Erratum: Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade (Cancer Cell (2018) 33(5) (922–936.e10), (S1535610818301740), (10.1016/j.ccell.2018.04.003))

Cecile A.W. Geuijen, Camilla De Nardis, David Maussang, Eric Rovers, Tristan Gallenne, Linda J.A. Hendriks, Therese Visser, Roy Nijhuis, Ton Logtenberg, John de Kruif, Piet Gros, Mark Throsby*

*Corresponding author for this work

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Abstract

(Cancer Cell 33, 922–936.e1–e10; May 14, 2018) We reported the generation of a bispecific antibody against HER2 and HER3 using an unbiased combinatorial screening approach. During the preparation of the manuscript, we unintentionally introduced an error in Figure 2C and its legend, where a treatment arm was incorrectly labeled as “MM-121” and should have been “PG3178.” We have now corrected Figure 2 and its corresponding legend, shown here. In the Results section, when describing the results presented in Figure 2C, “PG3178” was again incorrectly referenced as “MM-121”. The corrected text reads as follows: “As previously reported for the tyrosine kinase inhibitor lapatinib (Wilson et al., 2012), the inhibitory activity of HER3 mAb PG3178 (2 nM, Figure 2C) was reduced in a dose-dependent manner as the HRG concentration increased beyond its EC90 value for growth stimulation (0.11 nM)”. The other references to the analog of MM-121 in the manuscript are correct. We apologize for any confusions this error may have caused.[Figure

Original languageEnglish
Pages (from-to)1163-1164
Number of pages2
JournalCancer Cell
Volume39
Issue number8
DOIs
Publication statusPublished - 9 Aug 2021
Externally publishedYes

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