Enhanced susceptibility to subcutaneous abscess formation and persistent infection around catheters is associated with sustained interleukin-1beta levels

J J Boelens; S A Zaat; J L Murk; J J Weening; T van Der Poll; J Dankert

Enhanced susceptibility to subcutaneous abscess formation and persistent infection around catheters is associated with sustained interleukin-1beta levels

J J Boelens
, S A Zaat
, J L Murk
, J J Weening
, T van Der Poll
, J Dankert

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

A persistent Staphylococcus epidermidis infection in mice around a subcutaneous polyvinylpyrrolidone-grafted silicon elastomer catheter (SEpvp) but not around a conventional silicon elastomer catheter was observed. With SEpvp pericatheter tissue, protracted and exaggerated interleukin-1beta (IL-1beta) production was found. Apparently, sustained levels of IL-1beta are associated with enhanced susceptibility to biomaterial-associated S. epidermidis infection.

Original language	English
Pages (from-to)	1692-5
Number of pages	4
Journal	Infection and Immunity
Volume	68
Issue number	3
Publication status	Published - 2000

Keywords

Abscess
Animals
Biocompatible Materials
Catheters, Indwelling
Disease Susceptibility
Female
Interleukin-1
Mice
Mice, Inbred C57BL
Staphylococcal Infections
Staphylococcus epidermidis

Cite this

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title = "Enhanced susceptibility to subcutaneous abscess formation and persistent infection around catheters is associated with sustained interleukin-1beta levels",

abstract = "A persistent Staphylococcus epidermidis infection in mice around a subcutaneous polyvinylpyrrolidone-grafted silicon elastomer catheter (SEpvp) but not around a conventional silicon elastomer catheter was observed. With SEpvp pericatheter tissue, protracted and exaggerated interleukin-1beta (IL-1beta) production was found. Apparently, sustained levels of IL-1beta are associated with enhanced susceptibility to biomaterial-associated S. epidermidis infection.",

keywords = "Abscess, Animals, Biocompatible Materials, Catheters, Indwelling, Disease Susceptibility, Female, Interleukin-1, Mice, Mice, Inbred C57BL, Staphylococcal Infections, Staphylococcus epidermidis",

author = "Boelens, \{J J\} and Zaat, \{S A\} and Murk, \{J L\} and Weening, \{J J\} and \{van Der Poll\}, T and J Dankert",

year = "2000",

language = "English",

volume = "68",

pages = "1692--5",

journal = "Infection and Immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

number = "3",

}

TY - JOUR

T1 - Enhanced susceptibility to subcutaneous abscess formation and persistent infection around catheters is associated with sustained interleukin-1beta levels

AU - Boelens, J J

AU - Zaat, S A

AU - Murk, J L

AU - Weening, J J

AU - van Der Poll, T

AU - Dankert, J

PY - 2000

Y1 - 2000

N2 - A persistent Staphylococcus epidermidis infection in mice around a subcutaneous polyvinylpyrrolidone-grafted silicon elastomer catheter (SEpvp) but not around a conventional silicon elastomer catheter was observed. With SEpvp pericatheter tissue, protracted and exaggerated interleukin-1beta (IL-1beta) production was found. Apparently, sustained levels of IL-1beta are associated with enhanced susceptibility to biomaterial-associated S. epidermidis infection.

AB - A persistent Staphylococcus epidermidis infection in mice around a subcutaneous polyvinylpyrrolidone-grafted silicon elastomer catheter (SEpvp) but not around a conventional silicon elastomer catheter was observed. With SEpvp pericatheter tissue, protracted and exaggerated interleukin-1beta (IL-1beta) production was found. Apparently, sustained levels of IL-1beta are associated with enhanced susceptibility to biomaterial-associated S. epidermidis infection.

KW - Abscess

KW - Animals

KW - Biocompatible Materials

KW - Catheters, Indwelling

KW - Disease Susceptibility

KW - Female

KW - Interleukin-1

KW - Mice

KW - Mice, Inbred C57BL

KW - Staphylococcal Infections

KW - Staphylococcus epidermidis

M3 - Article

C2 - 10678990

SN - 0019-9567

VL - 68

SP - 1692

EP - 1695

JO - Infection and Immunity

JF - Infection and Immunity

IS - 3

ER -

Enhanced susceptibility to subcutaneous abscess formation and persistent infection around catheters is associated with sustained interleukin-1beta levels

Abstract

Keywords

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