Endorectal Brachytherapy Boost After External Beam Radiation Therapy in Elderly or Medically Inoperable Patients With Rectal Cancer: Primary Outcomes of the Phase 1 HERBERT Study

Eva C. Rijkmans; Annemieke Cats; Remi A. Nout; Desiree van den Bongard; Martijn Ketelaars; Jeroen Buijsen; Tom Rozema; Jan Huib Franssen; Laura A. Velema; Baukelien van Triest; Corrie A M Marijnen

doi:10.1016/j.ijrobp.2017.01.033

Endorectal Brachytherapy Boost After External Beam Radiation Therapy in Elderly or Medically Inoperable Patients With Rectal Cancer: Primary Outcomes of the Phase 1 HERBERT Study

Eva C. Rijkmans^*
, Annemieke Cats
, Remi A. Nout
, Desiree van den Bongard
, Martijn Ketelaars
, Jeroen Buijsen
, Tom Rozema
, Jan Huib Franssen
, Laura A. Velema
, Baukelien van Triest
, Corrie A M Marijnen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Purpose: To evaluate the toxicity and efficacy of the combination of external beam radiation therapy (EBRT) followed by high-dose-rate endorectal brachytherapy (HDREBT) boost in elderly and medically inoperable patients with rectal cancer. Methods and Materials: A phase 1 dose-escalation study was performed. Treatment consisted of EBRT (13 × 3 Gy) followed by 3 weekly brachytherapy applications 6 weeks later. The HDREBT dose started at 5 Gy per fraction, increasing with 1 Gy per fraction if dose-limiting toxicity (DLT, defined as grade ≥3 proctitis

Original language	English
Pages (from-to)	908-917
Number of pages	10
Journal	International Journal of Radiation Oncology Biology Physics
Volume	98
Issue number	4
DOIs	https://doi.org/10.1016/j.ijrobp.2017.01.033
Publication status	Published - Jul 2017

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10.1016/j.ijrobp.2017.01.033

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Rijkmans, E. C., Cats, A., Nout, R. A., van den Bongard, D., Ketelaars, M., Buijsen, J., Rozema, T., Franssen, J. H., Velema, L. A., van Triest, B., & Marijnen, C. A. M. (2017). Endorectal Brachytherapy Boost After External Beam Radiation Therapy in Elderly or Medically Inoperable Patients With Rectal Cancer: Primary Outcomes of the Phase 1 HERBERT Study. International Journal of Radiation Oncology Biology Physics, 98(4), 908-917. https://doi.org/10.1016/j.ijrobp.2017.01.033

@article{89cbc3cf3b04441896af16abe59dc7f1,

title = "Endorectal Brachytherapy Boost After External Beam Radiation Therapy in Elderly or Medically Inoperable Patients With Rectal Cancer: Primary Outcomes of the Phase 1 HERBERT Study",

abstract = "Purpose: To evaluate the toxicity and efficacy of the combination of external beam radiation therapy (EBRT) followed by high-dose-rate endorectal brachytherapy (HDREBT) boost in elderly and medically inoperable patients with rectal cancer. Methods and Materials: A phase 1 dose-escalation study was performed. Treatment consisted of EBRT (13 × 3 Gy) followed by 3 weekly brachytherapy applications 6 weeks later. The HDREBT dose started at 5 Gy per fraction, increasing with 1 Gy per fraction if dose-limiting toxicity (DLT, defined as grade ≥3 proctitis ",

author = "Rijkmans, \{Eva C.\} and Annemieke Cats and Nout, \{Remi A.\} and \{van den Bongard\}, Desiree and Martijn Ketelaars and Jeroen Buijsen and Tom Rozema and Franssen, \{Jan Huib\} and Velema, \{Laura A.\} and \{van Triest\}, Baukelien and Marijnen, \{Corrie A M\}",

year = "2017",

month = jul,

doi = "10.1016/j.ijrobp.2017.01.033",

language = "English",

volume = "98",

pages = "908--917",

journal = "International Journal of Radiation Oncology Biology Physics",

issn = "0360-3016",

publisher = "Elsevier",

number = "4",

}

Rijkmans, EC, Cats, A, Nout, RA, van den Bongard, D, Ketelaars, M, Buijsen, J, Rozema, T, Franssen, JH, Velema, LA, van Triest, B & Marijnen, CAM 2017, 'Endorectal Brachytherapy Boost After External Beam Radiation Therapy in Elderly or Medically Inoperable Patients With Rectal Cancer: Primary Outcomes of the Phase 1 HERBERT Study', International Journal of Radiation Oncology Biology Physics, vol. 98, no. 4, pp. 908-917. https://doi.org/10.1016/j.ijrobp.2017.01.033

Endorectal Brachytherapy Boost After External Beam Radiation Therapy in Elderly or Medically Inoperable Patients With Rectal Cancer: Primary Outcomes of the Phase 1 HERBERT Study. / Rijkmans, Eva C.; Cats, Annemieke; Nout, Remi A. et al.
In: International Journal of Radiation Oncology Biology Physics, Vol. 98, No. 4, 07.2017, p. 908-917.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Endorectal Brachytherapy Boost After External Beam Radiation Therapy in Elderly or Medically Inoperable Patients With Rectal Cancer

T2 - Primary Outcomes of the Phase 1 HERBERT Study

AU - Rijkmans, Eva C.

AU - Cats, Annemieke

AU - Nout, Remi A.

AU - van den Bongard, Desiree

AU - Ketelaars, Martijn

AU - Buijsen, Jeroen

AU - Rozema, Tom

AU - Franssen, Jan Huib

AU - Velema, Laura A.

AU - van Triest, Baukelien

AU - Marijnen, Corrie A M

PY - 2017/7

Y1 - 2017/7

N2 - Purpose: To evaluate the toxicity and efficacy of the combination of external beam radiation therapy (EBRT) followed by high-dose-rate endorectal brachytherapy (HDREBT) boost in elderly and medically inoperable patients with rectal cancer. Methods and Materials: A phase 1 dose-escalation study was performed. Treatment consisted of EBRT (13 × 3 Gy) followed by 3 weekly brachytherapy applications 6 weeks later. The HDREBT dose started at 5 Gy per fraction, increasing with 1 Gy per fraction if dose-limiting toxicity (DLT, defined as grade ≥3 proctitis

AB - Purpose: To evaluate the toxicity and efficacy of the combination of external beam radiation therapy (EBRT) followed by high-dose-rate endorectal brachytherapy (HDREBT) boost in elderly and medically inoperable patients with rectal cancer. Methods and Materials: A phase 1 dose-escalation study was performed. Treatment consisted of EBRT (13 × 3 Gy) followed by 3 weekly brachytherapy applications 6 weeks later. The HDREBT dose started at 5 Gy per fraction, increasing with 1 Gy per fraction if dose-limiting toxicity (DLT, defined as grade ≥3 proctitis

UR - https://www.scopus.com/pages/publications/85016515464

U2 - 10.1016/j.ijrobp.2017.01.033

DO - 10.1016/j.ijrobp.2017.01.033

M3 - Article

C2 - 28366579

AN - SCOPUS:85016515464

SN - 0360-3016

VL - 98

SP - 908

EP - 917

JO - International Journal of Radiation Oncology Biology Physics

JF - International Journal of Radiation Oncology Biology Physics

IS - 4

ER -

Rijkmans EC, Cats A, Nout RA, van den Bongard D, Ketelaars M, Buijsen J et al. Endorectal Brachytherapy Boost After External Beam Radiation Therapy in Elderly or Medically Inoperable Patients With Rectal Cancer: Primary Outcomes of the Phase 1 HERBERT Study. International Journal of Radiation Oncology Biology Physics. 2017 Jul;98(4):908-917. doi: 10.1016/j.ijrobp.2017.01.033

Endorectal Brachytherapy Boost After External Beam Radiation Therapy in Elderly or Medically Inoperable Patients With Rectal Cancer: Primary Outcomes of the Phase 1 HERBERT Study

Abstract

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