TY - JOUR
T1 - Endorectal Brachytherapy Boost After External Beam Radiation Therapy in Elderly or Medically Inoperable Patients With Rectal Cancer
T2 - Primary Outcomes of the Phase 1 HERBERT Study
AU - Rijkmans, Eva C.
AU - Cats, Annemieke
AU - Nout, Remi A.
AU - van den Bongard, Desiree
AU - Ketelaars, Martijn
AU - Buijsen, Jeroen
AU - Rozema, Tom
AU - Franssen, Jan Huib
AU - Velema, Laura A.
AU - van Triest, Baukelien
AU - Marijnen, Corrie A M
PY - 2017/7
Y1 - 2017/7
N2 - Purpose: To evaluate the toxicity and efficacy of the combination of external beam radiation therapy (EBRT) followed by high-dose-rate endorectal brachytherapy (HDREBT) boost in elderly and medically inoperable patients with rectal cancer. Methods and Materials: A phase 1 dose-escalation study was performed. Treatment consisted of EBRT (13 × 3 Gy) followed by 3 weekly brachytherapy applications 6 weeks later. The HDREBT dose started at 5 Gy per fraction, increasing with 1 Gy per fraction if dose-limiting toxicity (DLT, defined as grade ≥3 proctitis
AB - Purpose: To evaluate the toxicity and efficacy of the combination of external beam radiation therapy (EBRT) followed by high-dose-rate endorectal brachytherapy (HDREBT) boost in elderly and medically inoperable patients with rectal cancer. Methods and Materials: A phase 1 dose-escalation study was performed. Treatment consisted of EBRT (13 × 3 Gy) followed by 3 weekly brachytherapy applications 6 weeks later. The HDREBT dose started at 5 Gy per fraction, increasing with 1 Gy per fraction if dose-limiting toxicity (DLT, defined as grade ≥3 proctitis
UR - http://www.scopus.com/inward/record.url?scp=85016515464&partnerID=8YFLogxK
U2 - 10.1016/j.ijrobp.2017.01.033
DO - 10.1016/j.ijrobp.2017.01.033
M3 - Article
C2 - 28366579
AN - SCOPUS:85016515464
SN - 0360-3016
VL - 98
SP - 908
EP - 917
JO - International Journal of Radiation Oncology Biology Physics
JF - International Journal of Radiation Oncology Biology Physics
IS - 4
ER -