TY - JOUR
T1 - Epidemiology and outcome of Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-KP) infections in cardiac surgery patients
T2 - a brief narrative review
AU - Del Puente, Filippo
AU - Giacobbe, Daniele R.
AU - Salsano, Antonio
AU - Maraolo, Alberto E.
AU - Ong, David S.Y.
AU - Yusuf, Erlangga
AU - Tutino, Stefania
AU - Marchese, Anna
AU - Santini, Francesco
AU - Viscoli, Claudio
PY - 2019/11/17
Y1 - 2019/11/17
N2 - Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-KP) is a difficult-to-treat pathogen due to its multidrug-resistant phenotype. Cardiac surgery patients are at increased risk of developing KPC-KP infections compared to other populations, with previous KPC-KP colonization being a critical factor in influencing the risk of subsequent infection. Two different pieces of information are essential to comprehensively assess the local characteristics of KPC-KP colonization in cardiac surgery patients: (i) the local prevalence of colonization; (ii) the timing of colonization. Treatment of KPC-KP infections in cardiac surgery patients is a complex task, but more effective treatment options have recently become available. Nonetheless, implementation and full adherence to infection-control measures remain of pivotal importance for reducing the burden of KPC-KP infections in this peculiar population. The aim of this narrative review is to summarize the available literature on the epidemiology and outcome of KPC-KP infections in cardiac surgery patients.
AB - Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-KP) is a difficult-to-treat pathogen due to its multidrug-resistant phenotype. Cardiac surgery patients are at increased risk of developing KPC-KP infections compared to other populations, with previous KPC-KP colonization being a critical factor in influencing the risk of subsequent infection. Two different pieces of information are essential to comprehensively assess the local characteristics of KPC-KP colonization in cardiac surgery patients: (i) the local prevalence of colonization; (ii) the timing of colonization. Treatment of KPC-KP infections in cardiac surgery patients is a complex task, but more effective treatment options have recently become available. Nonetheless, implementation and full adherence to infection-control measures remain of pivotal importance for reducing the burden of KPC-KP infections in this peculiar population. The aim of this narrative review is to summarize the available literature on the epidemiology and outcome of KPC-KP infections in cardiac surgery patients.
KW - Bacterial Proteins/metabolism
KW - Cardiac Surgical Procedures/adverse effects
KW - Humans
KW - Klebsiella Infections/epidemiology
KW - Klebsiella pneumoniae/pathogenicity
KW - Risk Factors
KW - beta-Lactamases/metabolism
UR - http://www.scopus.com/inward/record.url?scp=85075078258&partnerID=8YFLogxK
U2 - 10.1080/1120009X.2019.1685794
DO - 10.1080/1120009X.2019.1685794
M3 - Review article
C2 - 31701842
AN - SCOPUS:85075078258
SN - 1120-009X
VL - 31
SP - 359
EP - 366
JO - Journal of Chemotherapy
JF - Journal of Chemotherapy
IS - 7-8
ER -