Endothelial CD34 is suppressed in human malignancies: Role of angiogenic factors

Sandra M.M. Hellwig; Cora A. Damen; Niek P.H. Van Adrichem; Geert H. Blijham; Gerard Groenewegen; Arjan W. Griffioen

doi:10.1016/S0304-3835(97)00310-8

Endothelial CD34 is suppressed in human malignancies: Role of angiogenic factors

Sandra M.M. Hellwig, Cora A. Damen, Niek P.H. Van Adrichem, Geert H. Blijham, Gerard Groenewegen, Arjan W. Griffioen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

45 Citations (Scopus)

Abstract

We report the suppressed vascular CD34 expression in renal cell carcinoma. This was found by quantitatively analyzing CD34 expression on normal and tumor derived EC by flow cytometry. In vitro studies revealed that culture of umbilical cord or dermis derived microvascular EC with angiogenic factors such as basic fibroblast growth factor (bFGF) and vascular endothelial cell growth factor induced downregulation of CD34. This angiogenesis-induced downregulated expression of CD34 adhesion molecule may contribute to the tumor mediated escape mechanism from immune surveillance. It is concluded that there are quantitative differences in expression of endothelial CD34 in different compartments of the vasculature, that angiogenic factors affect this expression and that subpopulations of EC exist with differences in EAM expression.

Original language	English
Pages (from-to)	203-211
Number of pages	9
Journal	Cancer Letters
Volume	120
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(97)00310-8
Publication status	Published - 9 Dec 1997

Keywords

Adhesion molecules
Angiogenesis
CD34
Endothelium
Tumors

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title = "Endothelial CD34 is suppressed in human malignancies: Role of angiogenic factors",

abstract = "We report the suppressed vascular CD34 expression in renal cell carcinoma. This was found by quantitatively analyzing CD34 expression on normal and tumor derived EC by flow cytometry. In vitro studies revealed that culture of umbilical cord or dermis derived microvascular EC with angiogenic factors such as basic fibroblast growth factor (bFGF) and vascular endothelial cell growth factor induced downregulation of CD34. This angiogenesis-induced downregulated expression of CD34 adhesion molecule may contribute to the tumor mediated escape mechanism from immune surveillance. It is concluded that there are quantitative differences in expression of endothelial CD34 in different compartments of the vasculature, that angiogenic factors affect this expression and that subpopulations of EC exist with differences in EAM expression.",

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T1 - Endothelial CD34 is suppressed in human malignancies

T2 - Role of angiogenic factors

AU - Hellwig, Sandra M.M.

AU - Damen, Cora A.

AU - Van Adrichem, Niek P.H.

AU - Blijham, Geert H.

AU - Groenewegen, Gerard

AU - Griffioen, Arjan W.

PY - 1997/12/9

Y1 - 1997/12/9

N2 - We report the suppressed vascular CD34 expression in renal cell carcinoma. This was found by quantitatively analyzing CD34 expression on normal and tumor derived EC by flow cytometry. In vitro studies revealed that culture of umbilical cord or dermis derived microvascular EC with angiogenic factors such as basic fibroblast growth factor (bFGF) and vascular endothelial cell growth factor induced downregulation of CD34. This angiogenesis-induced downregulated expression of CD34 adhesion molecule may contribute to the tumor mediated escape mechanism from immune surveillance. It is concluded that there are quantitative differences in expression of endothelial CD34 in different compartments of the vasculature, that angiogenic factors affect this expression and that subpopulations of EC exist with differences in EAM expression.

AB - We report the suppressed vascular CD34 expression in renal cell carcinoma. This was found by quantitatively analyzing CD34 expression on normal and tumor derived EC by flow cytometry. In vitro studies revealed that culture of umbilical cord or dermis derived microvascular EC with angiogenic factors such as basic fibroblast growth factor (bFGF) and vascular endothelial cell growth factor induced downregulation of CD34. This angiogenesis-induced downregulated expression of CD34 adhesion molecule may contribute to the tumor mediated escape mechanism from immune surveillance. It is concluded that there are quantitative differences in expression of endothelial CD34 in different compartments of the vasculature, that angiogenic factors affect this expression and that subpopulations of EC exist with differences in EAM expression.

KW - Adhesion molecules

KW - Angiogenesis

KW - CD34

KW - Endothelium

KW - Tumors

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DO - 10.1016/S0304-3835(97)00310-8

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SN - 0304-3835

VL - 120

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JO - Cancer Letters

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Endothelial CD34 is suppressed in human malignancies: Role of angiogenic factors

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