusted hazard ratio 3.36, 95% confidence interval 2.16-5.22).DISCUSSION: Endoscopic esophageal surveillance of Western patients with HNSCC with high risk of ESPTs seems justified.

AB - INTRODUCTION: The aim of this registry-based cohort study was to evaluate the potential role of endoscopic esophageal surveillance for esophageal second primary tumors (ESPTs) in Western patients with head and neck squamous cell carcinoma (HNSCC).METHODS: Outcomes were cumulative incidence and risk factors for ESPTs and its effect on overall survival.RESULTS: A total of 47 ESPTs were observed in 1,708 patients with HNSCC, with 10-year cumulative incidence (95% confidence interval) of 2.9% (2.1-3.7). Alcohol and HNSCC location were significant predictors for ESPTs. ESPTs significantly increased the risk of dying (adjusted hazard ratio 3.36, 95% confidence interval 2.16-5.22).DISCUSSION: Endoscopic esophageal surveillance of Western patients with HNSCC with high risk of ESPTs seems justified.

KW - Carcinoma, Squamous Cell/epidemiology

KW - Cohort Studies

KW - Esophageal Neoplasms/pathology

KW - Head and Neck Neoplasms/complications

KW - Humans

KW - Incidence

KW - Neoplasms, Multiple Primary/pathology

KW - Neoplasms, Second Primary/epidemiology

KW - Risk Factors

KW - Squamous Cell Carcinoma of Head and Neck/epidemiology

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DO - 10.14309/ajg.0000000000001711

M3 - Article

C2 - 35213400

SN - 0002-9270

VL - 117

SP - 794

EP - 797

JO - American Journal of Gastroenterology

JF - American Journal of Gastroenterology

IS - 5

ER -

Esophageal second primary tumors in patients with head and neck squamous cell carcinoma: incidence, risk factors and overall survival

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