Engineered heart tissue patches: A milestone in cardiac regenerative medicine

Alain van Mil; Jasmijn Janssen; Eva van Rooij

doi:10.1016/j.stem.2025.02.012

Engineered heart tissue patches: A milestone in cardiac regenerative medicine

Alain van Mil, Jasmijn Janssen, Eva van Rooij^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Researchers have demonstrated that a stem cell-derived heart muscle patch can safely remuscularize failing hearts.1 Published in Nature, the study shows successful long-term cardiac integration of a patch in a primate model and a human patient with no adverse effects. This breakthrough marks a major step toward regenerative therapies for advanced heart failure.

Original language	English
Pages (from-to)	505-507
Number of pages	3
Journal	Cell stem cell
Volume	32
Issue number	4
DOIs	https://doi.org/10.1016/j.stem.2025.02.012
Publication status	Published - 3 Apr 2025

Keywords

Animals
Heart Failure/therapy
Heart/physiology
Humans
Myocardium/cytology
Regenerative Medicine/methods
Tissue Engineering/methods

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10.1016/j.stem.2025.02.012

Cite this

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title = "Engineered heart tissue patches: A milestone in cardiac regenerative medicine",

abstract = "Researchers have demonstrated that a stem cell-derived heart muscle patch can safely remuscularize failing hearts.1 Published in Nature, the study shows successful long-term cardiac integration of a patch in a primate model and a human patient with no adverse effects. This breakthrough marks a major step toward regenerative therapies for advanced heart failure.",

keywords = "Animals, Heart Failure/therapy, Heart/physiology, Humans, Myocardium/cytology, Regenerative Medicine/methods, Tissue Engineering/methods",

author = "{van Mil}, Alain and Jasmijn Janssen and {van Rooij}, Eva",

note = "Publisher Copyright: {\textcopyright} 2025 Elsevier Inc.",

year = "2025",

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doi = "10.1016/j.stem.2025.02.012",

language = "English",

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journal = "Cell stem cell",

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AU - van Mil, Alain

AU - Janssen, Jasmijn

AU - van Rooij, Eva

PY - 2025/4/3

Y1 - 2025/4/3

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AB - Researchers have demonstrated that a stem cell-derived heart muscle patch can safely remuscularize failing hearts.1 Published in Nature, the study shows successful long-term cardiac integration of a patch in a primate model and a human patient with no adverse effects. This breakthrough marks a major step toward regenerative therapies for advanced heart failure.

KW - Animals

KW - Heart Failure/therapy

KW - Heart/physiology

KW - Humans

KW - Myocardium/cytology

KW - Regenerative Medicine/methods

KW - Tissue Engineering/methods

U2 - 10.1016/j.stem.2025.02.012

DO - 10.1016/j.stem.2025.02.012

M3 - Article

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SN - 1934-5909

VL - 32

SP - 505

EP - 507

JO - Cell stem cell

JF - Cell stem cell

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ER -

Engineered heart tissue patches: A milestone in cardiac regenerative medicine

Abstract

Keywords

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