Enzymatic method for inactivation of aminoglycosides during measurement of postantibiotic effect

J. G. Den Hollander; J. W. Mouton; I. A.J.M. Bakker-Woudenberg; F. P. Vleggaar; M. P.J. Van Goor; H. A. Verbrugh

Enzymatic method for inactivation of aminoglycosides during measurement of postantibiotic effect

J. G. Den Hollander^*
, J. W. Mouton
, I. A.J.M. Bakker-Woudenberg
, F. P. Vleggaar
, M. P.J. Van Goor
, H. A. Verbrugh

^*Corresponding author for this work

Cancer

Research output: Contribution to journal › Article › Academic › peer-review

9 Citations (Scopus)

Abstract

To determine the postantibiotic effect of aminoglycosides, two methods are currently being used to remove the test drug: repeated washing and dilution. An enzymatic inactivation method of removing gentamicin and tobramycin was developed and compared with the dilution method. This enzymatic method provides a rapid and simple alternative method of removing aminoglycosides which results in reliable postantibiotic-effect values.

Original language	English
Pages (from-to)	488-490
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	40
Issue number	2
Publication status	Published - 1 Feb 1996

Cite this

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title = "Enzymatic method for inactivation of aminoglycosides during measurement of postantibiotic effect",

abstract = "To determine the postantibiotic effect of aminoglycosides, two methods are currently being used to remove the test drug: repeated washing and dilution. An enzymatic inactivation method of removing gentamicin and tobramycin was developed and compared with the dilution method. This enzymatic method provides a rapid and simple alternative method of removing aminoglycosides which results in reliable postantibiotic-effect values.",

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AU - Den Hollander, J. G.

AU - Mouton, J. W.

AU - Bakker-Woudenberg, I. A.J.M.

AU - Vleggaar, F. P.

AU - Van Goor, M. P.J.

AU - Verbrugh, H. A.

PY - 1996/2/1

Y1 - 1996/2/1

N2 - To determine the postantibiotic effect of aminoglycosides, two methods are currently being used to remove the test drug: repeated washing and dilution. An enzymatic inactivation method of removing gentamicin and tobramycin was developed and compared with the dilution method. This enzymatic method provides a rapid and simple alternative method of removing aminoglycosides which results in reliable postantibiotic-effect values.

AB - To determine the postantibiotic effect of aminoglycosides, two methods are currently being used to remove the test drug: repeated washing and dilution. An enzymatic inactivation method of removing gentamicin and tobramycin was developed and compared with the dilution method. This enzymatic method provides a rapid and simple alternative method of removing aminoglycosides which results in reliable postantibiotic-effect values.

UR - https://www.scopus.com/pages/publications/0030053632

M3 - Article

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AN - SCOPUS:0030053632

SN - 0066-4804

VL - 40

SP - 488

EP - 490

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 2

ER -

Enzymatic method for inactivation of aminoglycosides during measurement of postantibiotic effect

Abstract

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