Epidemiology and molecular typing of multidrug-resistant bacteria in tertiary hospitals and nursing homes in Flanders, Belgium

Stefanie van Kleef-van Koeveringe; Veerle Matheeussen; Annette Schuermans; Sien De Koster; Natascha Perales Selva; Hilde Jansens; Dieter De Coninck; Katrien De Bruyne; Klaas Mensaert; Marjolein Kluytmans-van den Bergh; Jan Kluytmans; Herman Goossens; Wouter Dhaeze; Isabel Leroux-Roels

doi:10.1007/s10096-023-04699-2

Epidemiology and molecular typing of multidrug-resistant bacteria in tertiary hospitals and nursing homes in Flanders, Belgium

Stefanie van Kleef-van Koeveringe^*, Veerle Matheeussen, Annette Schuermans, Sien De Koster, Natascha Perales Selva, Hilde Jansens, Dieter De Coninck, Katrien De Bruyne, Klaas Mensaert, Marjolein Kluytmans-van den Bergh, Jan Kluytmans, Herman Goossens, Wouter Dhaeze, Isabel Leroux-Roels

^*Corresponding author for this work

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Abstract

This study aimed to map MDRO carriage and potential transmission within and between three Flemish tertiary care hospitals and their neighbouring nursing homes. A cross-sectional MDRO prevalence survey was organized between October 2017 and February 2019. Perianal swabs were cultured for detection of MDRO. Determination of clonal relatedness based on wgMLST allelic profiles was performed. The prevalence of MDRO in Belgian hospitals and NHs is on the rise, compared to previous studies, and transmission in and between institutions is observed. These results re-emphasize the need for a healthcare network-wide infection prevention strategy in which WGS of MDRO strains can be supportive.

Original language	English
Pages (from-to)	187-194
Number of pages	8
Journal	European Journal of Clinical Microbiology and Infectious Diseases
Volume	43
Issue number	1
Early online date	16 Nov 2023
DOIs	https://doi.org/10.1007/s10096-023-04699-2
Publication status	Published - Jan 2024

Keywords

MDRO
Molecular typing
Screening
Transmission
wgMLST
Whole-genome sequencing

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van Kleef-van Koeveringe, S., Matheeussen, V., Schuermans, A., De Koster, S., Perales Selva, N., Jansens, H., De Coninck, D., De Bruyne, K., Mensaert, K., Kluytmans-van den Bergh, M., Kluytmans, J., Goossens, H., Dhaeze, W., & Leroux-Roels, I. (2024). Epidemiology and molecular typing of multidrug-resistant bacteria in tertiary hospitals and nursing homes in Flanders, Belgium. European Journal of Clinical Microbiology and Infectious Diseases, 43(1), 187-194. https://doi.org/10.1007/s10096-023-04699-2

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abstract = "This study aimed to map MDRO carriage and potential transmission within and between three Flemish tertiary care hospitals and their neighbouring nursing homes. A cross-sectional MDRO prevalence survey was organized between October 2017 and February 2019. Perianal swabs were cultured for detection of MDRO. Determination of clonal relatedness based on wgMLST allelic profiles was performed. The prevalence of MDRO in Belgian hospitals and NHs is on the rise, compared to previous studies, and transmission in and between institutions is observed. These results re-emphasize the need for a healthcare network-wide infection prevention strategy in which WGS of MDRO strains can be supportive.",

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doi = "10.1007/s10096-023-04699-2",

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van Kleef-van Koeveringe, S, Matheeussen, V, Schuermans, A, De Koster, S, Perales Selva, N, Jansens, H, De Coninck, D, De Bruyne, K, Mensaert, K, Kluytmans-van den Bergh, M, Kluytmans, J, Goossens, H, Dhaeze, W & Leroux-Roels, I 2024, 'Epidemiology and molecular typing of multidrug-resistant bacteria in tertiary hospitals and nursing homes in Flanders, Belgium', European Journal of Clinical Microbiology and Infectious Diseases, vol. 43, no. 1, pp. 187-194. https://doi.org/10.1007/s10096-023-04699-2

Epidemiology and molecular typing of multidrug-resistant bacteria in tertiary hospitals and nursing homes in Flanders, Belgium. / van Kleef-van Koeveringe, Stefanie; Matheeussen, Veerle; Schuermans, Annette et al.
In: European Journal of Clinical Microbiology and Infectious Diseases, Vol. 43, No. 1, 01.2024, p. 187-194.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - De Coninck, Dieter

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AU - Mensaert, Klaas

AU - Kluytmans-van den Bergh, Marjolein

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AU - Leroux-Roels, Isabel

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AB - This study aimed to map MDRO carriage and potential transmission within and between three Flemish tertiary care hospitals and their neighbouring nursing homes. A cross-sectional MDRO prevalence survey was organized between October 2017 and February 2019. Perianal swabs were cultured for detection of MDRO. Determination of clonal relatedness based on wgMLST allelic profiles was performed. The prevalence of MDRO in Belgian hospitals and NHs is on the rise, compared to previous studies, and transmission in and between institutions is observed. These results re-emphasize the need for a healthcare network-wide infection prevention strategy in which WGS of MDRO strains can be supportive.

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van Kleef-van Koeveringe S, Matheeussen V, Schuermans A, De Koster S, Perales Selva N, Jansens H et al. Epidemiology and molecular typing of multidrug-resistant bacteria in tertiary hospitals and nursing homes in Flanders, Belgium. European Journal of Clinical Microbiology and Infectious Diseases. 2024 Jan;43(1):187-194. Epub 2023 Nov 16. doi: 10.1007/s10096-023-04699-2

Epidemiology and molecular typing of multidrug-resistant bacteria in tertiary hospitals and nursing homes in Flanders, Belgium

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Keywords

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