Enhanced susceptibility to subcutaneous abscess formation and persistent infection around catheters is associated with sustained interleukin-1 beta levels

JJ Boelens; SAJ Zaat; JL Murk; JJ Weening; T van der Poll; J Dankert

Enhanced susceptibility to subcutaneous abscess formation and persistent infection around catheters is associated with sustained interleukin-1 beta levels

JJ Boelens^*
, SAJ Zaat
, JL Murk
, JJ Weening
, T van der Poll
, J Dankert

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

A persistent Staphylococcus epidermidis infection in mice around a subcutaneous polyvinypyrrolidone-grafted silicon elastomer catheter (SEpvp) but not around a conventional silicon elastomer catheter was observed. With SEpvp pericatheter tissue, protracted and exaggerated interleukin-1 beta (IL-1 beta) production was found. Apparently, sustained levels of IL-1 beta are associated with enhanced susceptibility to biomaterial-associated S. epidermidis infection.

Original language	English
Pages (from-to)	1692-1695
Number of pages	4
Journal	Infection and Immunity
Volume	68
Issue number	3
Publication status	Published - Mar 2000

Keywords

TUMOR-NECROSIS-FACTOR
COMPLICATIONS
MODEL

Cite this

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title = "Enhanced susceptibility to subcutaneous abscess formation and persistent infection around catheters is associated with sustained interleukin-1 beta levels",

abstract = "A persistent Staphylococcus epidermidis infection in mice around a subcutaneous polyvinypyrrolidone-grafted silicon elastomer catheter (SEpvp) but not around a conventional silicon elastomer catheter was observed. With SEpvp pericatheter tissue, protracted and exaggerated interleukin-1 beta (IL-1 beta) production was found. Apparently, sustained levels of IL-1 beta are associated with enhanced susceptibility to biomaterial-associated S. epidermidis infection.",

keywords = "TUMOR-NECROSIS-FACTOR, COMPLICATIONS, MODEL",

author = "JJ Boelens and SAJ Zaat and JL Murk and JJ Weening and \{van der Poll\}, T and J Dankert",

year = "2000",

month = mar,

language = "English",

volume = "68",

pages = "1692--1695",

journal = "Infection and Immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

number = "3",

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TY - JOUR

T1 - Enhanced susceptibility to subcutaneous abscess formation and persistent infection around catheters is associated with sustained interleukin-1 beta levels

AU - Boelens, JJ

AU - Zaat, SAJ

AU - Murk, JL

AU - Weening, JJ

AU - van der Poll, T

AU - Dankert, J

PY - 2000/3

Y1 - 2000/3

N2 - A persistent Staphylococcus epidermidis infection in mice around a subcutaneous polyvinypyrrolidone-grafted silicon elastomer catheter (SEpvp) but not around a conventional silicon elastomer catheter was observed. With SEpvp pericatheter tissue, protracted and exaggerated interleukin-1 beta (IL-1 beta) production was found. Apparently, sustained levels of IL-1 beta are associated with enhanced susceptibility to biomaterial-associated S. epidermidis infection.

AB - A persistent Staphylococcus epidermidis infection in mice around a subcutaneous polyvinypyrrolidone-grafted silicon elastomer catheter (SEpvp) but not around a conventional silicon elastomer catheter was observed. With SEpvp pericatheter tissue, protracted and exaggerated interleukin-1 beta (IL-1 beta) production was found. Apparently, sustained levels of IL-1 beta are associated with enhanced susceptibility to biomaterial-associated S. epidermidis infection.

KW - TUMOR-NECROSIS-FACTOR

KW - COMPLICATIONS

KW - MODEL

M3 - Article

SN - 0019-9567

VL - 68

SP - 1692

EP - 1695

JO - Infection and Immunity

JF - Infection and Immunity

IS - 3

ER -

Enhanced susceptibility to subcutaneous abscess formation and persistent infection around catheters is associated with sustained interleukin-1 beta levels

Abstract

Keywords

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