Epidemiology of leukaemia and lymphoma in children and young adults from the north of England, 1990-2002

Richard G Feltbower; Richard J Q McNally; Sally E Kinsey; Ian J Lewis; Susan V Picton; Stephen J Proctor; Michael Richards; Geoff Shenton; Rod Skinner; Daniel P Stark; Josef Vormoor; Kevin P Windebank; Patricia A McKinney

doi:10.1016/j.ejca.2008.09.020

Epidemiology of leukaemia and lymphoma in children and young adults from the north of England, 1990-2002

Richard G Feltbower, Richard J Q McNally, Sally E Kinsey, Ian J Lewis, Susan V Picton, Stephen J Proctor, Michael Richards, Geoff Shenton, Rod Skinner, Daniel P Stark, Josef Vormoor, Kevin P Windebank, Patricia A McKinney

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

AIM: We aimed to describe and contrast the epidemiology of haematological malignancies among 0-14 and 15-24-year-olds in northern England from 1990 to 2002 and compare clinical trial entry by age group.

PATIENTS AND METHODS: Incidence rates were examined by age, sex and period of diagnosis and differences were tested using Poisson regression. Differences and trends in survival were assessed using Cox regression.

RESULTS: 1680 subjects were included comprising 948 leukaemias and 732 lymphomas. Incidence rates for acute lymphoblastic leukaemia were significantly higher for 0-14 compared to 15-24-year-olds, whilst Hodgkin lymphoma showed the reverse. No significant changes in incidence were observed. 60% of leukaemia patients aged 15-24 years entered trials compared to 92% of 0-14-year-olds. Survival rates were significantly lower and improved less markedly over time for 15-24 compared to 0-14-year-olds, particularly for leukaemia.

CONCLUSIONS: Trial accrual rates need to be improved amongst 15-24-year-olds and a more structured follow-up approach adopted for this unique population.

Original language	English
Pages (from-to)	420-7
Number of pages	8
Journal	European Journal of Cancer
Volume	45
Issue number	3
DOIs	https://doi.org/10.1016/j.ejca.2008.09.020
Publication status	Published - Feb 2009
Externally published	Yes

Keywords

Adolescent
Age Distribution
Antineoplastic Combined Chemotherapy Protocols/therapeutic use
Child
Child, Preschool
England/epidemiology
Female
Humans
Incidence
Infant
Infant, Newborn
Leukemia/epidemiology
Lymphoma/epidemiology
Male
Quality of Life/psychology
Registries
Sex Distribution
Survival Rate/trends
Young Adult

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10.1016/j.ejca.2008.09.020

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Feltbower, R. G., McNally, R. J. Q., Kinsey, S. E., Lewis, I. J., Picton, S. V., Proctor, S. J., Richards, M., Shenton, G., Skinner, R., Stark, D. P., Vormoor, J., Windebank, K. P., & McKinney, P. A. (2009). Epidemiology of leukaemia and lymphoma in children and young adults from the north of England, 1990-2002. European Journal of Cancer, 45(3), 420-7. https://doi.org/10.1016/j.ejca.2008.09.020

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title = "Epidemiology of leukaemia and lymphoma in children and young adults from the north of England, 1990-2002",

abstract = "AIM: We aimed to describe and contrast the epidemiology of haematological malignancies among 0-14 and 15-24-year-olds in northern England from 1990 to 2002 and compare clinical trial entry by age group.PATIENTS AND METHODS: Incidence rates were examined by age, sex and period of diagnosis and differences were tested using Poisson regression. Differences and trends in survival were assessed using Cox regression.RESULTS: 1680 subjects were included comprising 948 leukaemias and 732 lymphomas. Incidence rates for acute lymphoblastic leukaemia were significantly higher for 0-14 compared to 15-24-year-olds, whilst Hodgkin lymphoma showed the reverse. No significant changes in incidence were observed. 60% of leukaemia patients aged 15-24 years entered trials compared to 92% of 0-14-year-olds. Survival rates were significantly lower and improved less markedly over time for 15-24 compared to 0-14-year-olds, particularly for leukaemia.CONCLUSIONS: Trial accrual rates need to be improved amongst 15-24-year-olds and a more structured follow-up approach adopted for this unique population.",

keywords = "Adolescent, Age Distribution, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Child, Child, Preschool, England/epidemiology, Female, Humans, Incidence, Infant, Infant, Newborn, Leukemia/epidemiology, Lymphoma/epidemiology, Male, Quality of Life/psychology, Registries, Sex Distribution, Survival Rate/trends, Young Adult",

author = "Feltbower, {Richard G} and McNally, {Richard J Q} and Kinsey, {Sally E} and Lewis, {Ian J} and Picton, {Susan V} and Proctor, {Stephen J} and Michael Richards and Geoff Shenton and Rod Skinner and Stark, {Daniel P} and Josef Vormoor and Windebank, {Kevin P} and McKinney, {Patricia A}",

year = "2009",

month = feb,

doi = "10.1016/j.ejca.2008.09.020",

language = "English",

volume = "45",

pages = "420--7",

journal = "European Journal of Cancer",

issn = "0959-8049",

publisher = "Elsevier Limited",

number = "3",

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Feltbower, RG, McNally, RJQ, Kinsey, SE, Lewis, IJ, Picton, SV, Proctor, SJ, Richards, M, Shenton, G, Skinner, R, Stark, DP, Vormoor, J, Windebank, KP & McKinney, PA 2009, 'Epidemiology of leukaemia and lymphoma in children and young adults from the north of England, 1990-2002', European Journal of Cancer, vol. 45, no. 3, pp. 420-7. https://doi.org/10.1016/j.ejca.2008.09.020

TY - JOUR

T1 - Epidemiology of leukaemia and lymphoma in children and young adults from the north of England, 1990-2002

AU - Feltbower, Richard G

AU - McNally, Richard J Q

AU - Kinsey, Sally E

AU - Lewis, Ian J

AU - Picton, Susan V

AU - Proctor, Stephen J

AU - Richards, Michael

AU - Shenton, Geoff

AU - Skinner, Rod

AU - Stark, Daniel P

AU - Vormoor, Josef

AU - Windebank, Kevin P

AU - McKinney, Patricia A

PY - 2009/2

Y1 - 2009/2

N2 - AIM: We aimed to describe and contrast the epidemiology of haematological malignancies among 0-14 and 15-24-year-olds in northern England from 1990 to 2002 and compare clinical trial entry by age group.PATIENTS AND METHODS: Incidence rates were examined by age, sex and period of diagnosis and differences were tested using Poisson regression. Differences and trends in survival were assessed using Cox regression.RESULTS: 1680 subjects were included comprising 948 leukaemias and 732 lymphomas. Incidence rates for acute lymphoblastic leukaemia were significantly higher for 0-14 compared to 15-24-year-olds, whilst Hodgkin lymphoma showed the reverse. No significant changes in incidence were observed. 60% of leukaemia patients aged 15-24 years entered trials compared to 92% of 0-14-year-olds. Survival rates were significantly lower and improved less markedly over time for 15-24 compared to 0-14-year-olds, particularly for leukaemia.CONCLUSIONS: Trial accrual rates need to be improved amongst 15-24-year-olds and a more structured follow-up approach adopted for this unique population.

AB - AIM: We aimed to describe and contrast the epidemiology of haematological malignancies among 0-14 and 15-24-year-olds in northern England from 1990 to 2002 and compare clinical trial entry by age group.PATIENTS AND METHODS: Incidence rates were examined by age, sex and period of diagnosis and differences were tested using Poisson regression. Differences and trends in survival were assessed using Cox regression.RESULTS: 1680 subjects were included comprising 948 leukaemias and 732 lymphomas. Incidence rates for acute lymphoblastic leukaemia were significantly higher for 0-14 compared to 15-24-year-olds, whilst Hodgkin lymphoma showed the reverse. No significant changes in incidence were observed. 60% of leukaemia patients aged 15-24 years entered trials compared to 92% of 0-14-year-olds. Survival rates were significantly lower and improved less markedly over time for 15-24 compared to 0-14-year-olds, particularly for leukaemia.CONCLUSIONS: Trial accrual rates need to be improved amongst 15-24-year-olds and a more structured follow-up approach adopted for this unique population.

KW - Adolescent

KW - Age Distribution

KW - Antineoplastic Combined Chemotherapy Protocols/therapeutic use

KW - Child

KW - Child, Preschool

KW - England/epidemiology

KW - Female

KW - Humans

KW - Incidence

KW - Infant

KW - Infant, Newborn

KW - Leukemia/epidemiology

KW - Lymphoma/epidemiology

KW - Male

KW - Quality of Life/psychology

KW - Registries

KW - Sex Distribution

KW - Survival Rate/trends

KW - Young Adult

U2 - 10.1016/j.ejca.2008.09.020

DO - 10.1016/j.ejca.2008.09.020

M3 - Article

C2 - 19004628

SN - 0959-8049

VL - 45

SP - 420

EP - 427

JO - European Journal of Cancer

JF - European Journal of Cancer

IS - 3

ER -

Epidemiology of leukaemia and lymphoma in children and young adults from the north of England, 1990-2002

Abstract

Keywords

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