Enhanced hepatic clearance of hyposialylated platelets explains thrombocytopenia in GNE-related macrothrombocytopenia

Tessa Noordermeer; Ivar van Asten; Roger E.G. Schutgens; Anke J. Lakerveld; Cornelis A. Koekman; Kay Y. Hage; Silvie A.E. Sebastian; Albert Huisman; Dave J. van den Heuvel; Hans C. Gerritsen; Suzanne J.A. Korporaal; Marc Bierings; Jasper J. van der Smagt; Marielle E. van Gijn; Rolf T. Urbanus

doi:10.1182/bloodadvances.2021006830

Enhanced hepatic clearance of hyposialylated platelets explains thrombocytopenia in GNE-related macrothrombocytopenia

Tessa Noordermeer
, Ivar van Asten
, Roger E.G. Schutgens
, Anke J. Lakerveld
, Cornelis A. Koekman
, Kay Y. Hage
, Silvie A.E. Sebastian
, Albert Huisman
, Dave J. van den Heuvel
, Hans C. Gerritsen
, Suzanne J.A. Korporaal
, Marc Bierings
, Jasper J. van der Smagt
, Marielle E. van Gijn
, Rolf T. Urbanus^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

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Original language	English
Pages (from-to)	3347-3351
Number of pages	5
Journal	Blood Advances
Volume	6
Issue number	11
Early online date	7 Mar 2022
DOIs	https://doi.org/10.1182/bloodadvances.2021006830
Publication status	Published - 14 Jun 2022

Keywords

Anemia
Blood Platelets
Humans
Platelet Count
Thrombocytopenia

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10.1182/bloodadvances.2021006830Licence: CC BY-NC-ND

advancesadv2021006830Final published version, 855 KBLicence: CC BY-NC-ND

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Noordermeer, T., van Asten, I., Schutgens, R. E. G., Lakerveld, A. J., Koekman, C. A., Hage, K. Y., Sebastian, S. A. E., Huisman, A., van den Heuvel, D. J., Gerritsen, H. C., Korporaal, S. J. A., Bierings, M., van der Smagt, J. J., van Gijn, M. E., & Urbanus, R. T. (2022). Enhanced hepatic clearance of hyposialylated platelets explains thrombocytopenia in GNE-related macrothrombocytopenia. Blood Advances, 6(11), 3347-3351. https://doi.org/10.1182/bloodadvances.2021006830

@article{2c0510e6d13445688a40b00151997785,

title = "Enhanced hepatic clearance of hyposialylated platelets explains thrombocytopenia in GNE-related macrothrombocytopenia",

keywords = "Anemia, Blood Platelets, Humans, Platelet Count, Thrombocytopenia",

author = "Tessa Noordermeer and \{van Asten\}, Ivar and Schutgens, \{Roger E.G.\} and Lakerveld, \{Anke J.\} and Koekman, \{Cornelis A.\} and Hage, \{Kay Y.\} and Sebastian, \{Silvie A.E.\} and Albert Huisman and \{van den Heuvel\}, \{Dave J.\} and Gerritsen, \{Hans C.\} and Korporaal, \{Suzanne J.A.\} and Marc Bierings and \{van der Smagt\}, \{Jasper J.\} and \{van Gijn\}, \{Marielle E.\} and Urbanus, \{Rolf T.\}",

note = "Funding Information: Acknowledgments: Funding support for this article was provided by the Netherlands Thrombosis Foundation (2018-03).",

year = "2022",

month = jun,

day = "14",

doi = "10.1182/bloodadvances.2021006830",

language = "English",

volume = "6",

pages = "3347--3351",

journal = "Blood Advances",

issn = "2473-9529",

publisher = "American Society of Hematology",

number = "11",

}

Noordermeer, T, van Asten, I, Schutgens, REG, Lakerveld, AJ, Koekman, CA, Hage, KY, Sebastian, SAE, Huisman, A, van den Heuvel, DJ, Gerritsen, HC, Korporaal, SJA, Bierings, M , van der Smagt, JJ, van Gijn, ME & Urbanus, RT 2022, 'Enhanced hepatic clearance of hyposialylated platelets explains thrombocytopenia in GNE-related macrothrombocytopenia', Blood Advances, vol. 6, no. 11, pp. 3347-3351. https://doi.org/10.1182/bloodadvances.2021006830

TY - JOUR

T1 - Enhanced hepatic clearance of hyposialylated platelets explains thrombocytopenia in GNE-related macrothrombocytopenia

AU - Noordermeer, Tessa

AU - van Asten, Ivar

AU - Schutgens, Roger E.G.

AU - Lakerveld, Anke J.

AU - Koekman, Cornelis A.

AU - Hage, Kay Y.

AU - Sebastian, Silvie A.E.

AU - Huisman, Albert

AU - van den Heuvel, Dave J.

AU - Gerritsen, Hans C.

AU - Korporaal, Suzanne J.A.

AU - Bierings, Marc

AU - van der Smagt, Jasper J.

AU - van Gijn, Marielle E.

AU - Urbanus, Rolf T.

N1 - Funding Information: Acknowledgments: Funding support for this article was provided by the Netherlands Thrombosis Foundation (2018-03).

PY - 2022/6/14

Y1 - 2022/6/14

KW - Anemia

KW - Blood Platelets

KW - Humans

KW - Platelet Count

KW - Thrombocytopenia

UR - https://www.scopus.com/pages/publications/85132316031

U2 - 10.1182/bloodadvances.2021006830

DO - 10.1182/bloodadvances.2021006830

M3 - Comment/Letter to the editor

C2 - 35255501

SN - 2473-9529

VL - 6

SP - 3347

EP - 3351

JO - Blood Advances

JF - Blood Advances

IS - 11

ER -

Enhanced hepatic clearance of hyposialylated platelets explains thrombocytopenia in GNE-related macrothrombocytopenia

Keywords

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