Enzymatic method for inactivation of aminoglycosides during measurement of postantibiotic effect

J. G. Den Hollander; J. W. Mouton; I. A.J.M. Bakker-Woudenberg; F. P. Vleggaar; M. P.J. Van Goor; H. A. Verbrugh

Enzymatic method for inactivation of aminoglycosides during measurement of postantibiotic effect

J. G. Den Hollander^*, J. W. Mouton, I. A.J.M. Bakker-Woudenberg, F. P. Vleggaar, M. P.J. Van Goor, H. A. Verbrugh

^*Corresponding author for this work

Cancer

Research output: Contribution to journal › Article › Academic › peer-review

9 Citations (Scopus)

Abstract

To determine the postantibiotic effect of aminoglycosides, two methods are currently being used to remove the test drug: repeated washing and dilution. An enzymatic inactivation method of removing gentamicin and tobramycin was developed and compared with the dilution method. This enzymatic method provides a rapid and simple alternative method of removing aminoglycosides which results in reliable postantibiotic-effect values.

Original language	English
Pages (from-to)	488-490
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	40
Issue number	2
Publication status	Published - 1 Feb 1996

Cite this

@article{ce4a1c242e784c57996f3db9c95b9a67,

title = "Enzymatic method for inactivation of aminoglycosides during measurement of postantibiotic effect",

abstract = "To determine the postantibiotic effect of aminoglycosides, two methods are currently being used to remove the test drug: repeated washing and dilution. An enzymatic inactivation method of removing gentamicin and tobramycin was developed and compared with the dilution method. This enzymatic method provides a rapid and simple alternative method of removing aminoglycosides which results in reliable postantibiotic-effect values.",

author = "{Den Hollander}, {J. G.} and Mouton, {J. W.} and Bakker-Woudenberg, {I. A.J.M.} and Vleggaar, {F. P.} and {Van Goor}, {M. P.J.} and Verbrugh, {H. A.}",

year = "1996",

month = feb,

day = "1",

language = "English",

volume = "40",

pages = "488--490",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "2",

}

TY - JOUR

T1 - Enzymatic method for inactivation of aminoglycosides during measurement of postantibiotic effect

AU - Den Hollander, J. G.

AU - Mouton, J. W.

AU - Bakker-Woudenberg, I. A.J.M.

AU - Vleggaar, F. P.

AU - Van Goor, M. P.J.

AU - Verbrugh, H. A.

PY - 1996/2/1

Y1 - 1996/2/1

N2 - To determine the postantibiotic effect of aminoglycosides, two methods are currently being used to remove the test drug: repeated washing and dilution. An enzymatic inactivation method of removing gentamicin and tobramycin was developed and compared with the dilution method. This enzymatic method provides a rapid and simple alternative method of removing aminoglycosides which results in reliable postantibiotic-effect values.

AB - To determine the postantibiotic effect of aminoglycosides, two methods are currently being used to remove the test drug: repeated washing and dilution. An enzymatic inactivation method of removing gentamicin and tobramycin was developed and compared with the dilution method. This enzymatic method provides a rapid and simple alternative method of removing aminoglycosides which results in reliable postantibiotic-effect values.

UR - http://www.scopus.com/inward/record.url?scp=0030053632&partnerID=8YFLogxK

M3 - Article

C2 - 8834906

AN - SCOPUS:0030053632

SN - 0066-4804

VL - 40

SP - 488

EP - 490

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 2

ER -

Enzymatic method for inactivation of aminoglycosides during measurement of postantibiotic effect

Abstract

Other files and links

Fingerprint

Cite this