Enterococcus faecalis Pneumonia Complicating Topical Antimicrobial Prophylaxis

Marc J.m. Bonten; Frank H. Van Tiel; Siebe Van Der Geest; Ellen E Stobberingh; Carlo A. Gaillard

doi:10.1056/NEJM199301213280311

Enterococcus faecalis Pneumonia Complicating Topical Antimicrobial Prophylaxis

Marc J.m. Bonten
, Frank H. Van Tiel
, Siebe Van Der Geest
, Ellen E Stobberingh
, Carlo A. Gaillard

Research output: Contribution to journal › Letter › Academic › peer-review

51 Citations (Scopus)

Abstract

To the Editor: Selective decontamination of the digestive tract is widely used to prevent nosocomial pneumonia in patients receiving mechanical ventilation, although its benefits are unproved¹. Objections to this procedure concern the possible selection of microorganisms resistant to the antibiotics used, rather than adverse effects². We report eight cases of pneumonia or bacteremia caused by Enterococcus faecalis, as a possible side effect of the prophylactic use of nonabsorbable antimicrobial agents. Sixty-one patients who were receiving mechanical ventilation in the intensive care unit were given topical antimicrobial prophylaxis for the oropharynx and stomach. Tobramycin (40 mg in a 5-ml… © 1993, Massachusetts Medical Society. All rights reserved.

Original language	English
Pages (from-to)	209-210
Number of pages	2
Journal	New England Journal of Medicine
Volume	328
Issue number	3
DOIs	https://doi.org/10.1056/NEJM199301213280311
Publication status	Published - 21 Jan 1993
Externally published	Yes

Keywords

Anti-Bacterial Agents Bacteremia Cross Infection Drug Therapy, Combination Enterococcus faecalis Gram-Positive Bacterial Infections Humans Pneumonia

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10.1056/NEJM199301213280311

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8417392

Cite this

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title = "Enterococcus faecalis Pneumonia Complicating Topical Antimicrobial Prophylaxis",

abstract = "To the Editor: Selective decontamination of the digestive tract is widely used to prevent nosocomial pneumonia in patients receiving mechanical ventilation, although its benefits are unproved1. Objections to this procedure concern the possible selection of microorganisms resistant to the antibiotics used, rather than adverse effects2. We report eight cases of pneumonia or bacteremia caused by Enterococcus faecalis, as a possible side effect of the prophylactic use of nonabsorbable antimicrobial agents. Sixty-one patients who were receiving mechanical ventilation in the intensive care unit were given topical antimicrobial prophylaxis for the oropharynx and stomach. Tobramycin (40 mg in a 5-ml… {\textcopyright} 1993, Massachusetts Medical Society. All rights reserved.",

keywords = "Anti-Bacterial Agents Bacteremia Cross Infection Drug Therapy, Combination Enterococcus faecalis Gram-Positive Bacterial Infections Humans Pneumonia",

author = "Bonten, \{Marc J.m.\} and \{Van Tiel\}, \{Frank H.\} and \{Van Der Geest\}, Siebe and Stobberingh, \{Ellen E\} and Gaillard, \{Carlo A.\}",

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TY - JOUR

T1 - Enterococcus faecalis Pneumonia Complicating Topical Antimicrobial Prophylaxis

AU - Bonten, Marc J.m.

AU - Van Tiel, Frank H.

AU - Van Der Geest, Siebe

AU - Stobberingh, Ellen E

AU - Gaillard, Carlo A.

N1 - M1 - 3

PY - 1993/1/21

Y1 - 1993/1/21

N2 - To the Editor: Selective decontamination of the digestive tract is widely used to prevent nosocomial pneumonia in patients receiving mechanical ventilation, although its benefits are unproved1. Objections to this procedure concern the possible selection of microorganisms resistant to the antibiotics used, rather than adverse effects2. We report eight cases of pneumonia or bacteremia caused by Enterococcus faecalis, as a possible side effect of the prophylactic use of nonabsorbable antimicrobial agents. Sixty-one patients who were receiving mechanical ventilation in the intensive care unit were given topical antimicrobial prophylaxis for the oropharynx and stomach. Tobramycin (40 mg in a 5-ml… © 1993, Massachusetts Medical Society. All rights reserved.

AB - To the Editor: Selective decontamination of the digestive tract is widely used to prevent nosocomial pneumonia in patients receiving mechanical ventilation, although its benefits are unproved1. Objections to this procedure concern the possible selection of microorganisms resistant to the antibiotics used, rather than adverse effects2. We report eight cases of pneumonia or bacteremia caused by Enterococcus faecalis, as a possible side effect of the prophylactic use of nonabsorbable antimicrobial agents. Sixty-one patients who were receiving mechanical ventilation in the intensive care unit were given topical antimicrobial prophylaxis for the oropharynx and stomach. Tobramycin (40 mg in a 5-ml… © 1993, Massachusetts Medical Society. All rights reserved.

KW - Anti-Bacterial Agents Bacteremia Cross Infection Drug Therapy, Combination Enterococcus faecalis Gram-Positive Bacterial Infections Humans Pneumonia

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SN - 0028-4793

VL - 328

SP - 209

EP - 210

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 3

ER -

Enterococcus faecalis Pneumonia Complicating Topical Antimicrobial Prophylaxis

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Keywords

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